Spinal cord compression in &lt;FONT FACE=Symbol&gt;b&lt;/font&gt;-thalassemia: follow-up after radiotherapy

Fonseca, Silvana Fahel da; Figueiredo, Maria Stella; Cançado, Rodolfo Delfini; Nakandakare, Fernando; Segreto, Roberto Araújo; Kerbauy, J

doi:10.1590/s1516-31801998000600009

Cited by 3 publications

(2 citation statements)

References 2 publications

(7 reference statements)

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“…Gatto in 1954 was the first to report spinal cord compression by EMH. [ 2 ] Cases can present with paraparesis, sensory impairment, and occasionally sphincter disturbances. Paraplegia or quadriplegia may ensue.…”

Section: Discussionmentioning

confidence: 99%

Thoracic cord compression by extramedullary hematopoiesis in thalassemia

Hashmi

Guha²,

Sengupta

et al. 2014

Asian J Neurosurg

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Extramedullary hematopoiesis (EMH) refers to hematopoiesis occurring outside the medulla of bone. It may be physiologic or due to pathological conditions like hematopoietic disorders. EMH can involve liver, spleen, thorax, and lymph nodes. It can involve paraspinal tissues with extension and involvement of spinal canal. In our case, the diagnosis was confirmed by the history of the patient stating underlying hematological condition and by magnetic resonance imaging (MRI) findings showing large soft tissue masses in paraspinal areas with involvement of spinal canal and leading to cord compression.

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Section: Discussionmentioning

confidence: 99%

Thoracic cord compression by extramedullary hematopoiesis in thalassemia

Hashmi

Guha²,

Sengupta

et al. 2014

Asian J Neurosurg

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“…2 Extramedullary hematopoiesis should be suspected in patients with hematologic disorders and spinal cord compression symptoms. 7 Most of the patients present with progressive paraparesis due to slow expansion of the extramedullary hematopoietic tissue. 8 Clinical recognition is important for early diagnosis, and prevention of irreversible neurologic complication in such cases.…”

Section: Discussionmentioning

confidence: 99%

Spinal Cord Compression Secondary to Extramedullary Hematopoiesis: Case Report and Summary

Zamanizadeh¹,

Eghbali

Taghipour³

et al. 2006

Neurosurgery Quarterly

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Extramedullary hematopoiesis is a common compensatory phenomenon to chronic hemolytic anemias. It may be seen in many other conditions including bloody dyscrasias such as leukemia, or as an incidental finding. Common locations of the extramedullary hematopoiesis are liver, spleen, lymph nodes. Spinal cord compression is a rare complication of this entity. We report a spinal cord compression due to extramedullary hematopoiesis. Clinical presentation, diagnosis, and therapeutic options are discussed.

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Effect of hydroxyurea on extramedullary haematopoiesis in thalassaemia intermedia: case reports and literature review

Meo

Cassinerio

Castelli

et al. 2008

Int J Lab Hematology

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Extramedullary haematopoiesis (EH) is the production of blood cell precursors outside the bone marrow that occurs in various disorders, such as thalassaemia, sickle cell anaemia, hereditary spherocytosis, polycythaemia vera, myelofibrosis and other haematological diseases. In chronic anaemia, it is a physiological response to increased erythropoietin. In some other conditions, such as myeloid metaplasia, polycythaemia vera or chronic myeloid leukaemia, EH is due to a clonal disorder of haematopoiesis that enables progenitor cells to escape from the marrow and lodge in other organs. EH usually involves the liver, spleen and lymph nodes or it can be paravertebral, intrathoracic, pelvic. It is often asymptomatic but can sometimes lead to symptomatic tumour-like masses. Treatment options are still controversial and limited, including hypertransfusion regimen, surgical treatment, radiotherapy and hydroxyurea (HU). We describe intrathoracic and symptomatic pelvic EH masses in a 48-year-old woman and intrathoracic bilateral masses causing respiratory insufficiency with pleural effusion in a 42-year-old male, both affected by thalassaemia intermedia. Both patients showed a clinical improvement with hydroxyurea therapy and occasional blood transfusions.

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Spinal cord compression in <FONT FACE=Symbol>b</font>-thalassemia: follow-up after radiotherapy

Abstract: Extramedullary hematopoiesis should be investigated in patients with hematologic disorders and spinal cord symptoms. The rapid recognition and treatment with radiotherapy can dramatically alleviate symptoms.

Cited by 3 publications

References 2 publications

Thoracic cord compression by extramedullary hematopoiesis in thalassemia

Thoracic cord compression by extramedullary hematopoiesis in thalassemia

Spinal Cord Compression Secondary to Extramedullary Hematopoiesis: Case Report and Summary

Effect of hydroxyurea on extramedullary haematopoiesis in thalassaemia intermedia: case reports and literature review

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