Spinal projections of renal afferent nerves in the rat

Knuepfer, Mark M.; Akeyson, Edward W.; Schramm, Lawrence P.

doi:10.1016/0006-8993(88)91292-9

Cited by 32 publications

(5 citation statements)

References 35 publications

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“…This conclusion is reinforced by observations that the laminae in which the Fos expression was observed are the same laminae in which electrophysiological studies have previously reported cells responsive to deep pain. For example, a sampling of spinal neurons responsive to stimulation of A-␦-and C-fibre afferents innervating either the knee (Schaible et al, 1986) or kidney (Knuepfer et al, 1988) revealed significant changes in firing rates of neurons located in laminae I/IIo, IV, V, VI, and VIII. In other studies, restricted to the dorsal horn, cells responsive to deep noxious stimuli were localized predominantly within laminae I and IIo (Milne et al, 1981;Cervero, 1983;Cervero and Tatersall, 1985Mense and Meyer, 1988).…”

Section: Spino-pag Afferents and Deep Painmentioning

confidence: 98%

Spinal sources of noxious visceral and noxious deep somatic afferent drive onto the ventrolateral periaqueductal gray of the rat

et al. 2000

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Studies utilizing the expression of Fos protein as a marker of neuronal activation have revealed that pain of deep somatic or visceral origin selectively activates the ventrolateral periaqueductal gray (vlPAG). Previous anatomical tracing studies revealed that spinal afferents to the vlPAG arose from the superficial and deep dorsal horn and nucleus of the dorsolateral funiculus at all spinal segmental levels, with approximately 50% of vlPAG-projecting spinal neurons found within the upper cervical spinal cord. This study utilized detection of Fos protein to determine the specific populations of vlPAG-projecting spinal neurons activated by noxious deep somatic or noxious visceral stimulation. Pain of cardiac or peritoneal (i.e., visceral) origin activated neurons in the superficial and deep dorsal horn and nucleus of the dorsolateral funiculus of the thoracic cord, whereas pain of hindlimb (i.e., deep somatic) origin activated neurons in the same laminar regions but in the lumbosacral cord. Each of these deep noxious manipulations also activated neurons in the superficial and deep dorsal horn and nucleus of the dorsolateral funiculus of the upper cervical spinal cord. In a second set of experiments, the combination of retrograde tracing and Fos immunohistochemistry revealed that vlPAG-projecting spinal neurons activated by deep somatic pain were located in both the upper cervical and lumbosacral cord, whereas those activated by visceral pain were restricted to the thoracic spinal cord. Thus pain arising from visceral versus deep somatic body regions influences neural activity within the vlPAG via distinct spinal pathways. The findings also highlight the potential significance of the upper cervical cord in integrating pain arising from deep structures throughout the body.

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Section: Spino-pag Afferents and Deep Painmentioning

confidence: 98%

Spinal sources of noxious visceral and noxious deep somatic afferent drive onto the ventrolateral periaqueductal gray of the rat

et al. 2000

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“…Anatomical and physiological studies have demonstrated that renal primary afferent neurons terminate in the spinal cord and in the brainstem (45,52,(54)(55)(56)(57). Interestingly, comparison of immunolabeling for the immediate early gene cFos (a marker for neuronal activation) in the spinal cord following occlusion of the renal artery or vein demonstrated different patterns of distribution of cFos-labeled neurons, suggesting that these two perturbations engage distinct dorsal horn circuits for processing of renal sensory input (58).…”

Section: Anatomy Of the Neural Pathways From The Kidney To The Brainmentioning

confidence: 99%

Function of Renal Nerves in Kidney Physiology and Pathophysiology

Osborn

Tyshynsky

Vulchanova

2021

Annu. Rev. Physiol.

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Renal sympathetic (efferent) nerves play an important role in the regulation of renal function, including glomerular filtration, sodium reabsorption, and renin release. The kidney is also innervated by sensory (afferent) nerves that relay information to the brain to modulate sympathetic outflow. Hypertension and other cardiometabolic diseases are linked to overactivity of renal sympathetic and sensory nerves, but our mechanistic understanding of these relationships is limited. Clinical trials of catheter-based renal nerve ablation to treat hypertension have yielded promising results. Therefore, a greater understanding of how renal nerves control the kidney under physiological and pathophysiological conditions is needed. In this review, we provide an overview of the current knowledge of the anatomy of efferent and afferent renal nerves and their functions in normal and pathophysiological conditions. We also suggest further avenues of research for development of novel therapies targeting the renal nerves.

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“…Jacob et al (2005) suggested that renal afferent nerves play a role in DOCA–salt hypertension because salt intake was decreased in renal denervated rats compared with sham‐operated rats. Renal afferents traverse dorsal roots T10–L1 (Knuepfer et al 1988). Bilateral dorsal rhizotomy of these nerves did not prevent sodium‐dependent hypertension (Kopp et al 2003).…”

mentioning

confidence: 99%

Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)–salt hypertension in rats

Yemane

Busauskas

Burris

et al. 2009

Experimental Physiology

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This brief review describes the role of neural and non-neural mechanisms during different phases of deoxycorticosterone acetate (DOCA)-salt hypertension. There are contradictory data for and against a role of the sympathetic nervous system and neurohumoral agents, including endothelin and vasopressin. Elucidating the factors responsible for DOCA-salt hypertension will be helpful in understanding the causes of hypertension resulting from hypervolaemia, hyperaldosteronism and high salt intake.

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Spinal projections of renal afferent nerves in the rat

Cited by 32 publications

References 35 publications

Spinal sources of noxious visceral and noxious deep somatic afferent drive onto the ventrolateral periaqueductal gray of the rat

Spinal sources of noxious visceral and noxious deep somatic afferent drive onto the ventrolateral periaqueductal gray of the rat

Function of Renal Nerves in Kidney Physiology and Pathophysiology

Neurohumoral mechanisms in deoxycorticosterone acetate (DOCA)–salt hypertension in rats

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