Spinal intradural extramedullary bizarre parosteal osteochondromatous proliferation of bone (Nora's Lesion): First case report

Alkhayri, Abdu; Bugdadi, Abdulgadir; Alsalmi, Sultan; André, Ana

doi:10.4103/ajns.ajns_163_18

Cited by 3 publications

(4 citation statements)

References 6 publications

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“…BPOP is a rare benign surface lesion most commonly present in the hands and feet, followed by the long bone. In the literature, unusual localizations have also been reported [ 5 , 7 - 9 ]. To our knowledge, this is the first reported case involving the scapula.…”

Section: Discussionmentioning

confidence: 99%

“…To date, over 200 cases of BPOP have been documented in the literature, with the hands and feet being the most common sites, followed by the long bones [ 1 , 3 ]. Other rare sites have also been reported, such as the skull, maxilla, mandible, sesamoid bone, and vertebrae [ 1 , 5 , 7 - 9 ]. In this report, we present the first case of BPOP involving the scapula, specifically the scapular spine.…”

Section: Introductionmentioning

confidence: 99%

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Unusual Site of a Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) Involving the Scapula: First Case Report and Review of the Literature

Samargandi¹

2023

Cureus

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Bizarre parosteal osteochondromatous proliferation (BPOP), also known as Nora's lesion, is a rare benign surface lesion of bone that typically occurs in the hands and feet. We report herein the first case of BPOP occurring in an unusual location, specifically the scapula of a 29-year-old male patient. The lesion exhibited features mimicking those of a peripheral chondrosarcoma because of its atypical location in the axial skeleton and the presence of calcification, which indicates the presence of cartilaginous matrix. Treatment involved a wide surgical resection, and histopathological examination confirmed the diagnosis of BPOP of the bone. At a five-year follow-up, there was no evidence of local recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Unusual Site of a Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) Involving the Scapula: First Case Report and Review of the Literature

Samargandi¹

2023

Cureus

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“…8 patients suffered from Nora lesions localized in their head bones [33], including mandible (4; 1,2%) [75][76][77][78], maxilla (1; 0.3%) [79], zygoma (1; 0.3%) [80], and nose (1; 0.3%) [81]. Only one case of spine localization has been described in literature to this date [82]. Lesion's localization was not provided for 4 cases: 3 by Nora et al in 1983 and for 1 by Cocks et al in 2018 [1,7].…”

Section: Epidemiologymentioning

confidence: 99%

“…This opened to the idea that the disease could also be found in proximal regions. In the years that followed, several case reports and case series [ 3 - 82 ] increased the number of known cases which had the same clinical, radiographic and histological characteristics described by Nora et al [ 1 ], with a certain share of lesions involving also the proximal skeleton. In light of this evidence, the disease was definitely accepted as a separate entity and is now commonly referred to as the “Bizarre Parosteal Osteochondromatous Proliferation” or “Nora lesion”, in honor of its discoverer.…”

Section: Introductionmentioning

confidence: 99%

Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion): A Narrative Review

Ipponi

Ferrari

Ruinato

et al. 2022

AML

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Background: Bizarre parosteal osteochondromatous proliferation (BPOP), or Nora lesion, is a rare proliferative disease arising from the parosteal region of bones. Although BPOP’s pathogenesis is still not certain, modern literature suggests it to be a tumor-like lesion or even a benign neoplasm. Due to the extremely low incidence, to this date studies on the topic are limited to case reports and a few case series. This narrative review aims to resume literature on BPOP and provide an overview of its natural history, morphologic characteristics and prognostic horizon.Materials and methods: A systematic research of the literature was done to identify studies reporting on patients who suffered from BPOP between 1983 and 2021. We collected data regarding aetiologic and pathogenetic theories, patients’ personal data and anamnesis, lesions’ location, clinical presentation, imaging features, pathological appearance, treatment and prognosis.Results: We identified 322 cases of BPOP with a mean age of 34.3 years at the moment of diagnosis. There was no gender difference. The most involved site was the hand, followed by the foot. A history of trauma was reported for 14.7% of the cases. 38.7% of the patients had pain. Literature defined typical radiographic and microscopic patterns that characterize Nora lesions. While imaging is fundamental to orientate towards BPOP, histological evaluation is mandatory to get the definitive diagnosis. To this date, only reliable therapeutic option is represented by surgical resection. BPOP is burdened by a risk of recurrence that accounts to 37.4%.Conclusion: BPOP is a rare benign disease that should be considered during the differential diagnosis of parosteal lesions, especially in the acral regions. Careful diagnostic evaluations are necessary to get the correct diagnosis and wide margins of resection are recommended to minimize the relatively high risk of local recurrence.

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Bizarre Parosteal Osteochondromatous Proliferation - A Case Report

Singh¹,

Kour²

2023

Apollo Medicine

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Background: Nora's lesion is a benign osteochondromatous proliferation involving the surface of the bone; it presents as exophytic outgrowths very rarely found in the spinal cord. To our knowledge, only one other case of spinal intradural extramedullary bizarre parosteal osteochondromatous proliferation has been reported. Case Presentation: We report the case of a 20-year-old female who presented with paraparesis for the last 2 years. We operated on her and removed the lesion, pressing the cord; the patient had dramatically improved postoperatively, with near total recovery after 6 months. Bizarre parosteal osteochondromatous was reported on histopathological examination. Conclusion: As it is rare, so thus needs to be said.

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Spinal intradural extramedullary bizarre parosteal osteochondromatous proliferation of bone (Nora's Lesion): First case report

Cited by 3 publications

References 6 publications

Unusual Site of a Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) Involving the Scapula: First Case Report and Review of the Literature

Unusual Site of a Bizarre Parosteal Osteochondromatous Proliferation (Nora’s Lesion) Involving the Scapula: First Case Report and Review of the Literature

Bizarre Parosteal Osteochondromatous Proliferation (Nora Lesion): A Narrative Review

Bizarre Parosteal Osteochondromatous Proliferation - A Case Report

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