Spindle Epithelial Tumour with Thymus-like Differentiation (SETTLE) of the Thyroid Gland with Widespread Metastases in a 13-year-old Girl

Raffel, Andreas; Cupisti, Kenko; Rees, Martin; Jänig, U.; Bernbeck, Benedikt; Jazbec, Janez; Goretzki, P. E.; Göbel, U.

doi:10.1016/s0936-6555(03)00153-5

Cited by 19 publications

(36 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Common metastatic sites in other patients were lungs, bone, kidney and lymph nodes [9,10,[16][17][18][19][20][21]. Raffel et al [9] previously reported a 13-year-old patient with extensive metastatic disease that had spread to lymph nodes, vertebral spine and lungs. Treatment included 7 cycles of chemotherapy (PEI) and additional radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Chemotherapy with the PEI protocol (cisplatin 20 mg/m 2 days 1-5, ifosfamide 1,200 mg/ m 2 days 1-5 and etoposide 75 mg/m 2 days 1-5) was initiated. Treatment was chosen in analogy to therapy protocols for pediatric germ cell malignancies that had previously shown activity in 2 patients with metastatic SETTLE [9]. Restaging after the first cycle of PEI revealed stable disease without any change of tumor volume.…”

Section: Case Reportmentioning

confidence: 99%

See 1 more Smart Citation

Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

Quidde

Alsdorf²,

Amsberg³

et al. 2018

Oncol Res Treat

View full text Add to dashboard Cite

Background: Spindle epithelial tumor with thymus-like differentiation (SETTLE) is a very rare tumor that occurs mainly in pediatric patients and young adults. Only few of these patients develops metastatic disease; therefore, clinical data regarding treatment and outcome of metastatic SETTLE are extremely limited. Several chemotherapy agents have been used in SETTLE but due to the limited number of patients no evidence-based therapy exists. Case Report: We present a case of metastatic SETTLE presenting with high tumor burden and paraneoplastic hypercalcemia. Prolonged disease control with several lines of platinum-based chemotherapy, anti-epidermal growth factor receptor therapy and additional radiotherapy was achieved. Conclusion: Multi-agent chemotherapy is an active treatment in metastatic SETTLE and can induce sustained tumor control.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

Quidde

Alsdorf²,

Amsberg³

et al. 2018

Oncol Res Treat

View full text Add to dashboard Cite

show abstract

“…Adjuvant chemo and radiotherapy were performed in some cases, although the role of the best scheme is not clear. Both chemo and radiotherapy administered after surgery led to complete metastatic disease remission in one case (29).…”

Section: Immunohistochemistrymentioning

confidence: 94%

Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review

Filho

Bordallo

Pessoa

et al. 2010

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

SUMMARYSpindle epithelial tumor with thymus-like element (SETTLE) is a rare malignant neoplasm of the thyroid, occurring predominantly in children, adolescents, and young adults. SETTLE usually presents itself as a thyroid mass, without metastases at diagnosis. It is believed to derive from branchial pouch or thymic remnant tissue showing primitive thymic differentiation. This article reports the clinical, cytological, histological and immunohistochemical features of a SETTLE in a 3-year-old girl. Microscopic exam revealed a nodular, highly cellular neoplasm displayed in the classic biphasic pattern, with mixture of prominent spindle cell component and a minor glandular component lined by mucinous or respiratory-type epithelium. The immunohistochemical study showed strong and diffuse positivity for pan-CK, vimentin and smooth muscle actin. The present case is the first SETTLE case reported in Brazil. To date, the patient described remains without evidence of recurrence or metastasis 5 years after surgery. Arq Bras Endocrinol Metab. 2010;54(7):657-62 SUMÁRIO O tumor epitelial de células fusiformes com elemento thymus-like é uma rara neoplasia maligna da tireoide, ocorrendo predominantemente em crianças, adolescentes e adultos jovens. Habitualmente, esse tumor se apresenta como massa tireoideana, sem metástases ao diagnóstico. Acredita-se derivar de arco branquial ou tecido remanescente tímico, apresentando diferenciação tímica primitiva. Este artigo descreve os aspectos clínicos, citológicos, histológi-cos e imuno-histoquímicos de um caso de SETTLE diagnosticado em uma menina de 3 anos de idade. O aspecto microscópico encontrado no tumor foi de uma lesão nodular, hipercelular, disposta em aspecto bifásico clássico, com componente de células fusiformes, e de tecido glandular acompanhado por epitélio mucinoso e respiratório. O estudo imuno-histoquímico foi positivo para pan-CK, vimentina e actina de músculo liso. Esse caso é o primeiro relato de SETTLE no Brasil. A paciente descrita permanece sem evidência de doença em atividade cinco anos após o tratamento cirúrgico. Arq Bras Endocrinol Metab. 2010;54(7):657-62

show abstract

“…U dosadašnjoj literaturi, svi slučajevi SETTLE tumora (1,3,4,5,6,(8)(9)(10)(11)(12)(13)(14) tretirani su hirurškom intervencijom na tumoru. Adjuvantna hemioterapija i radioterapija primijenjene su u nekim slučajevima iako uloga najboljeg protokola nije jasna.…”

