Spinal Manipulation Reduces Pain and Hyperalgesia After Lumbar Intervertebral Foramen Inflammation in the Rat

Song, Xue-Jun; Gan, Qiang; Cao, Jun‐Li; Wang, Zheng-Bei; Rupert, Ronald L.

doi:10.1016/j.jmpt.2005.10.001

Cited by 61 publications

(58 citation statements)

References 15 publications

(28 reference statements)

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“…Evidence from animal models [25][26][27][28][29] demonstrates that manual therapy applied to rats affects mechanical withdrawal thresholds in areas of the body distant to those being treated, which is consistent with reported clinical findings. Collectively, this clinical and experimental evidence suggests that HVLA-SM alters central processing of sensory input.…”

Section: Key Indexing Termssupporting

confidence: 79%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

ReedWilliam

SozioRandall

PickarJoel

et al. 2014

The Journal of Alternative and Complementary Medicine

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Objective-The objective of this preliminary study was to determine if high-velocity, lowamplitude spinal manipulation (HVLA-SM) thrust duration alters mechanical trunk activation thresholds of nociceptive-specific (NS) lateral thalamic neurons.Methods-Extracellular recordings were obtained from 18 NS neurons located in 2 lateral thalamic nuclei (ventrolateral [n = 12] and posterior [n = 6]) in normal anesthetized Wistar rats. Response thresholds to electronic von Frey anesthesiometer (rigid tip) mechanical trunk stimuli applied in 3 lumbar directions (dorsal-ventral, 45° caudal, and 45° cranial) were determined before and immediately after the delivery of 3 HVLA-SM thrust durations (time control 0, 100, and 400 milliseconds). Mean changes in mechanical trunk activation thresholds were compared using a mixed model analysis of variance.Results-High-velocity, low-amplitude spinal manipulation duration did not significantly alter NS lateral thalamic neurons' mechanical trunk responses to any of the 3 directions tested with the anesthesiometer.Copyright © 2014 by National University of Health Sciences.Submit requests for reprints to: William R Reed, DC, PhD, 741 Brady St, Davenport, IA 52803. (william.reed@palmer.edu). Potential Conflicts of Interest No conflicts of interest were reported for this study Contributorship Information Concept development (provided idea for the research): W.R.R. Design (planned the methods to generate the results): W.R.R., J.G.P., R.S.S. Supervision (provided oversight, responsible for organization and implementation, writing of the manuscript): W.R.R. Data collection/processing (responsible for experiments, patient management, organization, or reporting data): W.R.R., R.S.S. Analysis/interpretation (responsible for statistical analysis, evaluation, and presentation of the results): W.R.R., J.G.P., S.M.O., R.S.S. Literature search (performed the literature search): W.R.R., S.M.O., R.S.S. Writing (responsible for writing a substantive part of the manuscript): W.R.R., S.M.O. Critical review (revised manuscript for intellectual content, this does not relate to spelling and grammar checking): W.R.R., J.G.P., S.M.O., R.S.S.The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author ManuscriptConclusions-This study is the first to examine the effect of HVLA-SM thrust duration on NS lateral thalamic mechanical response thresholds. High-velocity, low-amplitude spinal manipulation thrust duration did not affect mechanical trunk thresholds. Key Indexing TermsManipulation; Spinal; Thalamus; Nociceptive Neuron; Lumbar Vertebrae; ChiropracticSpinal manipulation has been shown to be effective in treating neck and low back pain. [1][2][3] Not only are the neurophysiological mechanisms by which this occurs unknown, but a lack of knowledge also exists regarding the effects of clinician-controlled mechanical application parameters o...

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Section: Key Indexing Termssupporting

confidence: 79%

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

ReedWilliam

SozioRandall

PickarJoel

et al. 2014

The Journal of Alternative and Complementary Medicine

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“…Several small animal models were developed to examine the putative neurophysiological consequences of IVF encroachment (Gu et al, 2008;Song et al, 1999Song et al, , 2006. Gu et al developed and tested a rat model using a 60 ll, unilateral IVF injection of a hemostatic gelatin matrix (SURGIFLOW™), which they argued was close in texture to soft tissues such as herniated discs that are commonly associated with IVF encroachment and radicular pain (Gu et al, 2008).…”

Section: Encroachment Of Ivf or Spinal Canalmentioning

confidence: 99%

“…Song et al evaluated behavioral and electrophysiological consequences of chronic IVF encroachment in a rat model that used surgically implanted stainless steel rods (4 mm long, 0.63 mm diameter) to reduce the dimensions of the left L4 or L5 IVF (Song et al, 2006). They reported hindpaw hyperalgesia and allodynia restricted to the side ipsilateral to the IVF encroachment as well as spontaneous extracellular discharges in the dorsal roots ipsilateral to the compressed DRG.…”

Section: Encroachment Of Ivf or Spinal Canalmentioning

confidence: 99%

The basis for spinal manipulation: Chiropractic perspective of indications and theory

Henderson

2012

Journal of Electromyography and Kinesiology

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“…5 This technique is also referred to as Activator-assisted spinal manipulative therapy (ASMT). 6 Compression fractures, considered the most common fractures of the lumbar spine, occur when a portion of bone is forced into the adjacent segments, driving the end plates together. 7 Vertebral fractures are very common and associated with decreased quality of life according to the American Journal of Roentgenology.…”

Section: Introductionmentioning

confidence: 99%

Chiropractic spinal manipulative therapy for a geriatric patient with low back pain and comorbidities of cancer, compression fractures, and osteoporosis

Roberts¹,

Wolfe

2012

Journal of Chiropractic Medicine

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Objective: The purpose of this report is to describe the response of a geriatric patient with low back pain and a history of leukemia, multiple compression fractures, osteoporosis, and degenerative joint disease using Activator chiropractic technique. Case Report: An 83-year-old man who is the primary caretaker for his disabled wife had low back pain after lifting her into a truck. The patient had a history of leukemia, multiple compression fractures, osteoporosis, and degenerative joint disease. His Revised Oswestry Low Back Pain Disability Questionnaire was 26%, with a 10/10 pain rating at its worst on the Numeric Pain Scale. The patient presented with a left head tilt, right high shoulder, and right high ilium with anterior translation and flexion of the torso and spasm and tenderness from the lower thoracic spine to lumbar spine. Intervention and Outcome: The patient was cared for using Activator Methods protocol. After 8 treatments, the patient was stable and remained stable for 4 months without spasm or tenderness in his spine. His Revised Oswestry score dropped to 6%, with a 4/10 Numeric Pain Scale pain rating when at its worst; and the patient reported being able to take care of his wife. Conclusion: The findings of this case suggest that Activator-assisted spinal manipulative therapy had a positive effect on low back pain and function in an elderly patient with a complex clinical history.

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Spinal Manipulation Reduces Pain and Hyperalgesia After Lumbar Intervertebral Foramen Inflammation in the Rat

Cited by 61 publications

References 15 publications

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

Effect of Spinal Manipulation Thrust Duration on Trunk Mechanical Activation Thresholds of Nociceptive Specific Lateral Thalamic Neurons

The basis for spinal manipulation: Chiropractic perspective of indications and theory

Chiropractic spinal manipulative therapy for a geriatric patient with low back pain and comorbidities of cancer, compression fractures, and osteoporosis

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