Spinal Cord is the Primary Site of Action of the Cannabinoid CB2 Receptor Agonist JWH133 that Suppresses Neuropathic Pain: Possible Involvement of Microglia
Abstract:Neuropathic pain, a highly debilitating condition that commonly occurs after damage to the nervous system, is often resistant to commonly used analgesic agents such as non-steroidal anti-inflammatory drugs and even opioids. Several studies using rodent models reported that cannabinoid CB 2 receptor (CB 2 R) agonists are effective for treating chronic pain. However, the analgesic mechanism of CB 2 R agonists in neuropathic pain states is not fully understood. In this study, we investigated the role of CB 2 Rs i… Show more
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