Section: Diskusijaunclassified

“…Adjuvantna hemioterapija i radioterapija primijenjene su u nekim slučajevima iako uloga najboljeg protokola nije jasna. I hemioterapija i radioterapija primijenjene nakon operativnog zahvata dovele su do kompletne remisije metastatske bolesti u jednom slučaju (14).…”

Section: Diskusijaunclassified

Clinical, pathological and therapeutic course of disease in patient with initial diagnosis of metastatic settle tumor: A case report

Cicmil-Sarić¹,

Vučković²,

Basovic-Ristic³

et al. 2015

Medicinski casopis

View full text Add to dashboard Cite

UVODEpitelijalni tumor vretenastih ćelija sa diferencijacijom sličnoj timusu (SETTLE) ekstremno je rijedak tumor štitaste žlijezde za koji se smatra da se razvija iz škržne brazde ili ostataka timusa i pokazuje primitivnu diferencijaciju grudne žlijezde. Formalno su ga okarakterisali Chan i Rosai 1991. godine (1). Pojedinačni izvještaji o ovome tumorskom entitetu prethodno su objavljivani pod različitim oznakama kao što su: tumor vretenastih ćelija štitaste žlijezde sa mukoznom cistom, maligni teratom, tireoidni timom dječije dobi, neuobičajeni tireoidni tumor kod djece (2-6). Promjena je slabo rastumačena a njen potencijal za kasno metastaziranje postaje opštepriznat: iako tumor ima sklonost da razvija kasne hematogene metastaze, rizik od metastaziranja je nejasan jer prikazi slučajeva u novijoj literaturi imaju veoma kratak period praćenja. Prema podacima američkog Nacionalnog centra za biotehnološka istraživanja, naziv SETTLE spomenut je samo 26 puta u engleskoj literaturi do jula 2010. godine. Naveden je 42 puta do kraja juna 2015. u obliku pojedinačnih izvještaja i nepotpunog zbira prethodno objavljenih slučajeva (7-12). Donosimo slučaj bolesnika kod koga za razliku od svih dosad prikazanih slučajeva primarni tumor nikada nije bio pronađen. Zbog toga pacijent nije operisan. Pacijenta smo pratili dok je postojala samo klinička manifestacija oboljenja i od početka liječenja metastatske bolesti do prve ustanovljene RECIST progresije. Smatramo da bi osnivanje međunarodnog tijela za rijetke maligne tumore bilo veoma značajno. PRIKAZ SLUČAJAPrikazujemo slučaj SETTLE tumora kod dvadesettrogodišnjeg muškarca koji je praćen 24 mjeseca: od trenutka postavljanja dijagnoze dok nije ustanovljena progresija bolesti prema RECIST kriterijumima. Ovo je prvi slučaj SETTLE tumora opisan u Crnoj Gori.Polovinom 2011. godine kod bolesnika koji je imao 19 godina na desnoj strani vrata pojavio se bezbolan limfni čvor. Bolesnik nije imao subjektivnih tegoba. Limfni čvor bi postajao vidljiv prilikom okretanja glave na desnu stranu. Javio se stomatologu koji je objasnio da je pojava limfnog čvora posljedica rasta umnjaka i da će iščeznuti nakon što umnjak bude nikao. Izvjesno vrijeme poslije toga limfni čvor nije bio vidljiv. Kada je promjena ponovo postala uočljiva, u martu 2013, pacijent je zatražio

show abstract

Spindle Epithelial Tumour with Thymus-like Differentiation (SETTLE) of the Thyroid Gland with Widespread Metastases in a 13-year-old Girl

Cited by 19 publications

References 16 publications

Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

Treatment of Metastatic Spindle Epithelial Tumor with Thymus-Like Differentiation (SETTLE) - Long-Term Disease Control by Multimodal Therapy

Thyroid spindle epithelial tumor with thymus-like differentiation (SETTLE): case report and review

Clinical, pathological and therapeutic course of disease in patient with initial diagnosis of metastatic settle tumor: A case report

Contact Info

Product

Resources

About