Spinal Metastatic Melanoma with Unknown Primary Lesions Presenting as Radiculopathy: Case Report and Literature Review

Tang, Shenghui; Zuo, Junhua; Zhang, Haonan; Wu, Zhanglin; Liang, Biru

doi:10.1016/j.wneu.2020.05.067

Cited by 5 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 13 , 23 , 24 Immunopositivity for S100, vimentin, and/or human melanoma black 45 (HMB-45) have proven useful in supporting cytological diagnosis. 15 , 22 Li et al found vimentin to be significantly upregulated in a mouse model of melanoma metastatic to the lung, also implicating its potential as a biomarker for hematogenous spread. 25 HMB-45 is an anti-melanoma antibody signifying active melanosome formation, and therefore helps to confirm diagnosis of melanoma.…”

Section: Methods and Resultsmentioning

confidence: 99%

“… 5 , 6 While clinical symptoms vary, pain (e.g., back, radicular) tends to be the most common (75–82%) presenting feature, and neurologic deficits (e.g., weakness, paresthesia, incontinence) are seen in 17–21% of patients. 4 , 5 , 15 One cohort study comprising patients from ten different countries reported a higher incidence of metastatic spinal melanoma in the West compared to in Asian countries. 16 …”

Section: Methods and Resultsmentioning

confidence: 99%

“… 11 While metastatic spinal melanoma presents in relatively young patients, who likely are reasonable surgical candidates, prognosis remains quite poor and spinal metastasis is typically a manifestation of widely disseminated disease from a biologically aggressive tumor. 6 , 15 Thus, neurosurgeons should remain mindful of the aforementioned factors predicting worse overall survival, as well as critical in their recommendation of aggressive surgical intervention.…”

Section: Methods and Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Epidemiology, management, and treatment outcomes of metastatic spinal melanoma

Zheng

Soldozy

Mulligan

et al. 2023

World Neurosurgery: X

View full text Add to dashboard Cite

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

Section: Methods and Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology, management, and treatment outcomes of metastatic spinal melanoma

Zheng

Soldozy

Mulligan

et al. 2023

World Neurosurgery: X

View full text Add to dashboard Cite

“…It may occur in every part of the central nervous system, especially the junctions of the cortex and medulla. The MRI signal performance of it is similar to that of primary melanoma and is also related to bleeding and the content of melanin in tumor tissue [ 25 , 26 ]. In this study, 30 cases of metastatic melanoma occurred in the brain, most of which were close to the brain surface, and a small portion were located in the deep part of the brain, with various MRI manifestations.…”

Section: Discussionmentioning

confidence: 99%

Diffusion‐Weighted Imaging Combined with Perfusion‐Weighted Imaging under Segmentation Algorithm in the Diagnosis of Melanoma

Shi

Zhao

et al. 2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

This study is aimed at exploring the value of magnetic resonance diffusion-weighted imaging (DWI) combined with perfusion-weighted imaging (PWI) for diagnosing melanoma under a three-dimensional (3D) hybrid segmentation algorithm. 40 patients with melanoma were collected as research objects and subjected to magnetic resonance imaging (MRI) examination. A segmentation model was constructed and the original images were input. The noise contained in the images was preprocessed and normalized, and the mixed level set segmentation was performed after linear fusion of the images. Imaging findings were analyzed to find that the combined diagnosis of DWI and PWI with a 3D hybrid segmentation algorithm had the advantage of being clear and accurate. 10 primary cases were detected, which occurred in the cerebral meninges; 30 cases of metastases occurred inside the skull, mostly adjacent to the surface of the brain. The typical T1-weighted imaging (T1WI) and T2-weighted imaging (T2WI) of melanoma showed high signal and low signal, respectively, and the enhanced scan showed obvious enhancement. Atypical melanoma was manifested variously in MRI; a few had cystic necrosis, and an enhanced scan of the solid area revealed significant enhancement. Patients with multiple metastatic melanomas mainly showed low signal on DWI, and patients with primary or single metastatic melanoma mainly showed high signal or mixed high signal. Patients with perfusion imaging showed high perfusion on PWI. The 3D hybrid segmentation algorithm helped to improve the accuracy of DWI combined with PWI in the diagnosis of melanoma. This work provided a certain reference for the clinical diagnosis of melanoma.

show abstract

“…As in our case, melanoma is one of the aggressive, highly metastatic tumors through which the leptomeningeal spread to the spine can occur. 1,2 When the metastatic tumor compresses the neural structures, symptoms of myelopathy or radiculopathy can develop. Early surgical intervention to remove the tumor and decompress the spinal cord is warranted to prevent permanent neurodeficits and subsequent complications.…”

Section: Discussionmentioning

confidence: 99%

Anterior Transcorporeal Approach for Cervical Metastatic Melanoma Resection Guided by O-Arm–Navigated Intraoperative Computed Tomography

Jitpakdee

Kotheeranurak

Lim

et al. 2021

Operative Neurosurgery

View full text Add to dashboard Cite

BACKGROUND:Surgical resection of the ventrally located tumor in the cervical spinal region is technically challenging and usually requires a traditional extensive approach. To reduce collateral injury and preserve cervical stability, the anterior transcorporeal approach under navigated guidance is an alternative minimally invasive technique.OBJECTIVE:To describe a minimally invasive transcorporeal approach for cervical intradural extramedullary tumor resection and spinal cord decompression. Previous literature regarding available treatment options was reviewed.METHODS:A patient with known intracranial malignant melanoma presented with severe myelopathy from metastatic melanoma compressing the cervical cord. The anterior transcorporeal approach for total tumor resection and spinal cord decompression under a microscope was planned. Under spinal navigation, small bone tunneling was performed to expose and remove the tumor without compromising cervical stability.RESULTS:The melanoma resection was successfully performed without complications. Myelopathic symptoms were significantly improved with the absence of instability or local recurrence at the long-term follow-up.CONCLUSION:We present the anterior transcorporeal approach that can be used to resect the tumor in the ventral cervical region and effectively decompress the cervical cord without complications. Moreover, this approach is the minimally invasive surgical technique that preserves spinal stability, minimizes bleeding, and shortens the hospital stay.

show abstract

Spinal Metastatic Melanoma with Unknown Primary Lesions Presenting as Radiculopathy: Case Report and Literature Review

Cited by 5 publications

References 13 publications

Epidemiology, management, and treatment outcomes of metastatic spinal melanoma

Epidemiology, management, and treatment outcomes of metastatic spinal melanoma

Diffusion‐Weighted Imaging Combined with Perfusion‐Weighted Imaging under Segmentation Algorithm in the Diagnosis of Melanoma

Anterior Transcorporeal Approach for Cervical Metastatic Melanoma Resection Guided by O-Arm–Navigated Intraoperative Computed Tomography

Contact Info

Product

Resources

About