Spinal Cord Injury

Bryce, Thomas N.; Huang, Vincent; Escalón, Miguel X.

doi:10.1016/b978-0-323-62539-5.00049-7

Cited by 8 publications

(2 citation statements)

References 154 publications

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“…Patients with SCI often experience neurological impairment and secondary complications, such as colorectal, bladder and sexual dysfunction (Lynch et al ., 2001 ; Anderson, 2004 ). Over two‐thirds of all patients with SCI will develop symptoms of intestinal dysfunction, such as faecal incontinence or constipation, leading to neurogenic intestinal dysfunction (Bryce et al ., 2021 ). Intestinal dysfunction not only impairs the dignity and quality of life of patients but also aggravates neurological damage (White and Holmes, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats

Cheng

Liu

Wang

et al. 2021

Microbial Biotechnology

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Spinal cord injury (SCI) is a disease involving gastrointestinal disorders. The underlying mechanisms of the potential protective effects of electroacupuncture (EA) and 5-hydroxytryptamine (5-HT) system on SCI remain unknown. We investigated whether EA improves gut microbial dysbiosis in SCI and regulates the 5-HT system. 16S rDNA gene sequencing was applied to investigate alterations in the gut microbiome of the rats. Faecal metabolites and the expression of the 5-HT system were detected. EA and faecal microbiota transplantation (FMT) treatment facilitated intestinal transmission functional recovery and restored the colon morphology of SCI rats. The composition of the intestinal microbiota, including numbers of phylum Proteobacteria, class Clostridia, order Bacteroidales, and genus Dorea, were amplified in SCI rats, and EA and FMT significantly reshaped the intestinal microbiota. SCI resulted in disturbed metabolic conditions in rats, and the EA and FMT group showed increased amounts of catechin compared with SCI rats. SCI inhibited 5-HT system expression in the colon, which was significantly reversed by EA and FMT treatment. Therefore, EA may ameliorate SCI by modulating microbiota and metabolites and regulate the 5-HT system. Our study provides new insights into the pathogenesis and therapy of SCI from the perspective of microbiota and 5-HT regulation.

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Section: Introductionmentioning

confidence: 99%

Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats

Cheng

Liu

Wang

et al. 2021

Microbial Biotechnology

View full text Add to dashboard Cite

show abstract

“…The pathological process of SCI is complex, and once it occurs, it leads to the loss or severe impairment of motor, sensory, and autonomic functions. 76,77 The existence of the blood–spinal cord barrier (BSCB) creates challenges in facilitating the access of numerous drugs employed for SCI treatment to the specific site of spinal cord injury. Consequently, the selection of an effective drug delivery system to improve treatment outcomes has become a hot topic in current research.…”

Section: Micro/nanomotors For Neuromodulationmentioning

confidence: 99%