Spinal cord stimulation in heart failure: effect on disease‐associated biomarkers

Naar, Jan; Jaye, Deborah A.; Linde, Cecilia; Neužil, Petr; Doškář, Petr; Málek, Filip; Braunschweig, Frieder; Lund, Lars H.; Mortensen, Lise Saksø; Bäck, Magnus; Linderoth, Bengt; Lind, Göran; Kueffer, Fred; Koehler, Jodi; Shahgaldi, Kambiz; Ståhlberg, Marcus

doi:10.1002/ejhf.702

Cited by 5 publications

(3 citation statements)

References 9 publications

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“…Furthermore, we did not see any beneficial effect of SCS on heart failure-associated biomarkers, i.e. renin-angiotensin-aldosterone hormonal axis activation, levels of circulating inflammation markers or norepinephrine level (Naar et al, 2017b). The main finding of the present study supports the neutral results from the DEFEAT-HF trial and previously published data on sub-groups from the main trial, as decreased sympathetic nerve activity is a fundamental presumption regarding the mechanism of action of SCS in heart failure (Linderoth and Foreman, 1999).…”

Section: Effect Of Scs On the Autonomic Nervous System In Subjects Wi...contrasting

confidence: 60%

Acute effect of spinal cord stimulation on autonomic nervous system function in patients with heart failure

Naar¹,

Jaye²,

Neužil³

et al. 2021

J Appl Biomed

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Aims: To test the hypothesis that spinal cord stimulation (SCS) acutely improves heart rate variability (HRV) and baroreceptor sensitivity (BRS) in patients with heart failure (HF). Methods: SCS (15 minutes) was delivered in four different settings: 90% of maximal tolerated stimulation amplitude (MTA) targeting the T1-T4 spinal cord segments (SCS90T1-4), 60% of MTA (SCS60T1-4), 90% of MTA with cranial (SCS90CR) and caudal (SCS90CA) electrode configuration. HRV and BRS were recorded continuously and stimulation was compared to device off. Results: Fifteen HF patients were included. SCS90T1-4 did not change the standard deviation of intervals between normal beats (SDNN, p = 0.90), BRS (p = 0.55) or other HRV parameters. In patients with baseline SDNN <50 ms, SCS90T1-4 significantly increased SDNN (p = 0.004). Conclusions: Acute SCS at 60-90% of MTA targeting upper thoracic spinal cord segments does not improve autonomic balance or baroreceptor sensitivity in unselected patients with heart failure but may improve HRV in patients with low SDNN.

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Section: Effect Of Scs On the Autonomic Nervous System In Subjects Wi...contrasting

confidence: 60%

Acute effect of spinal cord stimulation on autonomic nervous system function in patients with heart failure

Naar¹,

Jaye²,

Neužil³

et al. 2021

J Appl Biomed

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“…Unstimulated whole buccal saliva was collected from subjects as previously described [1, 4, 5, 16], at the time of the second follow-up visit in 2008. Briefly, saliva was collected during 3 minutes after an overnight fast and without prior oral hygiene measures.…”

Section: Methodsmentioning

confidence: 99%

Differential Associations for Salivary Sodium, Potassium, Calcium, and Phosphate Levels with Carotid Intima Media Thickness, Heart Rate, and Arterial Stiffness

et al. 2018

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Salivary biomarkers may offer a noninvasive and easy sampling alternative in cardiovascular risk evaluation. The aim of the present study was to establish associations of salivary potassium, sodium, calcium, and phosphate levels with the cardiovascular phenotype determined by carotid ultrasound and carotid-femoral pulse wave velocity and to identify possible covariates for these associations. N = 241 samples of nonstimulated whole buccal saliva were obtained from subjects with (n = 143; 59%) or without (n = 98; 41%) hypertension. The potassium concentrations were 10-fold higher in saliva compared with plasma, whereas sodium concentrations exhibited the reverse relation between saliva and blood. There were no significant correlations between the levels of sodium, potassium, or calcium in saliva and plasma. All salivary electrolytes, except sodium, were significantly associated with age. In age-adjusted analyses, salivary potassium was significantly associated with carotid artery intima media thickness (cIMT) and carotid-femoral pulse wave velocity, and these associations were at the limit of significance in multivariate analyses including prevalent cardiovascular disease and risk factors. Body mass index was a significant confounder for salivary potassium. Salivary phosphate was significantly associated with cIMT in the multivariate analysis. Salivary potassium, calcium, and phosphate levels were significantly associated with heart rate in the univariate age-adjusted as well as in two different multivariate models, whereas no significant associations between sodium and heart rate were observed. In conclusion, the differential association of salivary electrolytes with cardiovascular phenotypes indicates that these electrolytes should be further studied for their predictive value as noninvasive biomarkers for cardiovascular risk evaluation.

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“…Their results demonstrated the potential of this approach for improving functional status and symptoms in these patients. Naar et al (52), based on findings in their clinical trial, have also shown the potential benefit of SCS in heart failure and investigated the changes in several cardiac biomarkers before and after SCS. Interestingly, the finding of significant changes in some of them, such as high‐sensitivity troponin T, also suggests that there could also be a type of cardiac injury during stimulation.…”

Section: Applicationsmentioning

confidence: 99%

Biomarker Optimization of Spinal Cord Stimulation Therapies

Nagel

Hsieh

Machado

et al. 2021

Neuromodulation: Technology at the Neural Interface

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Spinal cord stimulation in heart failure: effect on disease‐associated biomarkers

Cited by 5 publications

References 9 publications

Acute effect of spinal cord stimulation on autonomic nervous system function in patients with heart failure

Acute effect of spinal cord stimulation on autonomic nervous system function in patients with heart failure

Differential Associations for Salivary Sodium, Potassium, Calcium, and Phosphate Levels with Carotid Intima Media Thickness, Heart Rate, and Arterial Stiffness

Biomarker Optimization of Spinal Cord Stimulation Therapies

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