Spinal Drop Metastasis from a Posterior Fossa Choroid Plexus Papilloma

Ahn, Soon-Seob; Cho, Young-Dae

doi:10.3340/jkns.2007.42.6.475

Cited by 12 publications

(10 citation statements)

References 18 publications

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“…Such metastases are particularly associated with primary tumours in the posterior fossa and occur within a few years after the primary diagnosis 2 3 5. From 1980 until 2010, 22 case reports described metastasis from CPP 1 – 3 5 – 8. Over 75% of these cases showed spinal seeding with locoregional tumour-recurrence, similar to our case 3.…”

Section: Discussionsupporting

confidence: 81%

Atypical transformation in sacral drop metastasis from posterior fossa choroid plexus papilloma: Figure 1

et al. 2012

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Correspondence to Mischa Stuivenvolt, m.stuivenvolt@elisabeth.nl SummaryChoroid plexus papillomas (CPP) are rare tumours and spinal metastases of CPP are even less common. We report a 50-year-old woman with spinal drop metastases at Th9 and S1-2 6 years after total resection of a posterior fossa CPP. The metastasis at S1-2 was resected and histological examination showed transformation to an atypical CPP. Atypical transformation in a metastasis years after resection of a benign posterior fossa CPP has been described once. We would like to advocate craniospinal MRI at the time of initial diagnosis as well as periodic follow-up after total and subtotal resection of a posterior fossa CPP in adults at least once in 1 or 2 years, depending on the histological grading of the primary CPP. In our case report, this could have resulted in earlier diagnosis of the locoregional recurrence or of the spinal drop metastasis. BACKGROUND

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Section: Discussionsupporting

confidence: 81%

Atypical transformation in sacral drop metastasis from posterior fossa choroid plexus papilloma: Figure 1

et al. 2012

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“…Yet, in adult patients, there are several examples demonstrating that benign CPP can form distant metastases. [1][2][3][4][5][6][8][9][10][12][13][14][16][17][18][19][22][23][24][25][26][27][31][32][33][34][35][36]38,39 A review of the literature demonstrated 35 cases in adults (age range 19-74 years, mean 40.3 years; 14 males, 19 females, and 2 patients in whom sex and age were not reported) ( Table 1). These included cases in which the metastatic…”

Section: Discussionmentioning

confidence: 99%

“…lesions demonstrated progression to atypical CPPs 26,33,38 or retained benign features similar to those of the original primary lesion. 1,2,4,9,[16][17][18]22,23,25,27,31,33,39 Furthermore, these metastatic lesions were found within the ventricular sys-tem, posterior fossa (including the cerebellopontine angle), or anterior or middle cranial fossa; diffusely involving the leptomeninges; or along the spinal axis.…”

Section: Fig 2 Photomicrographs Amentioning

confidence: 99%

Spinal drop metastasis from a benign fourth ventricular choroid plexus papilloma in a pediatric patient: case report

Morshed

Lau

Sun

et al. 2017

Journal of Neurosurgery: Pediatrics

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Choroid plexus papillomas (CPPs) are typically benign tumors that can occur in any age group but are more commonly found in pediatric patients. Although these tumors are benign, there are several reports in adult patients of distant metastases present either at the time of diagnosis or occurring months to years after initial resection. Here, the authors report the case of a 14-year-old boy who presented with symptoms of elevated intracranial pressure due to obstructive hydrocephalus that was caused by a large fourth ventricular mass. Preoperative imaging included a full MRI of the spine, which revealed an intradural lesion that encased the distal sacral nerve roots at the tip of the thecal sac and was concerning for a drop metastasis. The patient underwent gross-total resection of both the fourth ventricular and sacral tumors with histology of both lesions consistent with benign CPP (WHO Grade I). In addition, the authors review prior reports of both pediatric and adult patients in whom benign CPPs have metastasized with either benign or atypical pathology found at a distant site. Taking into account this unusual case and reports in the literature, patients with even benign CPPs may warrant initial and routine follow-up imaging of the total neural axis in search of the rare, but possible, occurrence of drop metastasis.

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“…(11) Spinal drop metastasis can occur. (12) Symptoms are due to hydrocephalus or parenchymal invasion. Signal characteristics and enhancement do not distinguish benign from malignant.…”

Section: Discussionmentioning

confidence: 99%

Role of Mri in Evaluation of Posterior Fossa Tumours With Histopathological Correlation

Durai¹,

Ganesan²,

Selvaganapathy³

et al. 2016

jemds

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Posterior fossa extends from tentorium cerebelli to foramen magnum and posterior fossa tumours are more common in children than in adults. Since posterior fossa is a critical location with limited space, even small tumours produce significant morbidity and mortality. The advent of Magnetic Resonance Imaging (MRI) has revolutionised the diagnosis and management of brain tumours. OBJECTIVESTo study the demographic profile and assess the distribution, features, localisation, and extent of posterior fossa neoplasms by MRI and to correlate the tissue characterisation by MRI with that of histopathological examination. MATERIALS AND METHODSA prospective study was done on 90 patients who were diagnosed to have posterior fossa neoplasm by magnetic resonance imaging from January 2014 to November 2015. They were followed up till surgery or biopsy for confirmatory histopathological diagnosis. The final diagnosis were correlated followed by analysis of the present study by comparing with previous similar studies from various literature. RESULTSThere was an overall male predominance with Male: Female ratio of 1.5:1. Among adults, extra-axial tumours (68%) were more frequent than intra-axial ones (32%) with vestibular schwannoma (37%) being the commonest lesion. Most common intra-axial tumour was metastasis (13%) and most common primary intra-axial tumour was haemangioblastoma (8%). Among paediatric age group, intra-axial tumours (83%) were commoner than extra-axial ones (17%) with low-grade astrocytoma (38%) as the commonest lesion followed by medulloblastoma (29%) and ependymoma (17%). Overall, 6 cases were misdiagnosed by MRI as glioma and turned out to be tuberculoma CONCLUSIONMRI proves to be a valuable modality of imaging in accurately evaluating the morphologic distribution of various intra-and extra-axial tumours in the posterior fossa. MRI can correctly diagnose 100% of extra-axial tumours and 85% of intra-axial lesions. Main tumour mimics of posterior fossa are tuberculoma and pyogenic abscess.

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Spinal Drop Metastasis from a Posterior Fossa Choroid Plexus Papilloma

Cited by 12 publications

References 18 publications

Atypical transformation in sacral drop metastasis from posterior fossa choroid plexus papilloma: Figure 1

Atypical transformation in sacral drop metastasis from posterior fossa choroid plexus papilloma: Figure 1

Spinal drop metastasis from a benign fourth ventricular choroid plexus papilloma in a pediatric patient: case report

Role of Mri in Evaluation of Posterior Fossa Tumours With Histopathological Correlation

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