BackgroundSpindle cell hemangioma (SCH), a non-neoplastic reactive vascular lesion, rarely locates in bones. We herein report a successful case of intralesional curettage for an infant with SCH of fibula.Case presentationA 11-month-old male patient was admitted to our center with a painless mass in right proximal calf. Preoperative digital radiograph demonstrated a massive vascular lesion with an irregular bone destruction of proximal fibula. The lesion was removed via the intralesional curettage approach and pathologically diagnosed as SCH. After the surgery, the patient gained bone structure recovery of right proximal fibula. Two years after the surgery, he experienced no local recurrence.ConclusionFor the management of SCH of fibula with partial bone destruction, we suggest early-stage intralesional curettage as its safety and effectiveness.