Spindle Cell Metaplastic Breast Carcinoma with Leiomyoid Differentiation: A Case Report

Conrad, Claudius; Miller, Diane; Kaiser, Christina; Jauch, Karl Walter; Nieß, Hanno; Huss, Ralf

doi:10.1159/000329330

Cited by 6 publications

(5 citation statements)

References 15 publications

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“…Therefore, these 77 articles were excluded. Overall, 65 studies [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ...…”

Section: Resultsmentioning

confidence: 99%

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

et al. 2023

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Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12–118) months, and the median disease-free survival was 56.8 (11–102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02–0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04–2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients’ overall survival.

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Section: Resultsmentioning

confidence: 99%

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

et al. 2023

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“…In the previous reports, 33% of FLMC did not have recognizable squamous or glandular elements [4, 5, 7, 14, 16]. However, most of FLMC tumors exhibit irregular infiltrative margins with broad, finger-like projections of neoplastic cells into the surrounding mammary structures and soft tissue [5, 7].…”

Section: Discussionmentioning

confidence: 99%

Fibromatosis-Like Metaplastic Carcinoma: A Triple-Negative Breast Cancer with Clinically Indolent Behavior

et al. 2022

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Fibromatosis-like metaplastic carcinoma is a special variant of spindle cell carcinoma, a type of metaplastic carcinomas. It has a favorable prognosis, unlike other metaplastic carcinomas, with a particular clinical behavior characterized by frequent local recurrence, the meager potential for axillary lymph nodes, and distant metastases. We presented the case of a 51-year-old female with a large mass on the left breast, which was successfully removed by surgical resection. The pathological diagnosis was fibromatosis-like metaplastic carcinoma with the help of morphology and immunohistochemistry adjustment.

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“…Thus, the standard treatment regimens for ductal carcinoma may not be effective for breast SCC. In a case report, a patient who received radiation therapy and adjuvant chemotherapy developed recurrent disease and eventually died [ 15 ] . Therefore, multidisciplinary treatment is beneficial for patients in complex individual situations [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Primary squamous cell carcinoma of the breast: a case report

Liu,

Chen,

Hou

2024

Discov Onc

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Introduction Squamous cell carcinoma (SCC) of the breast is a rare variant of invasive breast cancer that has been classified as metaplastic carcinoma. When a tumor is composed of spindle cells, diagnosis is challenging. Case report A 42-year-old woman with a large mass in the right breast underwent modified radical mastectomy. A pathological examination revealed a tumor with central necrosis in it. The tumor had a sarcomatoid growth pattern and the cells were spindle-shaped with severe atypicality. Immunohistochemical staining showed that P63, P53, vimentin, and CKpan were positive, whereas estrogen receptor and C-erbB-2 were negative. Ki-67 proliferation index was as high as 90%. Therefore, a diagnosis of SCC of the right breast was made. The patient received eight cycles of postoperative chemotherapy with paclitaxel and carboplatin, followed by seven cycles of radiotherapy. During follow-up, the patient also had a left thyroid tumor, and postoperative pathology suggested microinvasive follicular carcinoma. Since breast surgery, the patient has remained disease-free for more than four years. Conclusion SCC of the breast with spindle cell and sarcomatoid features is rare. The diagnosis of such tumors requires exclusion of tumors with similar histological morphologies.

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Spindle Cell Metaplastic Breast Carcinoma with Leiomyoid Differentiation: A Case Report

Cited by 6 publications

References 15 publications

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

Fibromatosis-Like Metaplastic Carcinoma: A Triple-Negative Breast Cancer with Clinically Indolent Behavior

Primary squamous cell carcinoma of the breast: a case report

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