Spinal tuberculosis

Abstract

Tuberculosis (TB) remains endemic in many parts of the developing world and is increasingly seen in the developed world due to migration. A total of 1.3 million people die annually from the disease. Spinal TB is the most common musculoskeletal manifestation, affecting about 1 to 2% of all cases of TB. The coexistence of HIV, which is endemic in some regions, adds to the burden and the complexity of management. This review discusses the epidemiology, clinical presentation, diagnosis, impact of HIV and both the medical and surgical options in the management of spinal TB. Cite this article: Bone Joint J 2018;100-B:425-31.

Diagnostic value of recombinant heparin-binding hemagglutinin adhesin protein in spinal tuberculosis

“…Bacteriological examination is an important method for the diagnosis of spinal tuberculosis, but its culture technology is still lagging behind, the positive rate is low, the current laboratory pathogen detection and identification methods are far from meeting the needs of clinical diagnosis [8]. Lesion biopsy usually has a certain disadvantage and risk factor, and the positive rate is not satisfactory [3,8]. Therefore, the identification of a more reliable diagnostic method for spinal tuberculosis will achieve practical value.…”

“…The pathopoiesis of spinal tuberculosis involves the spread of mycobacterium tuberculosis via blood or lymphatic channels; and then, the secretion of bacterial protein results in allergic disease [3]. Tuberculosis antibody expression levels in serum correlate with the growth and metabolic activity of Mycobacterium tuberculosis in the body.…”

“…Nearly 20 percent of these patients developed extrapulmonary tuberculosis, and 1% to 5% of these patients had spinal tuberculosis [2]. Spinal tuberculosis is a common form of joint tuberculosis and encompasses about 50% of cases of bone tuberculosis, and 1% to 3% of all cases of tuberculosis [3].…”

“…However, irreversible neurological deficits often occur in the later stages of the disease, so early diagnosis is critical [4]. The detection rates of traditional tuberculosis detection methods (such as tuberculin test, smear staining microscopy, Mycobacterium tuberculosis culture, and molecular biology method) for spinal tuberculosis are significantly lower than those for detecting pulmonary tuberculosis [3]. Therefore, it is especially necessary to explore new auxiliary examination methods for spinal tuberculosis.…”

Perfil epidemiológico da tuberculose óssea no Brasil, 2001-2017

“…A TB óssea (TBO) acomete mais comumente a coluna vertebral, a articulação coxofemoral e o joelho, embora possa ocorrer em vários outros locais 5,6 . A TB espinhal (TBE), ou mal de Pott, corresponde a 1 a 2% dos casos de TB extrapulmonar (TBEx) 7,8 , sendo afetados mais comumente os segmentos torácico baixo e lombar 9 .…”