Spinal tumors in children

Joaquim, Andrei Fernandes; Ghizoni, Enrico; Valadares, Marcelo Gomes Cordeiro; Appenzeller, Simone; Aguiar, Simone dos Santos; Tedeschi, Hélder

doi:10.1590/1806-9282.63.05.459

Cited by 9 publications

(9 citation statements)

References 36 publications

(68 reference statements)

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“…Although the radiological examination is the main initial modality in intramedullary spinal cord mass cases, the role of histopathologic examination is mandatory to give a final confirmation of the mass features and type, then determines the final treatment. Remember that the spinal mass is often difficult to distinguish from radiological examination alone [4]. As in this patient, we found the cystic mass mimicking cavernoma on MRI and intraoperative findings, but the histological examination shows unspecified old hematoma.…”

Section: Discussionmentioning

confidence: 51%

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Intramedullary Spinal Cystic Lesions Mimicking Cavernoma with Spontaneous Myelum Hemorrhage in Children: A Case Report

Jani

Parenrengi

Suryaningtyas

2021

Open Access Maced J Med Sci

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Background: Intramedullary spinal masses is a rare yet devastating and challenging. One of the biggest difficulty is to reveal the mass type and feature, thus determine the definitive treatment. Despite its difficulties, many controversies persist regarding diagnosis and management. Case Presentation: We report a case of 6 years old female came with gradual right limb weakness for 1 week before admission. It preceded by neck stiffness and for 2 weeks ago. Radiological examination revealed intradural intramedullary mass suggesting a cavernoma at VC1-C2 and VTh12-L1 level. The histopathological results shows unspecified hematoma. Conclusions: Intramedullary tumors in pediatric population is rare and can mimic any other mass lesion. MRI is the mainstay diagnostic tool of this patient. Complete surgical resection is the main goal of treatment, but the histopathologic features is the most important predictor of the functional outcome.

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Section: Discussionmentioning

confidence: 51%

“…One of the biggest challenges in spinal cord masses is the sensitivity of radiological imaging in diagnosing tumors in children depends on tumor size and histology. Hence, the histological examination is a must to confirm tumor type and guide treatment in this case [4].…”

Section: Introductionmentioning

confidence: 99%

Intramedullary Spinal Cystic Lesions Mimicking Cavernoma with Spontaneous Myelum Hemorrhage in Children: A Case Report

Jani

Parenrengi

Suryaningtyas

2021

Open Access Maced J Med Sci

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“…The spinal cord compression is a rare but extremely serious condition in medical practice, requires an urgent approach and could be the result of an unknown malignant disease 3,5,14 . This clinical presentation occurs in 3-5% of children with cancer, and solid tumors represent the most frequent cause of SCC in this group 3,4,6,15 .…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Compression as Clinical Presentation of Malignant Hematopoietic Diseases in Pediatric Patients

Deu

Bertone

Felice

et al. 2022

MRAJ

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Spinal cord compression (SCC) is an unusual manifestation of leukemias and lymphomas in children and defines an oncological emergency frequently unsuspected, being a cause of severe sequelae. Our aim was to analyze the characteristics of patients who presented signs or symptoms of spinal cord compression in early phases of malignant hematopoietic diseases. From November-1988 to July-2022, 3878 patients with leukemia and lymphoma were diagnosed. Of them, 36 children (0.92%) presented spinal cord compression signs/symptoms in early phases of their diagnosis: Acute Lymphoblastic Leukemia (n=18), Acute Myeloblastic Leukemia and Myeloid Sarcoma (n=7), Non-Hodgkin Lymphomas (n=9) and Hodgkin Lymphoma (n=2). Clinical characteristics, images and hematological findings, treatment strategies, results and sequelae were analyzed. Sex distribution was 3.5/1 (M/F) and the media age at diagnosis was 10 (range: 4.9-16.9) years. The most common symptoms were back pain (34/36), functional impotence (27/36) and sphincter compromise (10/36). The media time from symptom onset to diagnosis was 47,5 (range: 0-300) days. Magnetic resonance imaging was performed on 33 (92%) patients and showed epidural mass (n=16) or vertebral collapse (n=17) in all of them. Two patients received initial radiotherapy and 11 decompressive surgeries for the management of the urgency spinal cord compression. Bone marrow aspiration was the diagnostic procedure in 69% of cases. All patients received chemotherapy and 94% achieved complete remission. Severe sequelae were observed in 10 patients (paraplegia with neurogenic bladder and kyphoscoliosis). Leukemia and lymphoma should be considered as a differential diagnosis when spinal cord compression is suspected, and magnetic resonance imaging is the mandatory study to confirm this diagnosis as a matter of urgency. Bone marrow involvement was evident due to hematological alterations in 95% of cases allowing to guide the diagnosis and initiate treatment early to reduce sequelae.

