Spinal Seeding of a Pilocytic Astrocytoma in an Adult, Initially Diagnosed 18 Years Previously

Crabtree, Kelli L.; Arnold, Paul M.

doi:10.1159/000315320

Cited by 14 publications

(11 citation statements)

References 59 publications

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“…Several cases of PA dissemination have been reported after surgical intervention [17], [22]. This is less likely the case in our patient, since LD was already visible on the initial MRI examination, before any surgical manipulation of the tumor.…”

Section: Discussion and Review Of Literaturementioning

confidence: 58%

“…PMA is more aggressive than the classic PA and classified as WHO grade II [1]. Previous reports have shown a strong association between PMA and LD [22], [30], [31]. In addition, other reports indicate an association between PMA and intratumoral hemorrhage [7], [32], (25%) in PMA compared with PA (8%) [33], [34].…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

“…Mazloom et al., in a retrospective review of 58 patients with PA with LD, reported that the 5-year survival rate approached 55%. Few cases, however, have shown longer survival [17], [22], that may reach 20 years [22]. Several factors including the extent of the surgical resection, adjuvant radiotherapy, and chemotherapy, the age of the patient and location of the primary tumor play a significant role in patient outcome.…”

Section: Discussion and Review Of Literaturementioning

confidence: 99%

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Suprasellar pilocytic astrocytoma in an adult with hemorrhage and leptomeningeal dissemination: case report and review of literature

Soliman

Budai

Mundada

et al. 2016

Radiology Case Reports

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Pilocytic astrocytoma (PA) is a low-grade tumor. It has an excellent prognosis after total resection. Leptomeningeal dissemination and hemorrhage are very rare to be associated with PA and lead to unfavorable prognosis. A 35-year-old man was diagnosed with a hemorrhagic suprasellar PA in 2006. Subsequent examination in 2007 revealed another large subdural hemorrhagic lesion in the sacral region, which proved to be PA by histopathologic assessment. Other leptomeningeal foci were discovered mainly at the craniocervical junction. The patient underwent subtotal resection and received chemotherapy with disease control for 7 years. Progression of the disseminated disease has recently occurred; however, the patient is still alive with stable disease after radiotherapy. The radiological features, management, and relevant literature are also presented. Our report heightens the awareness of PA in the adult population and the importance of close surveillance for the leptomeningeal spread, especially for sellar region tumors.

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Section: Discussion and Review Of Literaturementioning

confidence: 58%

Section: Discussion and Review Of Literaturementioning

confidence: 99%

Section: Discussion and Review Of Literaturementioning

confidence: 99%

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Suprasellar pilocytic astrocytoma in an adult with hemorrhage and leptomeningeal dissemination: case report and review of literature

Soliman

Budai

Mundada

et al. 2016

Radiology Case Reports

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“…11 The metastatic potential of pilocytic astrocytomas 5,9,18 and oligoastrocytomas 16,33 has also been described. Metastasis by a low-grade, nonpilocytic astrocytoma has been rarely reported in the literature, although the first report was in 1930.…”

Section: Discussionmentioning

confidence: 99%

Endoscopic diagnosis of an MRI-occult, low-grade glioma with ependymal dissemination

Margetis¹,

Rajappa²,

Cope

et al. 2015

PED

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A 21-year-old man presented with triventricular hydrocephalus due to a tectal mass. He underwent an endoscopic third ventriculostomy, and multiple nodules were identified at the floor of the third ventricle intraoperatively. Surgical pathology of one of these lesions demonstrated that the tissue represented a low-grade astrocytoma. The case highlights the existing potential of neuroendoscopy to reveal neuroimaging-occult lesions, in spite of the significant advances of MRI. Furthermore, the combination of the age of the patient, the nonenhancing MRI appearance, and the multifocality of the lesions constitutes a rare and interesting neoplastic presentation within the brain. The constellation of findings likely represents dissemination of a low-grade tectal glioma via the CSF compartment.

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“…Pilocytic astrocytoma is a WHO grade I tumor with a good prognosis after complete excision. Although occasional leptomeningeal dissemination has been reported in the past, drop metastasis in a pilocytic astrocytoma is very rare [12]. The CNS neoplasms, which frequently show drop metastases, are primitive neuroectodermal tumors, medulloblastomas, ependymomas and high-grade gliomas.…”

Section: Discussionmentioning

confidence: 99%

Dual Gliomas with Syringomyelia in a Child: Case Report and Literature Review

Patibandla

Kumar²,

Bhattacharjee³

et al. 2012

Pediatr Neurosurg

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Background and Importance: The occurrence of multiple tumors of different histopathologies in the central nervous -system is rare. Here, we report a case of a child with dual neuroepithelial tumors of different histological cell types and -review the available literature for analyzing the causal hypo-thesis. Case Report: A 7-year-old girl presented with history of headaches associated with multiple episodes of early morning projectile vomiting and visual blurring. Magnetic resonance imaging (MRI) showed a well-defined lesion in the hypothalamic region. The patient underwent resection of the tumor by the transcallosal transfornicial approach. Histopathology was suggestive of pilocytic astrocytoma. After 3 years, the patient presented with low back pain radiating to the right lower limb followed by sudden onset of weakness in both lower limbs. Recent MRI brain and spine scans showed a small residual lesion at the hypothalamus with D1 to D10 syrinx. A T1 hypointense and T2 hyperintense cystic lesion from D10 to S2 with intensely enhancing solid component at the S1, S2 region was also detected. The patient underwent L4 to S2 laminectomy and the histopathological examin-ation revealed myxopapillary ependymoma. Conclusion: The presence of multiple neuroepithelial tumors of different histopathology in the same patient is extremely rare, and we report one such case of dual gliomas with hypothalamic pilocytic astrocytoma and cauda equina myxopapillary ependymoma in a 10-year-old patient. During the course of development, displacement and dedifferentiation of primitive totipotent neuroepithelial germ cells may be a causal factor for the appearance of the different neuroepithelial tumors in neuraxis concomitantly or subsequently, which might be substantiated by common cytogenetic abnormalities in different neuroepithelial tumor histogenesis.

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Spinal Seeding of a Pilocytic Astrocytoma in an Adult, Initially Diagnosed 18 Years Previously

Cited by 14 publications

References 59 publications

Suprasellar pilocytic astrocytoma in an adult with hemorrhage and leptomeningeal dissemination: case report and review of literature

Suprasellar pilocytic astrocytoma in an adult with hemorrhage and leptomeningeal dissemination: case report and review of literature

Endoscopic diagnosis of an MRI-occult, low-grade glioma with ependymal dissemination

Dual Gliomas with Syringomyelia in a Child: Case Report and Literature Review

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