Spinal microcircuits go through multiphasic homeostatic compensations in a mouse model of motoneuron degeneration
Filipe Nascimento,
M. Görkem Özyurt,
Kareen Halablab
et al.
Abstract:SummaryIn neurological conditions affecting the brain, early-stage neural circuit adaption is key for long-term preservation of normal behaviour. We tested if motoneurons and respective microcircuits also adapt in the initial stages of disease progression in a mouse model of progressive motoneuron degeneration. Using a combination ofin vitroandin vivoelectrophysiology and super-resolution microscopy, we found that, preceding muscle denervation and motoneuron death, recurrent inhibition mediated by Renshaw cell… Show more
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