Spinal Lymphoma and Pulmonary Filariasis in a Pet Domestic Rabbit (<i>Oryctolagus Cuniculus Domesticus</i>)

Reed, Scott D.; Shaw, Shannon; Evans, Dawn

doi:10.1177/104063870902100215

Cited by 11 publications

(6 citation statements)

References 16 publications

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“…Based on previous literature, our differential diagnosis included inflammatory infectious or neoplastic disorders, with degenerative disc disease being less likely. [1][2][3][4][5][12][13][14] MRI is considered the best imaging modality for investigating spinal diseases in humans and companion animals. In our rabbit, MRI correctly identified the cause of the neuro-…”

Section: Discussionmentioning

confidence: 99%

“…Aetiologies of myelopathies reported in previous literature include vascular causes (ischaemic myelopathy), inflammatory causes (myelitis/meningomyelitis of unknown origin or infectious: Encephalitozoon cuniculi), 1 traumatic causes (fractures and vertebral subluxations) 2 and possibly metabolic causes as part of a wider range of central nervous system signs (lead and zinc intoxications). 3 Additionally, neoplastic causes such as lymphoma and adenocarcinoma 4,5 as well as degenerative causes, such as spondylosis of the lumbar spine and pathologies of the intervertebral disc, have been reported, with the highest prevalence for inflammatory, neoplastic and traumatic myelopathies.…”

Section: Introductionmentioning

confidence: 99%

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Conservative treatment of recurrent intervertebral disc extrusions in a lionhead rabbit

Della Camera,

Sola,

Falzone

2023

Vet Record Case Reports

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A 4‐year‐old lionhead rabbit with an acute onset of abnormal hindlimb gait was presented. L4–S3 neurolocalisation was determined based on clinical findings of paraparesis, bilateral proprioceptive positioning deficits, left pelvic limb hyporeflexia and discomfort during lumbar spine manipulation. The magnetic resonance imaging (MRI) revealed an intervertebral disc extrusion (IVDE) at L4–L5, with mild spinal cord compression. The condition was treated conservatively, with cage rest and non‐steroidal anti‐inflammatory drugs. The rabbit was fully normal after 1 month. Two months later, a relapse of clinical signs was observed. A new MRI study revealed a L5–L6 IVDE with mild spinal cord compression. Conservative treatment was repeated and full recovery was confirmed at 4‐month follow‐ups associated with MRI follow‐up study. To the authors' knowledge, this is the first case report of spontaneous IVDEs in a rabbit, where MRI was used to monitor the effectiveness of the conservative management of the disease in a rabbit.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Conservative treatment of recurrent intervertebral disc extrusions in a lionhead rabbit

Della Camera,

Sola,

Falzone

2023

Vet Record Case Reports

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“…For more specific identification, we performed PCR genotyping using DNA from tissue samples taken from the formalin-fixed uterus, but all PCR reactions were negative for Dirofilaria immitis, Dirofilaria repens, and Dipetalonema reconditum. We believe that our assay could have produced false negative results since DNA samples isolated from formalin-fixed tissue are often unsuitable for PCR analysis (Reed et al 2009). …”

Section: Discussionmentioning

confidence: 99%

Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report

Park¹,

Kim²,

Lee³

et al. 2013

Vet. Med. - Czech

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ABSTRACT:Here we describe a unique uterine mass in a dog with granulomatous lesions caused by filarial larvae from the family Onchocercidae. An 8-year-old female Maltese was presented to a local animal hospital with anorexia, depression, and vaginal discharge. A markedly distended uterus was observed on lateral abdominal radiographs, leading to a clinical diagnosis of pyometra or uterine mass of an unknown origin. During surgery, the left uterine horn contained a 5 cm diameter mass adhered to adjacent soft tissue. On gross inspection, the mass contained numerous white nematodes. Microscopically, this mass was characterised by a granulomatous inflammation of the myometrium and endometrium. Because all of the nematodes were dead, definitive species identification was not possible. However, based on the histologic appearance, these nematodes were tentatively identified as Dirofilaria immitis larvae.

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“…18 Recent reports of lymphoma in rabbits also involved the cecum, spinal cord, and Harderian gland, where tumors were all B cell lymphomas. 14,19,26 Unlike multicentric lymphoma, cutaneous lymphoma is rarely diagnosed in rabbits in the United States. A recent 16year study of pet rabbits in the United States found that trichoblastomas were by far the most common cutaneous neoplasm, with collagenous hamartomas and leporipoxvirus-associated Shope fibromas being the next most frequent cutaneous tumors in pet rabbits.…”

mentioning

confidence: 99%

“…18 Recent reports of lymphoma in rabbits also involved the cecum, spinal cord, and Harderian gland, where tumors were all B cell lymphomas. 14,19,26…”

mentioning

confidence: 99%

Cutaneous Lymphomas in European Pet Rabbits (Oryctolagus cuniculus)

Ritter

Bomhard²,

Wise

et al. 2012

Vet Pathol

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Cutaneous lymphoma is a common skin neoplasm of pet rabbits in Europe but is rarely reported in pet rabbits in North America. These neoplasms have not been previously characterized, nor has the cause for the apparent predilection for cutaneous lymphoma in European pet rabbits compared with North American pet rabbits been investigated. In this retrospective study, the authors morphologically and immunohistochemically characterized 25 cutaneous lymphomas in European pet rabbits according to the World Health Organization classification. Tumors were classified as diffuse large B cell lymphomas, with 14 lymphomas exhibiting a centroblastic/centrocytic subtype and 11 tumors exhibiting a T cell-rich B cell subtype. To investigate a potential viral etiology of these lymphomas, 3 diffuse large B cell and 3 T cell-rich B cell lymphomas were evaluated by polymerase chain reaction for retroviral and herpesviral genes. Neither virus was detected. In contrast to other domestic animals, cutaneous lymphomas in European pet rabbits were highly pleomorphic and frequently contained multinucleated giant cells. Unexpectedly, the second most common subtype was T cell-rich B cell lymphoma, a subtype that is rare in species other than horses. Based on a limited number of samples, there was no support for a viral etiology that would explain the higher incidence of lymphoma in European pet rabbits compared with American pet rabbits. Further investigation into genetic and extrinsic factors associated with the development of these tumors is warranted.

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Spinal Lymphoma and Pulmonary Filariasis in a Pet Domestic Rabbit (Oryctolagus Cuniculus Domesticus)

Cited by 11 publications

References 16 publications

Conservative treatment of recurrent intervertebral disc extrusions in a lionhead rabbit

Conservative treatment of recurrent intervertebral disc extrusions in a lionhead rabbit

Granulomatous metritis caused by suspected Dirofilaria immitis in a dog: a case report

Cutaneous Lymphomas in European Pet Rabbits (Oryctolagus cuniculus)

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