Spinal cord compression in a cat due to vertebral angiomatosis

Schur, David; Rademacher, Nathalie; Vasanjee, Sunil; McLaughlin, Leslie D.; Gaschen, Lorrie

doi:10.1016/j.jfms.2009.10.003

Cited by 17 publications

(39 citation statements)

References 9 publications

(6 reference statements)

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“…Impression smears were obtained for cytology in one case report and, although samples were described of low cellularity with a poor degree of cellular preservation, cytologic findings were similar to those described in the present case, consisting in well‐differentiated osteoblasts and osteoclasts, but no evidence of malignancy or inflammation . Cytologic findings described are highly unspecific and therefore, in the absence of inflammatory or neoplastic cells, could be compatible with other processes in which bone remodeling occurs, such as osteoma or callous formation after bone fracture in addition to vertebral angiomatosis.…”

Section: Discussionsupporting

confidence: 71%

“…Five cases of vertebral angiomatosis have been previously described in cats with no cases reported in dogs . In all cases, the animals were under 2 years old at presentation.…”

Section: Discussionmentioning

confidence: 99%

“…The 2 cases discharged after surgical treatment reached complete remission of clinical signs after 3 and 4 months postoperatively, respectively . The main differential diagnoses of extradural compression of the spinal cord affecting the vertebral body in a young cat should include inflammatory diseases, such as an empyema, and neoplasias such as lymphoma, often associated with FeLV infection …”

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Vertebral mass in a cat

Meléndez-Lazo

Ros

Fuente

et al. 2017

Veterinary Clinical Pathol

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An 18-month-old neutered male Persian cat was referred to the Hospital Clinic Veterinari of the Universitat Aut onoma de Barcelona (HCV-UAB) for an investigation of a 4-week history of progressive paraparesis. Physical examination was considered normal. Neurologic examination was consistent with a T3-L3 myelopathy. Marked thoracolumbar pain was present. Main differential diagnoses included inflammatory/ infectious disease and neoplasia. Hematology and complete serum biochemistry profiles and an abdominal ultrasonographic examination were unremarkable; feline immunodeficiency virus/feline leukemia virus (FeLV) serologic tests were negative. Thoracic radiographs revealed a radiolucent lesion affecting T11-T13 vertebral bodies. Postmyelographic computed tomography revealed a marked thickening of the pedicle, lamina, and vertebral body of T13 and L1 vertebrae causing spinal cord compression on the left side (Figure 1). A T13-L1 left-side hemilaminectomy was performed in order to decompress the spinal cord and obtain a sample for analysis. Excisional biopsy of the proliferative lesion and intraoperative cytologic imprints were submitted for evaluation ( Figure 2). Figure 1. Transverse computed tomographic image at the level of T13 vertebra in a young cat with progressive paraparesis. Note the marked thickening of the pedicle, lamina, and vertebral body on the left side causing spinal cord compression (arrow).Figure 2. Imprint of an extradural vertebral mass from a young cat with progressive paraparesis. Modified Wright stain.

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Section: Discussionsupporting

confidence: 71%

“…Five cases of vertebral angiomatosis have been previously described in cats with no cases reported in dogs . In all cases, the animals were under 2 years old at presentation.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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What is your diagnosis? Vertebral mass in a cat

Meléndez-Lazo

Ros

Fuente

et al. 2017

Veterinary Clinical Pathol

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“…Vertebral angiomatosis is a rare vascular malformation with few cases reported in the literature. 1 – 5 In dogs several forms of angiomatosis have been reported including cutaneous, 6 , 7 cardiac, 8 meningeal, 9 skeletal 10 and multisystemic forms, 11 whereas in cats it is a little-known disorder. 12 In terms of spinal cord disease in cats or, in general, neurological disorders in feline species, this disease has not previously been considered.…”

Section: Introductionmentioning

confidence: 99%

Feline vertebral angiomatosis: two cases

Frizzi

Ottolini

Spigolon³

et al. 2017

Journal of Feline Medicine and Surgery Open Reports

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Case series summaryTwo cats aged between 1 and 2 years were presented for paraparesis, general discomfort, back pain and urinary retention. Extradural spinal cord compression at the level of T4 and T8 was evident on CT examination and on MRI. Hemilaminectomy and partial corpectomy were performed to achieve spinal cord decompression. Histopathology of the abnormal bone tissue was suggestive of vertebral angiomatosis. After initially worsening, both cats recovered their normal gait and functional urination. Both cats have been followed-up for >1 year, without any recurrence.Relevance and novel informationThis is the first report of vertebral angiomatosis with complete data (CT, MRI, surgical procedures, histopathology and >1 year follow-up) and provides important information about the prognosis of this rare vascular malformation.

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“…A review of the veterinary literature suggests that the vast majority of vascular malformations are of blood vessel origin [5][6][7][8][9][10][11][12][13][14][15]. Only few reports confirm a lymphatic vessel origin of vascular malformations in the skin, intestines, liver and mammary gland [16][17][18][19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Retroperitoneal lymphatic malformation in a dog

Driessen

Cushing²

2020

Acta Vet Scand

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Background: Lymphatic vascular malformations are rare findings in canine patients with six reports available in veterinary literature. Retroperitoneal cystic lymphatic malformations have not been described previously in canine patients and neither has the use of immunohistochemistry to determine their origin, i.e. vascular versus lymphatic. Case presentation: An 8-year-old neutered female Cocker spaniel was referred for pollakiuria, dysuria and a painful abdomen. Computed tomography scanning of the abdomen showed a fluid filled structure adjacent to the urinary bladder. During surgical exploration, a thin walled cystic structure with sero-haemorrhagic fluid was found, extending from the retroperitoneal space into the abdomen. The mass was excised and submitted for histopathology, revealing a cystic mass lined by a fibrovascular capsule within the retroperitoneal/mesenteric adipose tissue. The inner surface of the cyst was lined by a single layer of bland, flattened spindle cells. Intramural blood vessels were well differentiated, with perivascular haemorrhage. On recurrence 11 months later, the mass was excised for the second time and a PleuralPort (Norfolk Animal products) was placed. Fifteen months after initial presentation, progression occurred with haemorrhagic fluid in the cystic space, pleural-and abdominal cavities and the owners opted for euthanasia. Histopathology and positive immunohistochemistry for lymphatic markers lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) and prospero homeobox protein-1 (PROX-1) confirmed a lymphatic vascular origin of the cystic structure. Conclusions: To our experience, a definitive diagnosis of retroperitoneal cystic malformation of lymphatic origin could be done only by combining the clinical presentation, advanced imaging, histopathology and LYVE-1 and PROX-1 immunohistochemistry. This is the first report of a vascular malformation in a dog where immunohistochemistry was used to make a final diagnosis. A lymphatic malformation, even if rare, should be added on the list of the differential diagnosis in a patient with a retroperitoneal cystic structure containing serohaemorrhagic fluid. Results of this case report can aid in diagnosis of future cases, however, further studies on therapy and management are needed to provide additional information about optimal treatment of these patients.

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Spinal cord compression in a cat due to vertebral angiomatosis

Cited by 17 publications

References 9 publications

What is your diagnosis? Vertebral mass in a cat

What is your diagnosis? Vertebral mass in a cat

Feline vertebral angiomatosis: two cases

Retroperitoneal lymphatic malformation in a dog

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