Spindle cell sarcomatoid carcinoma of the trachea: first case report of surgical resection

Abstract

BackgroundPrimary malignant tracheal tumors are rare, accounting for approximately 0.2 % of respiratory tract tumors yearly, with squamous cell carcinomas and adenoid cystic carcinomas accounting for two-thirds of these cases. Sarcomatoid carcinomas are a group of poorly differentiated non-small cell lung carcinomas containing a component of sarcoma or sarcoma-like (spindle and/or giant cell) differentiation, categorized into five morphologic subgroups. Spindle cell sarcomatoid carcinoma is a rare variant of sarcomatoid carcinomas, consisting of only spindle-shaped tumor cells. Only one other case has been reported as a primary tracheal tumor.Case presentationWe present a 75-year-old male, having progressive dyspnea and cough, with a spindle cell sarcomatoid carcinoma tumor visualized on chest computed tomography scan and confirmed with biopsy.ConclusionsDue to its low incidence, knowledge of treatment methods, prognostic factors, and etiology is limited thus approaches to eradication have widely varied. We are reporting the second published case of spindle cell sarcomatoid carcinoma of the trachea and the first reported successful outcome of definitive treatment with tracheal resection.

Spindle cell sarcoma: a SEER population-based analysis

“…As previous studies, SCS occurred at any location of the body involving skin and subcutaneous connective tissue, tongue, sinus, trachea, atrium, vein, bone, etc. 11 , 31 , 32 . For better characterization and further evaluating, we categorized the tumor locations into two main groups according to the distribution of primary tumor site: superficial site (tumor involving skin and subcutaneous soft tissue in head & neck, upper limb & shoulder, lower limb & hip, thorax & breast, abdomen, pelvis, trunk and other) and interior site (included tumor involving bone or viscera of digestive system, respiratory system, reproductive system, locomotors system, urinary system, nervous system, endocrine system, circulatory system).…”

Sarcomatoid carcinoma in the trachea: A case report and literature review

“…Sarcomatoid carcinoma that arises in the trachea is extremely rare. To the best of our knowledge, only two cases have previously been reported in English literature . The clinicopathological features of the previously reported cases and our case are summarized in Table .…”

“…Squamous cell carcinoma and its subtypes have a poor prognosis . Sarcomatoid carcinoma arising in the trachea is extremely infrequent, with only two cases reported to date . As a result, the clinical outcome of tracheal sarcomatoid carcinoma has not been investigated.…”

“…The trachea is infrequently affected by sarcomatoid carcinoma. To date, only two cases of sarcomatoid carcinoma in the trachea have been reported in English literature …”

Tracheolaryngeal Squamous Cell Carcinoma with Extensive Mucosal Spread Without Metastasis in a Female

“…Tracheal tumors have been described in the literature for many years; however, they remain rare [2][3][4][5][6]. Histologically, various subtypes include but are not limited to: squamous cell carcinoma, adenoid cystic carcinoma, mucoepidermoid carcinoma, small cell carcinoma, mucosa-associated lymphoid tissue (MALT) lymphoma, chondrosarcoma, sarcomatoid carcinoma, granular cell tumor, leiomyoma, and glomus tumor [7][8][9][10][11][12][13][14][15][16][17]. Malignant subtypes remain far more common than benign ones [7].…”