Spinal meningiomas: Treatment outcome and long-term follow-up

Kwee, Lucy; Harhangi, Biswadjiet S.; Ponne, G.A.; Kros, Johan M.; Dirven, Clemens; Dammers, Rúben

doi:10.1016/j.clineuro.2020.106238

Cited by 35 publications

(49 citation statements)

References 42 publications

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“…In cases of high grade tumors or tumors that invade the pia/arachnoid, the prognosis tends to be worse and adjuvant therapies must be considered (stereotactic radiosurgery, radiotherapy, and/or chemotherapy) [ 13 ]. While the primary treatment of spinal meningiomas remains surgery, with complete resection of the tumor achievable in most cases, preserving neurological function takes precedence over complete removal of the tumor [ 15 ]. The goal of surgery is primarily complete safe tumor removal and decompression of the spinal cord [ 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Intradural Extramedullary Concurrent Schwannoma and Meningothelial Hyperplasia at C2-C3 Cervical Vertebrae: A Case Report and Review of Literature

Rammal

Marker

2022

Case Reports in Pathology

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Concomitant schwannomas and benign meningothelial proliferations, including meningothelial hyperplasia or meningioma, rarely occur at the same location outside the setting of neurofibromatosis. Herein, we present a rare case of concurrent schwannoma and benign meningothelial hyperplasia concomitantly occurring in the cervical spine of a 69-year-old male patient with no history of any genetic disorder.

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Section: Discussionmentioning

confidence: 99%

Intradural Extramedullary Concurrent Schwannoma and Meningothelial Hyperplasia at C2-C3 Cervical Vertebrae: A Case Report and Review of Literature

Rammal

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2022

Case Reports in Pathology

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“…[ 28 29 ] However, in the case of subtotal excision, multiple lesions, or concurrent/previous cranial meningioma, it is usually recommended by most of the authors. [ 29 30 31 32 ] However, adjuvant radiotherapy after GTR has been suggested by a few authors. [ 33 ] Tao et al .…”

Section: Discussionmentioning

confidence: 99%

A giant nondural-based lumbosacral clear cell meningioma mimicking schwannoma: A case report and review of the literature

et al. 2021

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Spinal clear cell meningiomas (CCMs) are rare and dural-based lesion usually affecting the younger population. We report the rare case of giant nondural-based spinal CCM mimicking schwannoma and review the literature. A literature search was performed at PubMed and Embase until January 1, 2020. A total of 19 cases of nondural-based spinal CCM was reported. The following relevant data were extracted: authors, publication year, patient and tumor characteristics, treatment, and outcome. The mean age of the presentation was 20.58 years. Twelve (63.16%) were female and seven patients (36.84%) were male. The most common location was lumbosacral region 15 (79%). Fifteen (79%) tumors had cranio-caudal dimension ≤2 vertebral level, and only four (21%) tumors had dimension ≥2 vertebral level. Gross total resection (GTR) was performed in 18 (95%) patients and subtotal resection (STR) in 1 patient. Recurrences were reported in five (26.14%) patients. Four of them showed recurrences within 6 months; earliest at 2.3 months in the patient had undergone STR. Our patient is 19-year-old male diagnosed with a lumbosacral intradural lesion. Craniocaudal dimension is ≥2 vertebral level shows the foraminal extension and vertebral scalloping. GTR is performed. Intraoperatively, the tumor has foraminal extension and shows attachment with right S1S2 nerve root. No dural attachment is found. Six-month follow-up magnetic resonance image shows no evidence of disease. Nondural-based spinal CCMs are extremely rare and should be kept as a differential diagnosis in young patients with giant intradural tumor, and whose radiological features suggesting of schwannoma. It affects young patients and usually involves more than one vertebral level. The chances of recurrences and metastasis are always high even after GTR; hence, close follow-up of the entire neuraxis is warranted.

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“…[34] e treatment of SMs is primarily surgical and aims at radical resection. e surgical access and technique Maiuri et al, 2011 [18] 117 59 95 N/A N/A Postalci et al, 2011 [22] 46 52 82 60 91 Nakamura et al, 2012 [20] 68 56 91 144 N/A Riad et al, 2013 [25] 15 67 100 99 100 Iacob, 2014 [12] 32 55 100 24 100 Arima et al, 2014 [1] 23 60 90 N/A 96 Maiti et al, 2016 [17] 38 53 97 51 100 Santos et al, 2018 [29] 51 57.6 86 45.9 96 Raco et al, 2018 [24] 173 55.6 98.8 50.8 93.1 Voldřich et al, 2020 [35] 92 64 92 36 98 Kwee et al, 2020 [14] 166…”

Section: Discussionmentioning

confidence: 99%

“…For statistical analysis, the modified McCormick Grades I -III were considered favorable, while Grades IV -V were deemed unfavorable. [14] Follow-up ranged from 1 to 105 months, median of 43 months, most were discontinued after 24 months.…”

Section: Methodsmentioning

confidence: 99%

Correlations between preoperative clinical factors and treatment outcome of spinal meningiomas – A retrospective study of a series of 31 cases

Davarski

Kitov

Apostolov

et al. 2021

Surgical Neurology International

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Background: The purpose of the current study is to identify the correlations between the most important preoperative clinical factors and the outcome of surgery of spinal meningiomas (SM). Methods: We performed a retrospective analysis of the medical history, clinical, paraclinical, neuroimaging, and surgical protocol data in 31 patients with SM who underwent surgical resection at our institution from January 2011 to July 2020. The degree of resection was assessed on the Simpson scale. The modified McCormick scale was used to monitor the effect and outcome of treatment at admission, discharge, and at further follow-up. Results: The average age of the patients was 65 years (37-78). Vertebral pain and motor deficits were the most common initial symptoms that occurred in 26 (89.6%) and 29 (93.5%) patients, respectively. Sphincter disorders were found in 9 (29%) patients. Total resection (Simpson Grade I – II) was achieved in 29 patients (93.5%). We achieved a favorable outcome (McCormick Gr. I to III) in 93.3% of patients. The degree of the neurological deficit (P = 0.026) and the presence of sphincter disorders (P = 0.009) were the preoperative clinical factors that most significantly correlated with the outcome of treatment. Conclusion: The outcome from the surgical treatment of SM correlated significantly with the degree of the preoperative neurological deficit. Therefore, patients presenting with more severe symptoms are expected to have worse outcomes.

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Spinal meningiomas: Treatment outcome and long-term follow-up

Cited by 35 publications

References 42 publications

Intradural Extramedullary Concurrent Schwannoma and Meningothelial Hyperplasia at C2-C3 Cervical Vertebrae: A Case Report and Review of Literature

Intradural Extramedullary Concurrent Schwannoma and Meningothelial Hyperplasia at C2-C3 Cervical Vertebrae: A Case Report and Review of Literature

A giant nondural-based lumbosacral clear cell meningioma mimicking schwannoma: A case report and review of the literature

Correlations between preoperative clinical factors and treatment outcome of spinal meningiomas – A retrospective study of a series of 31 cases

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