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“…The intraspinal occupying-lesions comprising tumoral and non-tumoral lesions are relatively rare in children [1][2][3][4], but can lead to serious neurological impairments if left untreated. The majority of the lesions are neoplastic lesions with the incidence less than 3 per 1000,000 persons per year, accounting for only 5% of pediatric central nervous system (CNS) tumors [5].…”

Section: Introductionmentioning

confidence: 99%

“…When symptoms of spinal cord compression occur in patients, a series of sophisticated imaging tools such as magnetic resonance (MR) and computed tomography (CT) could assist the early detection of intraspinal tumors [7]. However, the clinical presentation of intraspinal space-occupying lesions in children is insidious and lacks speci c symptoms [1,2]. Therefore, the actual diagnosis is usually delayed by months or more, which markedly affects the prognosis for the children [6].…”

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confidence: 99%

Intraspinal Space-Occupying Lesions in Children: Clinical Features, Neuroimaging and Surgical Outcomes of 27 Cases

Chang

Jiang

Wang

et al. 2021

Preprint

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Background: Pediatric intraspinal space-occupying lesions are relatively uncommon. However, these lesions can result in neurological disabilities due to misdiagnosis and delayed treatment. The main goal of the present study is to evaluate the clinical and radiological features and treatment options of pediatric intraspinal space-occupying lesions in order to improve the clinical recognition and management. Methods: Clinical data of 27 children with intraspinal space-occupying lesions who underwent surgery treatment in a tertiary-care hospital between 2010 and 2018 were retrospectively reviewed and analyzed. Results: Of these 27 patients, 14 (51.85%) were girls and 13 (48.15%) were boys. The most common age group affected was 10~14 years (62.96%, 9 girls and 8 boys in this age group). The mean age was 10.11 years old. Pain and weakness were the most common clinical symptoms. Preoperative magnetic resonance imaging (MRI) identified intramedullary (10 cases, 37.04%), intradural extramedullary (10 cases, 37.04%) and extradural (7 cases, 25.92%) lesions, respectively. The majority of the lesions were intraspinal tumors (23 cases, 85.19%). The histological diagnosis of tumors included embryonic residual tumors (6 cases, 22.22%), ependymoma (5 cases, 18.52%), primitive neuroectodermal tumors (PNET) (3 cases, 11.11%), schwannomas (2 cases, 7.4%), ganglioneuroma (1 case, 3.7%), Ewing’s sarc (1 case, 3.7%), B-cell non Hodgkin lymphoma (1 case, 3.7%), Hodgkin lymphoma (1 case, 3.7%), chondrosarcoma (1 case, 3.7%), ganglioglioma (1 case, 3.7%), and glioma (1 case, 3.7%). Conclusions: The incidence of pediatric intraspinal space-occupying lesions is low, and the clinical manifestation is lack of specificity. The prognosis for children with malignant tumors is poor and surgical resection is still the primary treatment option.

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Spinal tumors in children

Abstract: SummaryStudy conducted by Discipline

Cited by 9 publications

References 36 publications

Intramedullary Spinal Cystic Lesions Mimicking Cavernoma with Spontaneous Myelum Hemorrhage in Children: A Case Report

Intramedullary Spinal Cystic Lesions Mimicking Cavernoma with Spontaneous Myelum Hemorrhage in Children: A Case Report

Spinal Cord Compression as Clinical Presentation of Malignant Hematopoietic Diseases in Pediatric Patients

Intraspinal Space-Occupying Lesions in Children: Clinical Features, Neuroimaging and Surgical Outcomes of 27 Cases

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