Spindle Cell Malignant Melanoma Metastatic to the Breast from a Pigmented Lesion on the Back

Artal, Emilio Mayayo; Gómez-Aracil, Virginia; Alvira, Rosa Mayayo; Azúa-Romeo, J.; Arraiza, Alfonso

doi:10.1159/000326390

Cited by 12 publications

(3 citation statements)

References 6 publications

(2 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[ 16 ] Because it has an aggressive biological behavior and presents typically with widespread metastatic disease, despite the availability of surgical therapy, immunotherapy, chemotherapy, or radiotherapy, majority of cases were found at advanced stage and ended up adverse treatment outcome. [ 8 , 10 , 13 , 17 ]…”

Section: Introductionmentioning

confidence: 99%

Desmoplastic melanoma versus spindle cell melanoma

Yibulayin

Shi

et al. 2018

Medicine

View full text Add to dashboard Cite

Desmoplastic melanoma (DM) and spindle cell melanoma (SCM) are 2 rare subtypes of melanoma. This study aims to investigate these 2 melanomas comprehensively by comparison.Cases were identified in the Surveillance, Epidemiology, and End Results (SEER) database (1973–2017).A total of 3657 DM and 4761 SCM cases were identified. DM's female-to-male ratio was 1:2 and SCM's was 0.62:1. The age distribution was similar. Both tumor mostly originated from skin and the eye and orbit was SCM-specific tumor site. Comparing both tumors with DM as reference, significant overall survival (OS) were found depending on sex (women, P < .001), age (age ≤65 years, P < .001), race (white, P = .01), tumor orientation (skin, P < .001), T stage (T3 + T4, P = .001), SEER historic stage (regional tumor, P = .04), and surgery (P = .01). Meanwhile, significant disease specific survival (DSS) differences were found depending on sex (men, P < .001), age (age ≤65 years, P < .001), race (white, P < .001), tumor orientation (skin, P < .001), T early stage (T1 + T2, P = .02), T advanced stage (T3 + T4 stage, P = .001), SEER historic stage (regional tumor, P < .001), and surgery (P < .001). The chance of DSS and OS of SCM were significantly higher comparing to DM for female patients (HR = 1.268, for OS; HR = 1.711, for DSS), patients age ≤65 years (HR = 1.290, for OS; HR = 1.638, for DSS), No-Spanish-Hispanic-Latino patients (HR = 1.098, for OS; HR = 1.426, for DSS), patients with skin tumor (HR = 1.174; for OS; HR = 1.444; for DSS) and patients who received surgery (HR = 1.091; for OS; HR = 1.398, for DSS).DM and SCM mostly occurred in white people’ skin at 60 to 80 years old and eye and orbit was another most affected site for SCM. SCM had slightly higher occurrence in women and the risk of DSS and OS were significantly higher comparing to DM depending on the women, patients age ≤65 years, patients with skin tumor, No-Spanish-Hispanic-Latino patients and patients who received surgery.

show abstract

Section: Introductionmentioning

confidence: 99%

Desmoplastic melanoma versus spindle cell melanoma

Yibulayin

Shi

et al. 2018

Medicine

View full text Add to dashboard Cite

show abstract

“…The other cytologic features of melanoma mentioned in the literature include spindle cell, lymphoma-like, undifferentiated and myxoid. 11 A meta-analysis done by Bakis et al 12 on 1,261 basal cell carcinomas, scrape cytology showed 97% sensitivity. Although the diagnosis is clinical, a preoperative diagnosis may be advantageous to plan the surgery.…”

Section: Discussionmentioning

confidence: 98%

Cytologic Features of Primary Malignant Tumors of Skin and Adnexae

Prayaga¹,

Loya²,

Gottimukkala³

et al. 2008

Acta Cytologica

View full text Add to dashboard Cite

“…Fine-needle aspiration cytology is shown to be an excellent first line diagnostic modality when clinical data are known and if metastatic disease is suspected, the material obtained by fine-needle aspiration provides a definitive diagnosis and prevents open surgical biopsy or mastectomy (8). Following confirmation of histological diagnosis, wide local excision or quadrantectomy is sufficient for surgical treatment in cases with no evidence of multiple metastatic lesions in breast (3,(9)(10)(11). Axillary dissection is possible if a clinically and pathologically positive axillary lymph node is identified (12).…”

Section: Discussionmentioning

confidence: 99%