Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment

Borota, O. Casar; Scheithauer, Bernd W.; Fougner, Stine Lyngvi; Hald, Jesper; Ramm‐Pettersen, Jon; Bollerslev, Jens

doi:10.5414/npp28091

Cited by 46 publications

(27 citation statements)

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“…The inability to distinguish these lesions from entities such as pituitary adenoma is important because these tumors, unlike pituitary adenomas, tend to be very vascular and are prone to heavy bleeding during surgical resection. 5,52,65 This has often resulted in the need to stabilize the patient, abort the surgery, and consider reoperation at a later date, potentially after embolization of tumor vasculature. 62 If reoperation does not occur, symptomatic recurrence is common.…”

Section: Discussionmentioning

confidence: 99%

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Covington

Chin²,

Osborn³

2011

AJNR Am J Neuroradiol

113

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Section: Discussionmentioning

confidence: 99%

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Covington

Chin²,

Osborn³

2011

AJNR Am J Neuroradiol

113

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“…Indeed, reported nonstandard examples of SCO tend to document features of aggressive behavior rather than any significant departure from its conventional histology [6][7][8]16].…”

Section: Introductionmentioning

confidence: 99%

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

et al. 2011

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Spindle cell oncocytoma (SCO) is a rare, nonadenomatous tumor originating from the anterior pituitary gland. Composed of fusiform, mitochondrion-rich cells sharing several immunophenotypic and ultrastructural properties with folliculo-stellate cells (FSC), SCO has been proposed to represent a neoplastic counterpart of the latter. To date, however, SCO has failed to meet one criterion commonly used in histological-based taxonomy and diagnostics; that of recapitulating any of FSCs' morphologically defined developmental or physiological states. We describe a unique example of SCO wherein a conventional fascicular texture was seen coexisting with and organically merging into follicle-like arrangements. The sellar tumor of 2.7 9 2.6 9 2.5 cm was transphenoidally resected from a 55-year old female. Preoperative magnetic resonance imaging indicated an isointense, contrast enhancing mass with suprasellar extension. Histology showed multiple rudimentary to well-formed, follicle-like cavities on a classical spindle cell background; while all the participating cells exhibited an SCO immunophenotype, including positivity for S100 protein, vimentin, EMA, Bcl-2, and TTF-1, as well as staining with the antimitochondrial antibody 113-1. Conversely no expression of GFAP, follicular-epithelial cytokeratin, carcinoembryonic antigen, or anterior pituitary hormones was detected. Ultrastructurally, tumor cells facing follicular lumina displayed organelles of epithelial specialization, in particular surface microvilli and apical tight junctions. This constellation is felt to be reminiscent of FSCs' metaplastic transition to follicular epithelium, as observed during embryonic development and physiological renewal of the hormone-secreting parenchyma. Such finding is apt to being read as a supporting argument for SCO's descent from the FSC lineage.

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“…Spindle cell oncocytoma of the adenohypophysis is a rare and diagnostically challenging entity with only twenty-four cases reported in the English literature since the first account in 2002 by Roncaroli et al, (Alexandrescu, Brown, Tandon, & Bhattacharjee, 2012;Borges, Lillehei, & KleinschmidtDeMasters, 2011;Borota et al, 2009;Coire, Horvath, Smyth, & Kovacs, 2009;Dahiya et al, 2005;Demssie et al, 2011;Farooq, Bhatt, & Chang, 2008;Fujisawa et al, 2012;Fuller, Scheithauer, Roncaroli, & Wesseling P, 2007;Kloub, Perry, Tu, Lipper, & Lopes, 2005;Matyja et al, 2010;Mlika et al, 2011;Ogiwara, Dubner, Shafizadeh, Raizer, & Chandler, 2011;Romero-Rojas et al, 2011;Roncaroli et al, 2002;Singh et al, 2012;Vajtai, Sahli, & Kappeler, 2006). The classical histologic description of SCO is that of a fascicular neoplasm arising from the adenohypophysis and composed of spindled and epithelial oncocytic cells with immunohistochemical positivity for S100, vimentin, EMA, galectin-3, and antimitochondrial antibodies (Roncaroli et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

Ryu¹,

Hamilton²,

Starreveld³

et al. 2015

IJN

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Spindle cell oncocytoma (SCO) is a rare and recently described neoplasm arising from the pituitary adenohypophysis thought to be derived from the folliculostellate cells. Even though SCO has been classified as a distinct World Health Organization (WHO) grade I tumor, sellar neoplasms with an oncocytic appearance are uncommon and have a wide differential diagnosis that includes primary and metastatic lesions. Herein we describe an oncocytic sellar neoplasm of uncertain histiogenesis arising in a 49-year-old man with BirtHogg-Dubé (BHD) syndrome. This case is also unusual in that individuals with BHD have a propensity to develop oncocytomas, yet to the best of our knowledge this is the first occurrence of a primary oncocytic neoplasm of the sella in BHD syndrome.

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Spindle cell oncocytoma of the adenohypophysis: report of a case with marked cellular atypia and recurrence despite adjuvant treatment

Cited by 46 publications

References 0 publications

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Pituicytoma, Spindle Cell Oncocytoma, and Granular Cell Tumor: Clarification and Meta-Analysis of the World Literature since 1893

Spindle cell oncocytoma of the pituitary gland with follicle-like component: organotypic differentiation to support its origin from folliculo-stellate cells

An Unusual Oncocytic Sellar Neoplasm in a Patient with Birt-Hogg-Dubé Syndrome

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