Biochemical Pharmacology volume 78, issue 8, P1026-1034 2009 DOI: 10.1016/j.bcp.2009.06.106 View full text
Takaaki Komatsu, Shinobu Sakurada, Kazuhiro Kohno, Hideo Shiohira, Sou Katsuyama, Chikai Sakurada, Minoru Tsuzuki, Tsukasa Sakurada

Abstract: Intrathecal (i.t.) injection of morphine-3-glucuronide (M3G), a major metabolite of morphine without analgesic actions, produces a severe hindlimb scratching followed by biting and licking in mice. The pain-related behavior evoked by M3G was inhibited dose-dependently by i.t. co-administration of tachykinin NK(1) receptor antagonists, sendide, [D-Phe(7), D-His(9)] substance P(6-11), CP-99994 or RP-67580 and i.t. pretreatment with antiserum against substance P. The competitive NMDA receptor antagonists, D-APV a…

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