A sample of 199 persons with spinal cord injury (SCI) were assessed on Big Five personality dimensions using the NEO Five-Factor Inventory (NEO-FFI; Costa & McCrae, 1992) at admission to an inpatient medical rehabilitation program. A cluster analysis of the baseline NEO-FFI yielded 3 cluster prototypes that resemble resilient, undercontrolled, and overcontrolled prototypes identified in many previous studies of children and adult community samples. Compared with normative samples, this sample had significantly fewer resilient prototypes and significantly more overcontrolled and undercontrolled prototypes. Undercontrolled individuals were the modal prototype. The resilient and undercontrolled types were better adjusted than the overcontrolled types, showing lower levels of depression at admission and higher acceptance of disability at discharge. The resilient type at admission predicted the most effective reports of social problem-solving abilities at discharge and the overcontrolled type the least. We discuss the implications of these results for assessment and interventions in rehabilitation settings.There are approximately 253,000 persons with spinal cord injury (SCI) in the United States, with around 11,000 new cases each year. The high social and personal costs of SCI are well documented (National Spinal Cord Injury Statistical Center, 2006). Spinal cord injury can touch almost every area of an individual's life, from work, to relationships, to physical and mental health (Dijkers, 2005). Much research has rightly been devoted to assessing the impact of SCI and to the study of factors that may predict subsequent emotional and physical adjustment. Progress has been made in identifying social (Elliott, Bush, & Chen, 2006;Holicky & Charlifue, 1999), functional disability (Waters, Adkins, Yakura, & Sie, 1998), and coping and problem-solving variables (Chan, Lee, & Lieh-Mak, 2000;Elliott, 1999) that are associated with a variety of adjustment outcomes.In contrast with the large literature on coping and adjustment in SCI, few studies have examined basic personality processes among persons with SCI. Psychologists have been encouraged to include basic personality instruments in their clinical assessments (Elliott & Umlauf, 1995). There is good reason to heed this advice: An accumulation of research spanning three decades shows that a few basic personality dimensions, such as the Big Five personality factors (John & Srivastava, 1999), can be reliable predictors of functioning in important domains of life such as vocational achievement (Goodstein & Lanyon, 1999) (Botwin, Buss, & Shackelford, 1997), psychological adjustment and coping (Elliott, Herrick, MacNair, & Harkins, 1994;McCrae, 1991;McCrae & Costa, 1986), overall happiness and satisfaction with life (Costa & McCrae, 1980;Myers & Diener, 1995), and general physical health and wellness behaviors (Booth-Kewley & Vickers, 1994). These are life domains that have been the focus of much research on physical disability and its consequences, but studies that hav...