Spinal Growth Modulation with Use of a Tether in an Immature Porcine Model

Newton, Peter O.; Upasani, Vidyadhar V.; Farnsworth, Christine L.; Oka, Richard; Chambers, Reid; Dwek, Jerry R.; Kim, Jung Ryul; Perry, Andrew; Mahar, Andrew

doi:10.2106/jbjs.g.01424

Cited by 95 publications

(55 citation statements)

References 25 publications

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“…In the present study, a swine model was selected to explore spinal growth modulation because the size and anatomy of the vertebrae, discs, and chest closely resemble those of adolescent humans [12], whereas the extremely rapid growth of this model would maximize the potential for spinal deformity created because of growth [13]. In a EF, elastic fixation; MF, metal rod fixation.…”

Section: Discussionmentioning

confidence: 99%

Spinal growth modulation with posterior unilateral elastic tether in immature swine model

Liu

Shen

et al. 2015

The Spine Journal

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Section: Discussionmentioning

confidence: 99%

Spinal growth modulation with posterior unilateral elastic tether in immature swine model

Liu

Shen

et al. 2015

The Spine Journal

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“…In orthopaedics, porcine models are often used to validate experimental surgical procedures as the growth rate, size and anatomy of the piglet are similar to those of juvenile and adolescent humans [1,5]. In addition, swine, like most mammals, present a second ossification center between growth plates and intervertebral disks.…”

Section: Methodsmentioning

confidence: 99%

Optical coherence tomography for the identification of musculoskeletal structures of the spine: a pilot study

Beaudette¹,

Strupler²,

Benboujja³

et al. 2012

Biomed. Opt. Express

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Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional deformity of the spine requiring in severe cases invasive surgery. Here, we explore the potential of optical coherence tomography (OCT) as a guiding tool for novel fusionless minimally invasive spinal surgeries on an ex vivo porcine model. We show that OCT, despite its limited penetration depth, may be used to precisely locate structures such as growth plate, bone and intervertebral disk using relative attenuation coefficients. We further demonstrate a segmentation algorithm that locates growth plates automatically on en-face OCT reconstructions.

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“…113,114 Vertebral body stapling and anterior spinal tethering are currently being investigated as potential fusionless treatment methods to manage progressive curves. 114,115 The goal of these treatments is to control the patient's remaining spinal growth to achieve curve correction by exploiting the Hueter-Volkmann principle. The convex growth plates are compressed under tension, inhibiting their growth, while the concave growth plates continue to grow, hence straightening the spine.…”

Section: Future Trendsmentioning

confidence: 99%

Adolescent idiopathic scoliosis: current perspectives

Miyanji¹

2014

ORR

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Adolescent idiopathic scoliosis (AIS) remains a common and potentially severe musculoskeletal disorder. Although its etiology is largely unknown, ongoing research endeavors continue to improve our understanding of its potential origin and its natural history. Advances in understanding its true three-dimensional nature have sought to improve classification and management strategies. This review will attempt to highlight and give an overview of the current concepts in adolescent idiopathic scoliosis. Keywords: AIS, current, natural history, management strategies EtiologyThe current consensus on adolescent idiopathic scoliosis (AIS) maintains that it has a multifactorial etiology with genetic predisposing factors. Numerous theories continue to span a broad range of plausibilities in the etiopathogenesis of AIS. To date, the literature has focused on genetic links, metabolic and hormonal disturbances, growth asymmetry, central nervous system alterations, and mechanical and connective tissue abnormalities.Multiple reports support the role of inheritance in the development of AIS. Population studies of index patients and their families have reported on an overall risk of inheritance. They suggest an 11% risk to first-degree relatives, 2.4% risk to second-degree relatives, and 1.4% to third-degree relations.1 A meta-analysis of different twin studies found a 73% concordance rate in monozygotic twins compared to 36% in dizygotic twins.2,3

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Spinal Growth Modulation with Use of a Tether in an Immature Porcine Model

Cited by 95 publications

References 25 publications

Spinal growth modulation with posterior unilateral elastic tether in immature swine model

Spinal growth modulation with posterior unilateral elastic tether in immature swine model

Optical coherence tomography for the identification of musculoskeletal structures of the spine: a pilot study

Adolescent idiopathic scoliosis: current perspectives

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