Spinal cord injury and gut microbiota: A review

Jing, Yingli; Bai, Fan; Yu, Yan

doi:10.1016/j.lfs.2020.118865

Cited by 32 publications

(23 citation statements)

References 123 publications

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“…Finally, it is well recognized that gut microbiota have a great impact in human health [ 47 , 48 ]. Recent studies have shown that neuropathic pain induced by nerve injury [ 49 , 50 ] or by long-term use of morphine [ 51 ] can lead to gut dysbiosis, by altering the composition of the microbiota [ 52 ], thereby impairing intestinal immune function, promoting neurodegenerative diseases such as Alzheimer and Parkinson [ 48 , 53 , 54 ], and aggravating the pain associated with neurodegenerative disease [ 55 ]. Other studies have also demonstrated that fecal microbiota transplantation and treatments with prebiotics and probiotics are potential therapeutic approaches for Alzheimer [ 56 , 57 ] and Parkinson [ 58 , 59 ], by modifying gut microbiota.…”

Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated

et al. 2022

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Recent studies have revealed that hydrogen sulfide (H2S) increases the analgesic actions of the δ-opioid receptor (DOR) in inflammatory pain. However, the possible improvement of the analgesia of μ-opioid receptor (MOR) and DOR agonists during neuropathic pain, through pretreatment with two slow-releasing H2S donors—DADS (diallyl disulfide) and GYY4137 (morpholin-4-ium 4-methoxyphenyl(morpholino) phosphinodithioate dichloromethane complex)—is still unknown. In male C57BL/6J mice with neuropathic pain incited by chronic constriction of the sciatic nerve (CCI), we evaluated: (1) the influence of DADS (3.5 mg/kg) and GYY4137 (0.7 mg/kg) on the inhibition of the allodynia and hyperalgesia produced by the systemic or local administration of morphine (3 mg/kg or 65 µg) and UFP-512 (1 mg/kg or 12.5 µg); (2) the reversion of the antinociceptive actions of high doses of DADS (30 mg/kg) and GYY4137 (24 mg/kg) with MOR and DOR antagonists; and (3) the effects of H2S donors on oxidative stress, apoptotic responses, and MOR and DOR expression in the medial septum (MS) and dorsal root ganglia (DRG). The results revealed that both DADS and GYY4137 improved the antiallodynic effects of morphine and UFP-512, possibly by up-regulating MOR and DOR expression in DRG. The administration of MOR and DOR antagonists blocked the analgesic properties of DADS and GYY4137, revealing the feasible participation of the endogenous opioid system in H2S analgesic effects. Moreover, both H2S donors inhibited oxidative stress and apoptosis generated by CCI in the MS and/or DRG. This study suggests the co-treatment of H2S donors with MOR or DOR agonists as a potential therapy for neuropathic pain.

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Section: Discussionmentioning

confidence: 99%

Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated

et al. 2022

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“…SCI is an acute traumatic disease and involved in multiple functional changes in the central nervous system, which is characterized by dynamic and complex pathological process (Jing et al 2021;Megía García et al 2020). In the occurrence of SCI, ischemia and hypoxia stimulate the release of a large number of oxygen free radicals.…”

Section: Discussionmentioning

confidence: 99%

Stat3-Induced lncRNA Kcnq1ot1 Regulates the Apoptosis of Neuronal Cells in Spinal Cord Injury

et al. 2021

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Emerging evidence validates the vital roles of long noncoding RNAs (lncRNAs) in spinal cord injury (SCI), which attracts great attention. In the present study, our study investigated the function and in-depth mechanism of lncRNA Kcnq1 overlapping transcript 1 (Kcnq1ot1) in SCI. Results indicated that lncRNA Kcnq1ot1 expression upregulated in the hypoxiaadministered neuronal cells (PC12 cells) and SCI rat models. Moreover, transcription factor signal transducer and activator of transcription 3 (Stat3) accelerated the transcriptional enrichment of Kcnq1ot1 in SCI cellular model. Functional experiments demonstrated that Kcnq1ot1 knockdown repressed the apoptosis of neuronal cells. Mechanistically, Kcnq1ot1 recruited EZH2 to the promoter region of p27 to repress its transcription. Taken together, our results indicate that Stat3-induced lncRNA Kcnq1ot1 regulates the apoptosis in SCI through epigenetically silencing p27, contributing to novel therapeutic target for SCI.

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“…The topic of the capacity of the gut microbiome to regulate pain has been the subject of many recent reviews. Table 1 [8,9,11,[32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51] illustrates and summarizes 23 of these review articles that detail a variety of aspects surrounding pain initiation, detection, biochemistry, and management. As captured among these reviews, there has been an explosion of research on this topic over the past five years.…”

Section: Painmentioning

confidence: 99%

Microbiome First Approaches in Pain Prevention and Management

Dietert

2021

AJBSR

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The Microbiome First Initiative aims to facilitate sustainable healthcare by focusing first and foremost on the human holobiont majority, the microbiome. Understanding how the human microbiome affects not only risk of disease but also human perceptions can help individuals thrive and pave the way for a healthy life course. Following a recent review of Microbiome First Medicine the context of health and safety, this present opinion article considers the role of the human microbiome, particularly the gut microbiome, on pain, sensory perceptions, and the prevention and multimodal management of pain. Microbial dysbiosis can be causative of some forms of immune-inflammatory and neurologic pain and the altered human microbiome can lock in the pain while at the same time interfering with analgesic/opioid therapies. Dysbiotic microbiota can make drug treatments less effective and with opioids, the microbes can significantly increase:1. Opioid tolerance 2. The risk of addiction 3. The likelihood of withdrawal failure.For these reasons, it is critical to move beyond simply thinking about the microbiome in dealing with pain to considering the microbiome as central in multimodal pain prevention and management strategies. The microbiome is key in any attempts to change physiology, metabolism, systems biology function, and receptor-based perceptions within the human body.

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Spinal cord injury and gut microbiota: A review

Cited by 32 publications

References 123 publications

Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated

Hydrogen Sulfide Increases the Analgesic Effects of µ- and δ-Opioid Receptors during Neuropathic Pain: Pathways Implicated

Stat3-Induced lncRNA Kcnq1ot1 Regulates the Apoptosis of Neuronal Cells in Spinal Cord Injury

Microbiome First Approaches in Pain Prevention and Management

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