Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats

Park, Junghyun; Han, Jae-Bok; Kim, Sun-Kwang; Park, Jung-Hyuk; Go, Donghyun; Sun, Boram; Min, Byung-Il

doi:10.1016/j.brainres.2010.02.001

Cited by 48 publications

(43 citation statements)

References 36 publications

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“…At a neuroendocrine level acupuncture modulates various neurotrophins and growth factors including NGF [47], glial-derived neurotrophic factor (GDNF) [48–50], brain-derived neurotrophic factor (BDNF) [51, 52], and insulin growth factor (IGF) [53]. It is possible that the action of acupuncture on neuropathic pain be mediated by enhancement of spinal/central GABA-ergic, serotoninergic, and adrenergic neurotransmission [54–58] as well as by the action of acupuncture on the NGF system, driving NGF signalling toward its downregulation with parallel decrease in sensory neurons hypersensitization [59]. Thus, acupuncture can modify the expression of different genes and the expression of genes that control transcriptional factors that are crucial for cell homeostasis [60].…”

Section: Discussionmentioning

confidence: 99%

A Systematic Review of Experimental and Clinical Acupuncture in Chemotherapy-Induced Peripheral Neuropathy

Franconi

Manni

Schröder

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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Chemotherapy-induced peripheral neuropathy (CIPN) is a common side effect that can be very disabling and can limit or delay the dose of chemotherapy that can be administered. Acupuncture may be effective for treating peripheral neuropathy. The aim of this study was to review the available literature on the use of acupuncture for CIPN. The systematic literature search was performed using MEDLINE, Google Scholar, Cochrane Database, CINHAL, and ISI Proceedings. Hand searching was conducted, and consensus was reached on all extracted data. Only papers in the English language were included, irrespective of study design. From 3989 retrieved papers, 8 relevant papers were identified. One was an experimental study which showed that electroacupuncture suppressed CIPN pain in rats. In addition, there were 7 very heterogeneous clinical studies, 1 controlled randomised study using auricular acupuncture, 2 randomized controlled studies using somatic acupuncture, and 3 case series/case reports which suggested a positive effect of acupuncture in CIPN. Conclusions. Only one controlled randomised study demonstrated that acupuncture may be beneficial for CIPN. All the clinical studies reviewed had important methodological limitations. Further studies with robust methodology are needed to demonstrate the role of acupuncture for treating CIPN resulting from cancer treatment.

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Section: Discussionmentioning

confidence: 99%

A Systematic Review of Experimental and Clinical Acupuncture in Chemotherapy-Induced Peripheral Neuropathy

Franconi

Manni

Schröder

et al. 2013

Evidence-Based Complementary and Alternative Medicine

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“…First, Park et al conducted research to investigate whether spinal GABAergic receptors are involved in the relieving effects of EA on cold allodynia in a rat tail model of neuropathic pain [35]. EA stimulation was applied to “Zusanli” (ST36) and rats were intrathecally injected with gabazine (GABA A receptor antagonist, 0.0003, 0.001, or 0.003 μ g) or saclofen (GABA B receptor antagonist, 3, 10, or 30 μ g).…”

Section: Endogenous Opioids and Descending Inhibitory Systemmentioning

confidence: 99%

“…So far, the mechanisms of EA on spinal endogenous opioidergic [28–31] adrenergic and serotonergic [32], cholinergic [33, 34], and GABAergic [35] systems have been clarified as a result of these studies, and efforts to clarify further mechanisms are on their way [36]. …”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Electroacupuncture-Induced Analgesia on Neuropathic Pain in Animal Model

