Spinal-cord involvement in the hepato—splenic form of<i>Schistosoma mansoni</i>infection

Ferrari, Teresa C. A.; Moreira, Pedro Costa; Cunha, Aloísio Sales da

doi:10.1080/00034983.2001.11813679

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…Symptomatic NS is very rare either during the acute phase of the infection or in association with the severe chronic clinical forms (Pittella 1997, Ferrari et al 2001. All the forms of symptomatic NS are more prevalent among young men.…”

Section: Clinical Manifestationsmentioning

confidence: 99%

Involvement of central nervous system in the schistosomiasis

Ferrari

2004

Mem. Inst. Oswaldo Cruz

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Section: Clinical Manifestationsmentioning

confidence: 99%

Involvement of central nervous system in the schistosomiasis

Ferrari

2004

Mem. Inst. Oswaldo Cruz

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“…The presence and clinical significance neurological lesions depend on the combination of the presence of eggs and the immune response of the host. In the majority of cases, there occurs a delayed immune response type four or granulomatous, and is higher in the beginning of schistosomiasis, while in chronic forms it becomes localized and lighter (immunological modulation phenomenon) 9,10 . The present report brings some concepts about epidemiological aspects in schistosomal myelitis illness that disrupts the classical view that linked this disease to very prevalent zones for schistosomiasis.…”

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confidence: 99%

Epidemiological aspects in neuroschistosomiasis

Vidal

Gurgel

Ferreira

et al. 2010

Arq. Neuro-Psiquiatr.

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The urbanization process of schistosomiasis has been described in the literature. The present report shows and discusses some epidemiological aspects of neuroschistosomiasis that emphasizes this trend. Method: The study was done between July, 2005 and June, 2006, and consisted of spinal cord schistosomiasis carriers at the moment of diagnosis. These patients were evaluated whatever the origin and period of the year that they developed the symptoms. Results: A total of 13 patients were evaluated. Ten cases (76.92%) came from the Metropolitan Region of Recife, while the other zones (Zona da Mata, Agreste e Sertão) contributed with just three cases (23.07%). October, November and December (post rainy period) concentrated the majority of the cases (61.54%). Conclusion: The high spatial and temporal concentration of cases in relation to a recent endemic area for Schistosomiasis suggests that the immunological status may be an important factor for installation of Sschistosomal myelitis. Key words: epidemiology, schistosomiasis mansoni, neuroschistosomiasis, myelitis. Aspectos epidemiologicos na neuroesquistossomoseReSuMo O processo de urbanização da esquistossomose vem sendo descrito na literatura. O presente estudo apresenta e discute alguns aspectos epidemiológicos na neuroesquistossomose que confirmam essa tendência. Método: O estudo foi realizado entre julho de 2005 e junho de 2006, sendo composto por portadores de mielite esquistossomótica no momento do diagnóstico. Os pacientes foram avaliados quanto à procedência e ao período do ano que desenvolveram a doença. Resultados: No total foram 13 pacientes avaliados, sendo 10 casos (76,92%) provenientes da Região Metropolitana do Recife, enquanto as demais regiões (Zona da Mata, Agreste e Sertão) contribuíram com apenas um caso cada. Os meses de outubro, novembro e dezembro concentraram a maioria dos pacientes (61,54%). Conclusão: A alta concentração espacial e temporal de casos em relação a uma área endêmica recente para esquistossomose sugere que a participação de fatores imunológicos possa ser importante para o desenvolvimento de sua forma medular. Palavras-chave: epidemiologia, esquistossomose mansoni, neuroesquistossomose, mielite.

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“…Through the rectal plexus, there is free communication between the portal and the systemic venous system 10 . With the less severe clinical form of schistosomiasis (intestinal and hepatointestinal), the eggs reach the nervous system through Batson's plexus, and sudden augmentation of abdominal pressure may facilitate this event 8 . A predilection for the lowest spinal cord segments might be caused by the egg's lateral thorn, which may hinder its further migration 11 .…”

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confidence: 99%

“…The NS lesion may occur at any point once the adult female parasite has laid her eggs, between the 27 th and 48 th days of infection. However, NS lesions are more common in the initial clinical systemic forms, during the latent period or during chronic mild forms of the disease [6][7][8] . The presence and clinical significance of neurological lesions depend on the combination of the presence of eggs and the immune response of the host.…”

mentioning

confidence: 99%

Portal Doppler ultrasound evaluation in myelitis by Schistosoma mansoni

Vidal

Gurgel

Ferreira

et al. 2010

Arq. Neuro-Psiquiatr.

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The mechanism for development of schistosomal myelitis has not yet been completely understood. Few publications have tried to establish a link between the general clinical presentation of the illness and its neurological manifestations. Objective: To evaluated the portal blood flow in patients with schistosomal myelitis and controls. Method: Fortythree individuals were evaluated using portal Doppler ultrasound. Group I consisted of 13 patients with the spinal form of schistosomiasis. Group II included 10 patients with intestinal and hepatointestinal forms of schistosomiasis, but no neurological symptoms; while group III involved 20 healthy controls. Results: Portal venous speed and portal venous flow were significantly elevated in group I (p<0.001) compared with the others. Conclusion: Doppler ultrasound demonstrated a situation of high flow within the portal venous system of patients with schistosomal myelitis. Key words: schistosomiasis mansoni, neuroschistosomiasis, myelitis, portal system. Avaliação pela ultrassonografia com Doppler portal na mielite pelo Schistosoma mansoni RESUMOA fisiopatogênese da mielopatia esquistossomótica não é completamente entendida, sendo escassas as publicações que tentam inferir a relação entre a forma clínica da esquistossomose e suas manifestações neurológicas. Objetivo: Avaliar o fluxo sanguíneo do sistema porta em pacientes com mielite esquistossomótica, contribuindo no entendimento dos mecanismos que favorecem a chegada dos parasitas e/ou seus derivados ao sistema nervoso. Método: Foram avaliados 43 indivíduos pela Dopplerfluxometria portal. O grupo I constou de 13 pacientes com esquistossomose medular, sendo o grupo II composto por 10 portadores de formas intestinal e hepatointestinal (sem doença neurológica), e o grupo III, por 20 controles sadios. Resultados: A velocidade venosa portal e o fluxo venoso portal foram significativamente elevados (p-valor<0,001) no grupo I. Conclusão: A Dopplerfluxometria demonstrou a presença de estados hiperdinâmicos do leito vascular porta em pacientes com mielite pelo Schistosoma mansoni. Palavras-chave: esquistossomose mansoni, neuroesquistossomose, mielite, sistema porta.

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Spinal-cord involvement in the hepato—splenic form ofSchistosoma mansoniinfection

Cited by 3 publications

References 8 publications

Involvement of central nervous system in the schistosomiasis

Involvement of central nervous system in the schistosomiasis

Epidemiological aspects in neuroschistosomiasis

Portal Doppler ultrasound evaluation in myelitis by Schistosoma mansoni

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