Spindle cell angiosarcoma almost exclusively made up of spindle cells

Abstract

with AI, neoplastic cells express CD30 antigen. Although the specific pathogenesis of this association remains to be elucidated and several complex factors appear to be involved, some hypotheses have already been proposed, including: secretion of several growth factors by tumor cells; diminished expression of filaggrin; abnormal vitamin A metabolism; impaired dermal lipogenesis [1,[7][8][9]. In conclusion, AI related to primary cutaneous CD30 + LPDs can represent a paraneoplastic syndrome that generally mirrors the course of the underlying cutaneous lymphoid proliferation. However, in this clinical setting is essential to rule out an ichthyosiform MF.