Kim

Min

2013

Evidence-Based Complementary and Alternative Medicine

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Neuropathic pain remains as one of the most difficult clinical pain syndromes to treat. Electroacupuncture (EA), involving endogenous opioids and neurotransmitters in the central nervous system (CNS), is reported to be clinically efficacious in various fields of pain. Although multiple experimental articles were conducted to assess the effect of EA-induced analgesia, no review has been published to assess the efficacy and clarify the mechanism of EA on neuropathic pain. To this aim, this study was firstly designed to evaluate the EA-induced analgesic effect on neuropathic pain and secondly to guide and help future efforts to advance the neuropathic pain treatment. For this purpose, articles referring to the analgesic effect of acupuncture on neuropathic pain and particularly the work performed in our own laboratory were analyzed. Based on the articles reviewed, the role of spinal opioidergic, adrenergic, serotonergic, cholinergic, and GABAergic receptors in the mechanism of EA-induced analgesia was studied. The results of this research demonstrate that μ and δ opioid receptors, α 2-adrenoreceptors, 5-HT1A and 5-HT3 serotonergic receptors, M1 muscarinic receptors, and GABAA and GABAB GABAergic receptors are involved in the mechanisms of EA-induced analgesia on neuropathic pain.

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“…These effects have been demonstrated in the nervous system and other tissues in animal models of metabolic, neurological and inflammatory disorders [15][16][17][18][19][20][21][22]. The efficacy of acupuncture and electroacupuncture in neuropathic pain [12,23] and their actions on the inhibitory neurotransmitter γ-aminobutyric acid (GABA) [24] have also been reported. Interestingly, GABA has a role in the generation and maintenance of diabetesinduced sensory dysfunctions [25,26] and the activitydependent regulation of spinal NGF synthesis [27].…”

Section: Introductionmentioning

confidence: 99%

“…Our analysis was done by measuring NGF, tyrosine kinase A (TrkA) and its phosphorylated form, SP, TRPV1 and GABA protein contents in the hindpaw skin and spinal cord, these two tissues being sites of the peripheral and central actions of electroacupuncture in modulating neuropathic pain [23,24,31]. The tissue distribution of TrkA was also analysed to further explore the structures involved in NGF signalling.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats

2011

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Aims/hypothesis Diabetes is considered the leading cause of neuropathies in developed countries. Dysfunction of nerve growth factor (NGF) production and/or utilisation may lead to the establishment of diabetic neuropathies. Electroacupuncture has been proved effective in the treatment of human neuropathic pain as well as in modulating NGF production/activity. We aimed at using electroacupuncture to correct the development of thermal hyperalgesia and the tissue alteration of NGF and sensory neuromodulators in a rat model of type 1 diabetes. Methods Adult rats were injected with streptozotocin to induce diabetes and subsequently treated with lowfrequency electroacupuncture for 3 weeks. Variation in thermal sensitivity was studied during the experimental course. Hindpaw skin and spinal cord protein content of NGF, NGF receptor tyrosine kinase A (TrkA), substance P (SP), transient receptor potential vanilloid 1 (TRPV1) receptor and glutamic acid decarboxylase-67 (GAD-67) were measured after electroacupuncture treatments. The skin and spinal cord cellular distribution of TrkA was analysed to explore NGF signalling. Results Early after streptozotocin treatment, thermal hyperalgesia developed that was corrected by electroacupuncture. The parallel increases in NGF and TrkA in the spinal cord were counteracted by electroacupuncture. Streptozotocin also induced variation in skin/spinal TrkA phosphorylation, increases in skin SP and spinal TRPV1 and a decrease in spinal GAD-67. These changes were counteracted by electroacupuncture. Conclusions/interpretation Our results point to the potential of electroacupuncture as a supportive therapy for the treatment of diabetic neuropathies. The efficacy of electroacupuncture might depend on its actions on spinal/peripheral NGF synthesis/utilisation and normalisation of the levels of several sensory neuromodulators.

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Spinal GABA receptors mediate the suppressive effect of electroacupuncture on cold allodynia in rats

Cited by 48 publications

References 36 publications

A Systematic Review of Experimental and Clinical Acupuncture in Chemotherapy-Induced Peripheral Neuropathy

A Systematic Review of Experimental and Clinical Acupuncture in Chemotherapy-Induced Peripheral Neuropathy

Mechanisms of Electroacupuncture-Induced Analgesia on Neuropathic Pain in Animal Model

Electroacupuncture counteracts the development of thermal hyperalgesia and the alteration of nerve growth factor and sensory neuromodulators induced by streptozotocin in adult rats

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