Spinal Cord Physiology of Nociception

Light, Alan R.; Lee, S.

doi:10.1016/b978-012370880-9.00165-1

Cited by 5 publications

(4 citation statements)

References 106 publications

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“…The sensory innervation of the low back is relatively nondetailed and represents a small region of the primary sensory cortex (28–31). Patients cannot typically discriminate among, for example, disc‐related pain, facet pain, or muscle strains due to a lack of discrete sensory input, which suggests that pain signals for this large area must converge onto small targets, in a manner similar to that seen in visceral pain syndromes (32, 33).…”

Section: Anatomy and Physiologymentioning

confidence: 99%

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment

Chapman

Groenen

Vissers

et al. 2021

Neuromodulation: Technology at the Neural Interface

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Section: Anatomy and Physiologymentioning

confidence: 99%

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment

Chapman

Groenen

Vissers

et al. 2021

Neuromodulation: Technology at the Neural Interface

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“…7A) because these neurons are a site of convergent sensory processing that result in encoding intensity of noxious stimulation and project to the spinothalamic tract. 41 Wide-dynamic-range neurons were sought 12 to 14 days after surgery (SNL n 5 12 rats and sham SNL n 5 4) and in naive rats (n 5 7). To allow comparison between different groups, each animal was recorded in a stereotyped fashion with the same number of electrode insertions, lengths of the search path, and uniform incremental electrode advancements (50 mm) that are long enough to avoid duplicate recordings from the same neuron.…”

Section: Impulses From the L5 Level Drive Spontaneous Activity Of Dor...mentioning

confidence: 99%

Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain

Chao

Mecca

et al. 2021

Pain

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Dorsal root ganglion field stimulation (GFS) relieves evoked and spontaneous neuropathic pain by use-dependent blockade of impulse trains through the sensory neuron T-junction, which becomes complete within less than 1 minute for C-type units, also with partial blockade of Aδ units. We used this tool in the spinal nerve ligation (SNL) rat model to selectively block sensory neuron spontaneous activity (SA) of axotomized neurons at the fifth lumbar (L5) level vs blockade of units at the L4 level that remain uninjured but exposed to inflammation. In vivo dorsal root single-unit recordings after SNL showed increased SA in L5 units but not L4 units. Ganglion field stimulation blocked this SA. Ganglion field stimulation delivered at the L5 dorsal root ganglion blocked mechanical hyperalgesia behavior, mechanical allodynia, and ongoing spontaneous pain indicated by conditioned place preference, whereas GFS at L4 blocked evoked pain behavior but not spontaneous pain. In vivo single-unit recordings of spinal cord dorsal horn (DH) wide-dynamic-range neurons showed elevated SA after SNL, which was reduced by GFS at the L5 level but not by GFS at the L4 level. In addition, L5 GFS, but not L4 GFS, increased mechanical threshold of DH units during cutaneous mechanical stimulation, while L5 GFS exceeded L4 GFS in reducing evoked firing rates. Our results indicate that SA in injured neurons supports increased firing of DH wide-dynamic-range neurons, contributing to hyperalgesia, allodynia, and ongoing pain. Ganglion field stimulation analgesic effects after nerve injury are at least partly attributable to blocking propagation of this SA.

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“…While much of the recent attention has been directed to infections as a pathway to ME/CFS [22], less attention has focused on abnormal peripheral input from muscles receptors as a relevant mechanism for ME/CFS fatigue as well as pain. It is possible that specific peripheral fatigue and pain pathways have become sensitized in ME/CFS patients by yet unknown mechanisms (infections, physical and/or psychological stressors) [23–25] and that continuous input from these pathways is necessary to maintain the chronic fatigue state as well as pain.…”

Section: Epidemiology and Public Health Impact Of Chronic Fatigue mentioning

confidence: 99%

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

Staud

2012

Curr Rheumatol Rep

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Fatigue is a common symptom in a large number of medical and psychological disorders including many rheumatologic illnesses. A frequent question for health care providers is related to whether reported fatigue is “in the mind” or “in the body” i.e. central or peripheral. If fatigue occurs at rest without any exertion this suggests psychological or central origins. If patients relate their fatigue mostly to physical activities including exercise then their symptoms can be considered peripheral. However, most fatiguing syndromes seem to depend on both peripheral and central mechanisms. Sometimes muscle biopsy with histochemistry may be necessary for the appropriate tissue diagnosis whereas serological tests generally provide little reliable information about the origin of muscle fatigue. Muscle function and peripheral fatigue can be quantified by contractile force and action potential measurements whereas validated questionnaires are frequently used for assessment of mental fatigue. Fatigue is a hallmark of many rheumatologic conditions including fibromyalgia, myalgic encephalitis/chronic fatigue syndrome, rheumatoid arthritis, systemic lupus, Sjogren’s syndrome and ankylosing spondylitis. Whereas many studies have focused on disease activity as a correlate to these patients’ fatigue it has become apparent that other factors including negative affect and pain are some of the most powerful predictors for fatigue. Conversely sleep problems, including insomnia seem to be less important for fatigue. There are several effective treatment strategies available for fatigued patients with rheumatologic disorders including pharmacological and non-pharmacological therapies

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Spinal Cord Physiology of Nociception

Cited by 5 publications

References 106 publications

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment

The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment

Dorsal root ganglion stimulation of injured sensory neurons in rats rapidly eliminates their spontaneous activity and relieves spontaneous pain

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

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