Spinal meningiomas: Surgical outcome and literature review

Riad, Hany; Knafo, Steven; Segnarbieux, F.; Lonjon, Nicolas

doi:10.1016/j.neuchi.2012.10.137

Cited by 60 publications

(56 citation statements)

References 29 publications

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“…Studies that reported at least 20 patients were included. 35 The studies that included spine tumors of more than 1 histopathology were excluded. 6 The reports discussing a subset of spinal meningiomas were excluded as well.…”

Section: Literature Reviewmentioning

confidence: 99%

“…The McCormick grade (or modified McCormick grade), although originally used to classify intramedullary tumors, has been used by many authors for assessment of functional outcome. 3,35,42 A good outcome is generally described by patients who either improved or remained stable in comparison with their preoperative status. Setzer et al found that invasion of the arachnoidpia and preoperative McCormick grade were independent predictors of poor long-term outcome.…”

Section: Functional Outcomementioning

confidence: 99%

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Spinal meningiomas: clinicoradiological factors predicting recurrence and functional outcome

Maiti

Bir

Patra

et al. 2016

FOC

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OBJECTIVE Spinal meningiomas are benign tumors with a wide spectrum of clinical and radiological features at presentation. The authors analyzed multiple clinicoradiological factors to predict recurrence and functional outcome in a cohort with a mean follow-up of more than 4 years. The authors also discuss the results of clinical studies regarding spinal meningiomas in the last 15 years. METHODS The authors retrospectively reviewed the clinical and radiological details of patients who underwent surgery for spinal tumors between 2001 and 2015 that were histopathologically confirmed as meningiomas. Demographic parameters, such as age, sex, race, and association with neurofibromatosis Type 2, were considered. Radiological parameters, such as tumor size, signal changes of spinal cord, spinal level, number of levels, location of tumor attachment, shape of tumor, and presence of dural tail/calcification, were noted. These factors were analyzed to predict recurrence and functional outcome. Furthermore, a pooled analysis was performed from 13 reports of spinal meningiomas in the last 15 years. RESULTS A total of 38 patients were included in this study. Male sex and tumors with radiological evidence of a dural tail were associated with an increased risk of recurrence at a mean follow-up of 51.2 months. Ventral or ventrolateral location, large tumors, T2 cord signal changes, and poor preoperative functional status were associated with poor functional outcome at 1-year follow-up. CONCLUSIONS Spine surgeons must be aware of the natural history and risk factors of spinal meningiomas to establish a prognosis for their patients.

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Section: Literature Reviewmentioning

confidence: 99%

Section: Functional Outcomementioning

confidence: 99%

Spinal meningiomas: clinicoradiological factors predicting recurrence and functional outcome

Maiti

Bir

Patra

et al. 2016

FOC

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“…18 Radiotherapy for meningiomas is occasionally initiated without histological confirmation or for cases in which various factors render biopsy or excision impossible, and unfortunately, these cases were not considered in this study; this mostly affects the results for the outcomes of the radiotherapy-alone group. Such a modality is implemented when surgical treatment is contraindicated 15 or as an adjunct to resection of a malignant or progressively enlarging benign lesion. 3,9,16 In this SEER study, it is unclear if the patients who received radiotherapy alone received this treatment because of extensive disease or because they were medically complicated and not candidates for surgical resection.…”

Section: Fig 1 Spinal Meningioma Incidence As a Function Of Age (Nomentioning

confidence: 99%

“…They present in patients most frequently with both local pain and motor dysfunction, although a median of 38.5% (range 4%-61%) of patients will have an identifiable degree of sphincter dysfunction upon detection. 4,5,7,8,12,[14][15][16][18][19][20]22 When neurologically symptomatic, these lesions normally require surgical resection because slow growth in the confined spinal canal most frequently leads to thoracic myelopathy. Serial observation and stereotactic radiosurgery have been implemented for incidental lesions, although the durability and adverse effects of such management have not yet been established.…”

mentioning

confidence: 99%

“…Serial observation and stereotactic radiosurgery have been implemented for incidental lesions, although the durability and adverse effects of such management have not yet been established. 2,4,5,9,15,16 Although these lesions are seen frequently in clinical practice, little has been established about their epidemiology beyond what can be drawn from the more conventional cranial literature. The objective of this study was to define the incidence, demographic associations, prognosis, and epidemiology of spinal meningiomas through use of the Surveillance, Epidemiology, and End Results (SEER) database.…”

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Effects of sex on the incidence and prognosis of spinal meningiomas: a Surveillance, Epidemiology, and End Results study

Westwick

Shamji

2015

SPI

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OBJECT Most spinal meningiomas are intradural lesions in the thoracic spine that present with both local pain and myelopathy. By using the large prospective Surveillance, Epidemiology, and End Results (SEER) database, the authors studied the incidence of spinal meningiomas and examined demographic and treatment factors predictive of death. METHODS Using SEER*Stat software, the authors queried the SEER database for cases of spinal meningioma between 2000 and 2010. From the results, tumor incidence and demographic statistics were computed; incidence was analyzed as a function of tumor location, pathology, age, sex, and malignancy code. Survival was analyzed by using a Cox proportional hazards ratio in SPSS for age, sex, marital status, primary site, size quartile, treatment modality, and malignancy code. In this analysis, significance was set at a p value of 0.05. RESULTS The 1709 spinal meningiomas reported in the SEER database represented 30.7% of all primary intradural spinal tumors and 7.9% of all meningiomas. These meningiomas occurred at an age-adjusted incidence of 0.193 (95% CI 0.183–0.202) per 100,000 population and were closely related to sex (337 [19.7%] male patients and 1372 [80.3%] female patients). The Cox hazard function for mortality in males was higher (2.4 [95% CI1.7–3.5]) and statistically significant, despite the lower lesion incidence in males. All-cause survival was lowest in patients older than 80 years. Primary site and treatment modality were not significant predictors of mortality. CONCLUSIONS Spinal meningiomas represent a significant fraction of all primary intradural spinal tumors and of all meningiomas. The results of this study establish the association of lesion incidence and survival with sex, with a less frequent incidence in but greater mortality among males.