Spindle Cell Lesions—Neoplastic or Non-Neoplastic?

Lewis, Jr. James S.

doi:10.1007/s12105-008-0055-4

Cited by 56 publications

(65 citation statements)

References 20 publications

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“…Sarcomatoid carcinoma is one specific example. These tumors are a distinct variant of squamous cell carcinoma that frequently originate in the epithelia of the upper aerodigestive tract (12, 20), display spindle cell histology, and typically lose epithelial gene expression consistent with mesenchymal transdifferentiation. Notably, sarcomatoid carcinoma can be biphasic and exhibit discreet regions of squamous and spindle cell histology.…”

Section: Introductionmentioning

confidence: 99%

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

Wang

Zhang

Grabowska

et al. 2011

Molecular Cancer Research

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Trop2, an oncogenic cell-surface protein under investigation as a therapeutic target, is commonly overexpressed in several epithelial tumor types yet its function in tumor biology remains relatively unexplored. To investigate the role of Trop2 in epithelial carcinogenesis, we generated Trop2−/− mice, which are viable and possess a normal lifespan. Contrary to expectations, Trop2 loss fails to suppress keratinocyte transformation. Instead, ras-transformed Trop2−/− keratinocytes preferentially pass through an epithelial to mesenchymal transition (EMT) and form tumors with spindle cell histology. Furthermore, Trop2 loss renders Arf null mice susceptible to the formation of biphasic sarcomatoid carcinomas containing both squamous and spindle cell components upon carcinogen exposure in an otherwise skin-cancer resistant strain (C57Bl/6). Immortalized keratinocytes derived from Trop2−/−Arf−/− mice exhibit enhanced proliferative and migratory capacity as well as increased activation of MAPK and Src prior to transformation. The clinical relevance of these findings was supported by studying the molecular epidemiology of Trop2 in primary head and neck squamous cell carcinomas. This analysis revealed that Trop2 mRNA levels are decreased in a subset of tumors with features of EMT, and total loss of Trop2 protein expression is observed in the spindle cell component of sarcomatoid carcinomas. Therefore, while previous studies have emphasized the potential importance of Trop2 gain-of-function, these results uncover a role for Trop2 loss in tumorigenesis and the mesenchymal transdifferentiation observed in a subset of squamous cell carcinomas.

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Section: Introductionmentioning

confidence: 99%

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

Wang

Zhang

Grabowska

et al. 2011

Molecular Cancer Research

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“…In the present case report, the patient was a chronic alcoholic. Usually, SpCC presents as exophytic, polypoid masses in the larynx [9], rarely as a flat lesion [10]. Similar gross features comprised of a polypoidal lesion on the tongue, which was rapidly grown in a period of one month, was reported in our case.…”

Section: Discussionsupporting

confidence: 77%

ecancermedicalscience

Biradar

Dantkale

Abhange

et al.

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Spindle cell carcinoma (SpCC), a rare, aggressive variant of squamous cell carcinoma (SCC), is characterised by proliferation of epithelial and mesenchymal components. It is important to diagnose this variant of SCC, because of its tendency to recur and early metastasis. It accounts for 1% of all tumours in the oral cavity. In this paper, we have reported a case of SpCC of the tongue in a 65-year-old male who presented with a polypoidal growth over the lateral border of his tongue with a short history of one month. Immunohistochemical expression of cytokeratin was strongly positive in the epithelial component and focally in the spindle cell component. The spindle cell component showed a strong positivity for vimentin.

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“…Almost 100% of the cases show positivity for vimentin and about a third of them for smooth muscle actin [11].…”

Section: Discussionmentioning

confidence: 99%

“…But no clear guideline is available in literature to support one treatment modality over the other. Sarcomatoid carcinoma is considered as a more aggressive tumor, with a tendency to recur and metastasize early when compared to squamous cell carcinoma within the head and neck region [11] [12].…”

Section: Discussionmentioning

confidence: 99%

Spindle Cell Carcinoma of the Maxilla: A Case Report of Rare Entity

Junaid¹,

Kazi²,

Qadeer³

2017

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Spindle cell carcinoma also known as sarcomatoid carcinoma is a rare highly aggressive tumor which is histologically different from squamous cell ca and mesenchymal cancers. Only hands full of cases have been reported in literature since 1957 and hence no proper treatment protocol has been devised yet. We present such a case of thirty-four-year-old female who presented with spindle cell carcinoma of the maxilla at our department and was treated with extensive surgery followed by chemotherapy and radiation therapy. Spindle cell carcinoma is generally associated with poor prognosis and hence literature supports use of post operative Chemo and Radiotherapy for better result and decrease chance of local recurrence.

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Spindle Cell Lesions—Neoplastic or Non-Neoplastic?

Cited by 56 publications

References 20 publications

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

Loss of Trop2 Promotes Carcinogenesis and Features of Epithelial to Mesenchymal Transition in Squamous Cell Carcinoma

ecancermedicalscience

Spindle Cell Carcinoma of the Maxilla: A Case Report of Rare Entity

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