Spinal Neurocysticercosis Manifesting as Recurrent Aseptic Meningitis

Boulos, Mark I.; Aviv, Richard I.; Lee, Liesly

doi:10.1017/s0317167100051635

Cited by 11 publications

(6 citation statements)

References 15 publications

(22 reference statements)

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“…The degree of involvement and stage vary from arachnoiditis mostly in the cauda equina, minimal involvement with one or few cysts, to mass effects resulting in paralysis or uncommonly numerous cysts. [55]…”

Section: Symptomatic Diseasementioning

confidence: 99%

Diagnosis and treatment of neurocysticercosis

Nash

Garcı́a²

2011

Nat Rev Neurol

208

201

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Neurocysticercosis, a major cause of acquired seizures and epiilepsy, is caused by infection with the larval cystic form of the tapeworm, Taenia solium. CT and MRI imaging, development of sensitive and specific diagnostic methods, and discovery of relatively effective anti-cestode drugs, revolutionized knowledge of the burden of infection and disease and led to effective treatments. Here we review the rationale of treatment, the essential role of inflammation in the genesis of disease and its exacerbation as a result of anti-parasitic treatment, and limitations in the efficacy of current anti-parasitic and anti-inflammatory treatments. The importance of “end stage” calcified granulomas as foci of seizures and epilepsy with and without perilesional edema in endemic populations has recently been recognized. New information indicates perilesional inflammation around some calcified foci is associated with seizures and perilesional edema, which suggests that anti-inflammatory treatments may play a role in controlling or preventing epilepsy in these patients. Most importantly, neurocysticercosis is one of the few diseases that can be eradicated, an accomplishment that would prevent millions of cases of epilepsy.

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Section: Symptomatic Diseasementioning

confidence: 99%

Diagnosis and treatment of neurocysticercosis

Nash

Garcı́a²

2011

Nat Rev Neurol

208

201

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“…Rarely, patients with benign tumors or intracerebral cystic abnormalities have developed recurrent meningitis. 6 In our patient, autoimmune serology and neuroimaging were normal or negative. His CSF was typical for DIAM, as it usually shows mononuclear, often lymphocyte-predominant, pleocytosis, elevated protein, and normal glucose.…”

mentioning

confidence: 53%

“…For instance, an unusual case of spinal neurocysticercosis presenting with recurrent aseptic meningitis after a prolonged incubation period has been reported. 5,6 Autoimmune diseases such as systemic lupus erythematosus, Behçet's disease, and sarcoidosis are infrequently complicated by recurrent aseptic meningitis. Malignancy should be ruled out.…”

mentioning

confidence: 99%

Recurrent Amoxicillin-Induced Aseptic Meningitis

Chu

Eustace

2018

Can. J. Neurol. Sci.

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“…By the end of the 20th Century, Sheth et al 18,19 reported partial results of a series of 29 patients with neurocysticercosis evaluated at the University of Toronto from 1991 to 1997; the authors, however, did not give details on the citizenship of their patients. During the new millennium, a number of case reports have confirmed the sporadic occurrence of this parasitic disease in Canada, always in immigrants from endemic areas [21][22][23][24][25][26][27] . In the London Health Sciences Center (Ontario), a retrospective review of all admissions from 1994 to 2004 revealed four patients with neurocysticercosis 22,23 .…”

Section: Discussionmentioning

confidence: 99%

A Review of Cases of Human Cysticercosis in Canada

Brutto

2012

Can. J. Neurol. Sci.

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Objective:Review of human cysticercosis in Canada, to estimate the magnitude of the disease and to describe the pattern of disease expression in this country.Methods:MEDLINE and manual search of case reports and case series of patients with cysticercosis diagnosed in Canada. Abstracted data included year of diagnosis, citizenship status, clinical manifestations, and form of cysticercosis.Findings:A total of 21 articles reporting 60 patients were found. Forty (67%) of these patients were diagnosed in the past two decades. Most cases came from Ontario (n=43) and Quebec (n=14). Immigrants accounted for 96% of the 28 cases in whom citizenship information was available. Neurocysticercosis was observed in 55 patients, and isolated compromise of striated muscles in the remaining five. Seizures was the primary or sole manifestation of the disease in 72% of patients, and most of them had parenchymal brain cysticerci (either viable cysts or calcifications). Two of seven patients were positive for Taenia eggs. In no case were household contacts of the patients investigated for taeniasis.Conclusions:An increasing number of patients with cysticercosis have been reported from Canada in the past two decades, suggesting that the prevalence of this parasitic disease may be on the rise. While most cases occur in immigrants, it is possible that at least some of these patients had acquired the disease in Canada.

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Spinal Neurocysticercosis Manifesting as Recurrent Aseptic Meningitis

Cited by 11 publications

References 15 publications

Diagnosis and treatment of neurocysticercosis

Diagnosis and treatment of neurocysticercosis

Recurrent Amoxicillin-Induced Aseptic Meningitis

A Review of Cases of Human Cysticercosis in Canada

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