Spinal Manifestation of Metastasizing Leiomyosarcoma

Nanassis, K.; Alexiadou-Rudolf, Chariklia; Tsitsopoulos, Parmenion P.

doi:10.1097/00007632-199905150-00011

Cited by 27 publications

(16 citation statements)

References 9 publications

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“…The differential diagnosis of leiomyosarcoma includes tumors such as fibrosarcoma, malignant fibrous histiocytoma and malignant peripheral nerve sheath tumor 6 . Refinements of the immunohistochemical techniques have enabled precise interpretation of the nature of the cells and because metastases mostly involve axial skeleton, ruling them out is an important diagnostic problem 7–9 . We describe here another case of primary leiomyosarcoma of the vertebra, and discuss the clinicopathologic features of this rare tumor.…”

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confidence: 94%

Primary leiomyosarcoma of the vertebra: Case report and review of the literature

Sasaguri¹,

Tanimoto²,

Kimura³

et al. 2003

Pathology International

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A case of primary leiomyosarcoma of a thoracic vertebra associated with a compression fracture in a 75-year-old woman was preoperatively thought to be granulation tissue. Surgical decompression was performed and the histological and immunohistochemical studies established the diagnosis of leiomyosarcoma. Based on the clinical and radiological examinations, metastases were ruled out. Primary leiomyosarcoma of the vertebra is extremely rare and in that site it is considered to have a relatively poor prognosis.

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mentioning

confidence: 94%

Primary leiomyosarcoma of the vertebra: Case report and review of the literature

Sasaguri¹,

Tanimoto²,

Kimura³

et al. 2003

Pathology International

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“…It usually occurs de novo, but in some cases, a history of prior irradiation may be present (5). The tumor spreads most commonly by hematogenous route to the lung (6), thyroid (7), liver (6, 8), brain (9), and bone (6,10). Bronchogenic carcinoma, breast carcinoma, melanoma, and gastrointestinal and urinary tract tumors commonly metastasize to skeletal muscle, but it is an unexpected site of metastasis of leiomyosarcoma (5).…”

Section: Discussionmentioning

confidence: 99%

Rectus abdominalis muscle metastasis from uterine leiomyosarcoma: An unusual case and review of the literature

Güngör¹,

Akbay²,

Aksüt³

et al. 2014

J Turkish German Gynecol Assoc

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“…In the present case, multiple cervical and thoracic vertebrae were involved by osteolytic lesions. Given the rarity of primary spinal leiomyosarcoma (6,7) and the patient’s previous history, the lesions were considered to be of a metastatic type, which was then confirmed by the pathological examination.…”

Section: Discussionmentioning

confidence: 99%

Leiomyosarcoma metastatic to the cervical spine causing a C6 compression fracture: A case report

et al. 2014

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Leiomyosarcoma is a rare malignant tumor derived from smooth muscle cells, which commonly metastasizes to the lungs, liver, kidney, brain and skin. The current study presents the case of a 42-year-old male who presented with progressive neck pain and numbness of the left arm. Spinal computed tomography and magnetic resonance imaging revealed osteolytic lesions of numerous vertebrae (C2, C3, C4, C5, C6, C7, T1 and T2). With regard to the C6 vertebra, total destruction of the vertebral body resulted in vertebral collapse and subsequent spinal cord compression. The patient underwent an anterior C6 corpectomy, reconstruction with a mesh cage filled with polymethyl methacrylate (PMMA) and open PMMA infusion to C5 and C7. The surgical procedure significantly alleviated the symptoms and obtained a reliable reconstruction. The clinical follow-up examination at 13 months was uneventful with the exception of mild numbness of the left hand since the surgery. To the best of our knowledge, this is the first case of leiomyosarcoma recurrence presenting in the cervical spine, and the present study provides insight into the use of a surgical technique that has rarely been used in the cervical spine.

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Spinal Manifestation of Metastasizing Leiomyosarcoma

Abstract: In retrospect, the origin of the leiomyosarcoma that manifested in the thoracic spine of the patient must be reconsidered. Rather than a primary dural leiomyosarcoma, this tumor represented the first evidence of recurrence of a missed diagnosis of early-stage uterine leiomyosarcoma.

Cited by 27 publications

References 9 publications

Primary leiomyosarcoma of the vertebra: Case report and review of the literature

Primary leiomyosarcoma of the vertebra: Case report and review of the literature

Rectus abdominalis muscle metastasis from uterine leiomyosarcoma: An unusual case and review of the literature

Leiomyosarcoma metastatic to the cervical spine causing a C6 compression fracture: A case report

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