Spinal intradural teratomas: developmental programs gone awry?

Kalani, M. Yashar S.; Iyer, Sudarshan R.; Coons, Stephen W.; Smith, Kris A.

doi:10.3171/2012.8.focus12230

Cited by 19 publications

(9 citation statements)

References 12 publications

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“… 13 The occurrence of intradural spinal teratomas in association with spinal dysraphism is also rare. 14 Teratomas have known to be purely retroperitoneal, entirely intraspinal 3 14 15 16 or can also present as a presacral masses with intradural extension. 2 …”

Section: Discussionmentioning

confidence: 99%

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Mature Cystic Retroperitoneal Teratoma with Well Differentiated Renal Elements: Relation to Spinal Dysraphism

Sinha

Sabharwal

Yadav

et al. 2013

Eur Jnl Ped Surg Reports

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Retroperitoneum is a relatively uncommon site for pediatric teratomas. Rarely, such tumors can have an intraspinal extension and few cases of retroperitoneal teratomas associated with spinal dysraphism have been reported. Teratomas consist of tissues arising from all three embryonic layers. However, mature renal tissues in the form of glomeruli and tubules are sparingly found in teratomas. A 15-day-old female presented with spina bifida occulta and on evaluation a cystic presacral mass was detected. Intraoperatively the cyst was found densely adherent to the hemivertebrae but not entering the spinal canal. Histopathological examination confirmed a mature cystic teratoma but also demonstrated presence of mature renal elements in the cyst wall. The teratomas lying in proximity to spine and associated with spinal dysraphism are likely to contain mature renal tissues or even nephroblastic elements. It supports the dysembryogenic model of origin of intradural teratomas from native progenitor cells rather than aberrantly migrated germ cells.

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Section: Discussionmentioning

confidence: 99%

“… 2 Intraspinal teratomas are also rare. 3 Few cases of retroperitoneal teratomas associated with spinal dysraphism have been reported. 4 …”

Section: Introductionmentioning

confidence: 99%

Mature Cystic Retroperitoneal Teratoma with Well Differentiated Renal Elements: Relation to Spinal Dysraphism

Sinha

Sabharwal

Yadav

et al. 2013

Eur Jnl Ped Surg Reports

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“…Sur gi cal re sec tion is the first line treat ment for spi nal teratoma, usu ally decompressive laminectomy is performed [1,42]. The goal of sur gery should al ways be the most rad i cal re moval pos si ble with re lieve of the nerve com pres sion with the aim of pre vent ing pro gres sive de teri o ra tion as re ported in many of the cases [2,4,14,41,43,44]. Com plete re sec tion is also rec om mended for avoid ing im ma ture tis sue or re sid ual ma lig nancy af ter the sur gery [32].…”

Section: Sur Gi Cal Treat Mentmentioning

confidence: 99%

Adult-onset spinal teratoma: a case report and review

Blank¹,

Terbetas²,

Neverauskiene³

et al. 2019

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Teratoma yra apibrėžiama kaip neoplazma, kuri susideda iš įvairių parenchiminių ląstelių, kilusių iš trijų germinacinių sluoksnių (ektodermos, mezodermos ir endodermos). Nugaros smegenų teratomos sudaro 0,1–0,5 % visų nugaros smegenų navikų. Taip pat šis navikas yra itin retas tarp suaugusiųjų. Intramedulinė spinalinė teratoma yra pats dažniausias šio naviko tipas. Pagrindiniai spinalinės teratomos požymiai yra skausmas, kojų silpnumas ir tirpimas, šlaplės ar išangės raukų jos sutrikimas, kai anksti pasireiškia sustiprėję refleksai ir šlapinimosi bei tuštinimosi kontrolės praradimas. Histologinis ištyrimas yra tikslios diagnozės nustatymo auksinis standartas. Teratoma diagnozuojama, stebint audinius, kilusius iš visų trijų germinacinių sluoksnių. Magnetinio rezonanso tyrimas yra auksinis diagnostikos standartas. Dėl naviko audinių įvairovės, MRT vaizduose stebimi nehomogeniško intensyvumo vaizdai T1 ir T2 sekose. Chirurginė rezekcija yra pirmo pasirinkimo gydymas šiam navikui ir dažniausiai atliekama laminektomijos metu. Operacijos tikslas daugeliu atvejų turėtų būti radikali rezekcija su nervų kompresijos sumažinimu, siekiant sumažinti neurologinių funkcijų pablogėjimą. Straipsnio autoriai pristato pirmą intradurinės intramedulinės spinalinės teratomos atvejį Lietuvoje, kuris, nors ir nepasireiškė būdingais simpto mais ir požymiais, tačiau buvo sėkmingai diagnozuotas ir gydytas, taip pat suaugusiųjų spinalinės teratomos literatūros apžvalgą.

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“…3,5 It has been suggested that mesenchymal progenitor cells in the caudal cell mass, which are remnants of the primitive streak and Hensen's node, have a pluripotent nature and are able to differentiate into the tissues derived from all 3 germ layers and cause teratoma formation. 5,6 Supposing that mesenchymal cells are the cause does not explain the association between teratomas and dysraphisms. Instead, we suggest neural crest cells (NCCs) as the cause of these defects.…”

Section: 13mentioning

confidence: 99%

“…The classic model of teratoma formation is based on the misplacement of primordial germ cells from the primitive yolk sac. 5,6,11 Many Fig. 1.…”

Section: 13mentioning

confidence: 99%

Sacrococcygeal teratoma with intradural extension: case report

Shahjouei¹,

Hanaei²,

Nejat³

et al. 2015

PED

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Intradural sacrococcygeal teratoma (SCT) is a rare entity that has been reported in only a few cases previously. The authors present the case of a 2-week-old, otherwise healthy neonate with a mass in the buttock. The imaging findings and the high level of serum alpha-fetoprotein were highly suggestive of SCT. On operation the authors found intradural extension of the teratoma. The lesion was managed successfully without any remaining sequelae. The authors briefly review the currently proposed etiology regarding teratoma formation and the intradural extension of SCT.

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Spinal intradural teratomas: developmental programs gone awry?

Cited by 19 publications

References 12 publications

Mature Cystic Retroperitoneal Teratoma with Well Differentiated Renal Elements: Relation to Spinal Dysraphism

Mature Cystic Retroperitoneal Teratoma with Well Differentiated Renal Elements: Relation to Spinal Dysraphism

Adult-onset spinal teratoma: a case report and review

Sacrococcygeal teratoma with intradural extension: case report

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