Spinal Cord Schistosomiasis: Two Different Outcomes

Alsomaili, Mohammed; Abulaban, Ahmad

doi:10.1159/000443787

Cited by 8 publications

(8 citation statements)

References 6 publications

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“…In light of the results of this study, it can be concluded that normal MCH in patients during the HD process is due to the administration of several drugs that makes mean capsular hemoglobin normal in HD patients (16). Also, in a previous study done on Chittagong HD patients, Chowdhury et al showed that MCH was 28.79±3.77 pg 17 .…”

Section: Hematology Parametersmentioning

confidence: 51%

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Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Humudat

2023

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Anemia is a common consequence of chronic kidney disease (CKD) that is linked to a decrease in patients' quality of life, a rise in morbidity and mortality, and an acceleration in CKD progression. This study aimed to investigate the hematological profile of chronic renal patients undergoing hemodialysis and to correlate the same with anemia. Fifty (54% males and 46% females) with ages ranging from 18-76 years of patients with CKD and on regular maintenance hemodialysis not less than three months at the Iraqi center for dialysis in Baghdad teaching hospital, and 30 healthy adults were recruited into the study. Hemoglobin concentration, red cell count, white blood cell count, platelet count, ESR, CRP and HCV were assessed for the subjects and controls. Results were analyzed using a t-test independent, and the data were retrieved from the laboratory information system in the hospital. Red blood cell count was reduced in nearly all (96%) of the study patients, while ESR was elevated in (98%) and CRP was elevated in (95%). All patients suffered anemia in HD patients. Most of the patients' WBCs and platelet counts were normal. Anti-HCV antibodies were positive in 15 (30%) of these patients, with non-significant differences in both genders. The study concludes that anemia is a significant comorbidity in hemodialysis patients, with several factors contributing to it, and thorough workup and successful treatment of anemia are essential in this group of patients. Keywords: Anemia; Hematological profile; Hemodialysis; Hepatitis; chronic kidney disease

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Section: Hematology Parametersmentioning

confidence: 51%

“…This is likely because changes in plasma volume caused by dialysis machines have a significant impact on red cell sedimentation 11 . However, ESR levels in hemodialysis blood were enhanced by 98%, whereas Alsomaili et al found 79.5 % in patients with chronic renal disease 17 .…”

Section: Hematology Parametersmentioning

confidence: 91%

Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Humudat

2023

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“…and Mohamed et al. reported a similar case in which radiologic findings of intramedullary‐enhancing lesions mimicked spinal cord tumors 6,7 . In Ahmed et al 2 .…”

Section: Discussionmentioning

confidence: 93%

“…2 While post-mortem studies have indicated a three to four times higher prevalence rate of asymptomatic NS cases, 5 the variability of clinical presentation and low index of suspicion can lead to misdiagnosis, even among symptomatic cases. 2,6,7 Herein, we report a case of conus intramedullary NS that mimicked transverse myelitis, and was misdiagnosed as Guillain-Barre syndrome, and subsequently led to delayed treatment and permanent neurological deficit in a 9-year-old boy.…”

Section: Introductionmentioning

confidence: 96%

Conus medullaris neuroschistosomiasis mimicking Guillain–Barre syndrome: A case of delayed diagnosis leading to permanent neurological damage

Aljuma'ai,

Ghabisha,

Ahmed

et al. 2024

Clinical Case Reports

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Key Clinical MessageIn the evaluation of acute flaccid paralysis, particularly in pediatric populations within endemic areas for schistosomiasis infection, clinicians must maintain a high index of suspicion for neuroschistosomiasis. Prompt identification is imperative to mitigate the risk of irreversible neurological sequelae.AbstractSpinal cord involvement in neuroschistosomiasis (NS) is considerably rare, with even fewer reported cases affecting the conus medullaris in children. While NS's neurological sequelae are typically thought to be reversible, delayed diagnosis and treatment can lead to permanent deficits. We report a case of a 9‐year‐old boy who presented with 3 weeks of progressive bilateral lower extremity weakness. A spinal MRI showed patchy gadolinium enhancement in an expanded conus medullaris, leading to a presumed diagnosis of Guillain–Barre syndrome, and the patient was treated with intravenous immunoglobulin. However, the lack of improvement necessitated surgical laminectomy. The post‐operative histopathological examination confirmed the presence of a schistosomal parasite. Despite initiating therapy with corticosteroid and praziquantel, the patient did not exhibit clinical improvement, resulting in persistent flaccid paralysis, bladder, and bowel incontinence. In conclusion, spinal NS should be considered in patients presenting with myeloradicular symptoms in regions endemic for schistosomal infection, as delayed recognition can result in irreversible outcomes.

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“…A progressive neurological decline in the setting of medical treatment failure is an indication of spinal cord biopsy [13]. Some entities on the differential diagnosis of a cervical intramedullary lesion, such as neuroschistosomiasis, are reversible and can be medically treated [14,15]. Schistosoma haematobium and S. mansoni are the most common parasitic infections of the spinal cord, and they can cause acute and chronic spinal complications.…”

Section: Discussionmentioning

confidence: 99%

Primary Spinal Glioblastoma Mimicking Neuroschistosomiasis: A Case Report

McCallum¹,

Khattar²,

Kolikonda³

et al. 2022

Cureus

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Primary glioblastoma of the spinal cord (sGB) is a rare and challenging diagnosis. In the diagnostic algorithm, reversible causes should be considered while the diagnosis of sGB is under evaluation. We present a case of cervical sGB mimicking neuroschistosomiasis.A 21-year-old Somali man presented with neck pain, sensory disturbances, and spastic tetraplegia. Cervical spine magnetic resonance imaging with contrast showed a heterogeneously enhancing intramedullary mass spanning from the level of the C1 to T3 vertebrae. Cerebrospinal fluid analysis showed a lymphocytic predominance and elevated protein. Due to the patient's history of poorly treated schistosomiasis, praziquantel and dexamethasone were initiated while the diagnostic work-up was completed. Three days after the patient was discharged to a rehabilitation facility where he experienced worsened motor function with radiographic progression of the lesion and increased cord edema. The patient underwent a surgical biopsy which confirmed a diagnosis of primary sGB.sGB is an unusual diagnosis that can masquerade as a non-neoplastic lesion. However, the diagnosis of sGB should be considered in patients with an intramedullary spinal cord lesion who exhibit rapid radiographic and clinical progression.

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Spinal Cord Schistosomiasis: Two Different Outcomes

Cited by 8 publications

References 6 publications

Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Assessment of the impact of anemia on hematological parameters among hemodialysis patients with chronic kidney disease

Conus medullaris neuroschistosomiasis mimicking Guillain–Barre syndrome: A case of delayed diagnosis leading to permanent neurological damage

Primary Spinal Glioblastoma Mimicking Neuroschistosomiasis: A Case Report

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