Spinal Cord Injury Induced Hyperalgesia is Associated with Increased Levels of Let-7 Family of MicroRNAs

Abstract

Title: Spinal cord injury induced hyperalgesia is associated with increased levels of Let-7 family of MicroRNAs.Background: Spinal cord injury (SCI) results in chronic pain syndromes that are often refractory to treatment with opioids, and may represent mu opioid receptor (MOR) dysfunction. MicroRNAs play a role in gene regulation by binding to target mRNA, causing translational repression or mRNA degradation. Let-7 family microRNAs have been shown to target MOR suggesting they may influence the development of pain states and opioid responsiveness. This study sought to determine temporal changes in Let-7 family miRNA and correlate them to the onset of pain behaviors in a rodent model of post-SCI pain.

microRNA let-7i-5p mediates the relationship between muscle fat infiltration and neck pain disability following motor vehicle collision: a preliminary study

“…miR-106-3p has been shown to be involved in neuronal repair following injury 80 , is affected by physiological stress in animals and humans 81 , and is a negative regulator of adipocyte differentiation 56 . Let-7 microRNAs including let-7i-5p and let-7b-3p have been shown to be differentially expressed after stress exposure 51,52,81 , and multiple members of the let-7 family have been shown to be associated with chronic pain 50,[82][83][84][85] . Consistent with our findings indicating that let-7i-5p mediates the relationship between fatty infiltrates in neck muscle and neck-pain disability, let-7i-5p has been shown to influence adipocyte function in both mice and humans 53 .…”