Spinal schistosomiasis: Cases in Egyptian population

Ashour, Ahmed M; Elserry, Tarek; Nosser, Mohamed S; Fayed, Zeyad Y; Samir, Mohamed W.; Fakher, Alaa; Ashour, Maamoun Mohamad; Salama, Mamdouh M.

doi:10.4103/jcvjs.jcvjs_2_18

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…Without prompt treatment, the prognosis is poor [2 , 9 , 11] . Young males are more susceptible as a result of their greater occupational exposure to contaminated water sources [2 , 10 , 16 , 17] . Saleem et al [11] reported SCS in 8 male patients, whose mean age was 16.7 years.…”

Section: Discussionmentioning

confidence: 99%

“…Patients who present with severe compression symptoms or who fail medical treatment should consider laminectomy for spinal cord decompression [8] . Resection of the granulomatous lesion is controversial with variable advice, as some think it does more damage and others insist on its effectiveness [8 , 11 , 13 , 16] .…”

Section: Discussionmentioning

confidence: 99%

“…Praziquantel, the cornerstone of schistosomiasis treatment, is an effective agent for all species of schistosoma [14 , 15] , and although no controlled studies exist, steroids are recommended to limit the mass effect and an acute allergic reaction related to Praziquantel treatment in SCS [2 , 9 , 10] . The role of surgical therapy is controversial, but it is required in cases of severe neurological complications and to obtain a pathological sample [8 , 16] .…”

Section: Introductionmentioning

confidence: 99%

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Arborized pattern of MRI enhancement in spinal cord schistosomiasis: A report of 2 successful case outcomes

Abera,

Abdela,

Yaynishet

et al. 2024

Radiology Case Reports

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Arborized pattern of MRI enhancement in spinal cord schistosomiasis: A report of 2 successful case outcomes

Abera,

Abdela,

Yaynishet

et al. 2024

Radiology Case Reports

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“…Although spinal cord involvement by schistosomiasis is considered rare, S. mansoni is known to cause spinal cord disease predominantly [22]. Infections with S. mansoni and S. haematobium typically result in myeloradicular damage, while infections with S. japonicum primarily lead to cerebral lesions [22]. However, there have been reported cases of spinal NS associated with S. japonicum [23].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Spinal Neuroschistosomiasis in Yemen: An Overlooked Dilemma in an Endemic Region

Aljuma'ai,

Ghabisha,

Ahmed

et al. 2023

Cureus

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Background: Neurological involvement in schistosomiasis presents a significant and serious complication. While the disease is generally considered treatable during the early stages, the rarity of this condition often leads to delays in diagnosis and treatment. This study aims to report the clinical characteristics of pediatric patients with spinal neuroschistosomiasis (NS) in an endemic area to the disease.Methods: A retrospective cross-sectional review was conducted at Althora General Hospital in Ibb, Yemen, from January 2016 to January 2021. The study examined confirmed pediatric cases of spinal NS, analyzing their clinical characteristics, laboratory and radiological data, treatment approaches, and complications.Results: The study identified 10 cases of spinal NS with a mean age of 10.1± 3.2 years. The majority (90%) were male and from rural areas, all with a history of freshwater exposure, a known risk factor for schistosomiasis. The average time from presentation to treatment was 33.4± 45.6 days (7-150 days). Common symptoms observed in all patients were bladder dysfunction and paresthesia (100%). Intestinal dysfunction was prevalent in 90% of cases, while 80% exhibited limb weakness or inability to walk. The diagnosis was confirmed through cerebrospinal fluid (CSF) serology in 80% of cases, and stool and urine exams yielded positive results in 90% and 30% of cases, respectively. Magnetic Resonance Imaging findings revealed medullary lesions in 50% of cases, cauda equina lesions in 20%, and multiple lesions in 30%. All patients received oral praziquantel and high-dose steroids for at least three days as part of their initial treatment. During the average follow-up period of 5.6±1.7 months, one patient experienced lower extremity paraplegia, while two cases (20%) showed partial improvement with residual deficits including urinary and fecal incontinence. Complete resolution of symptoms was achieved in seven cases (70%).Conclusion: Schistosomiasis should be considered in pediatric patients with myeloradicular manifestations, especially in endemic areas. Early identification can be achieved through history, prompt imaging, and CSF serology. In the absence of immediate test results, expert-guided presumptive therapy should be considered to minimize neurological complications.

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Acute infectious myelopathies

Isada

Miller

2020

Current Opinion in Infectious Diseases

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Purpose of review The patient who presents with an acute spinal cord syndrome with weakness/paralysis of the limbs presents a diagnostic. Two important syndromes are acute transverse myelitis (ATM) and acute flaccid paralysis (AFP). Both can be caused by a number of infectious and noninfectious causes. Since 2014 there have been outbreaks of acute flaccid myelitis (a subgroup of AFP) in the United States, with a national surveillance program underway. In addition, there have been increasing reports of ATM from new and emerging pathogens, and opportunistic infections in immunocompromised hosts. Recent findings Infectious causes of ATM or AFP need to be ruled out first. There may be important clues to an infectious cause from epidemiologic risk factors, immune status, international travel, MRI, and laboratory findings. We summarize key features for the more common pathogens in this review. Advances in laboratory testing have improved the diagnostic yield from cerebrospinal fluid, including real-time polymerase chain reaction, metagenomic next-generation sequencing, and advanced antibody detection techniques. These tests still have limitations and require clinical correlation. Summary We present a syndromic approach to infectious myelopathies, focusing on clinical patterns that help narrow the diagnostic possibilities.

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Spinal schistosomiasis: Cases in Egyptian population

Cited by 5 publications

References 18 publications

Arborized pattern of MRI enhancement in spinal cord schistosomiasis: A report of 2 successful case outcomes

Arborized pattern of MRI enhancement in spinal cord schistosomiasis: A report of 2 successful case outcomes

Pediatric Spinal Neuroschistosomiasis in Yemen: An Overlooked Dilemma in an Endemic Region

Acute infectious myelopathies

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