Spinal cord abnormalities in recently diagnosed MS patients

Bot, Joost; Barkhof, Frederik; Polman, Chris H.; Nijeholt, Geert J. Lycklama à; Groot, Vincent de; Bergers, Elisabeth; Adèr, H.J.; Castelijns, Jonas A.

doi:10.1212/wnl.62.2.226

Cited by 274 publications

(242 citation statements)

References 28 publications

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“…Enhancing lesions may be seen on T1-weighted images, representing active MS pathology, though the prevalence of these enhancing lesions is low compared with that in the brain. [35][36][37][38] The findings of Henning et al 23 are in agreement with the metabolite trend found in the present study, except for the mIns peak, but the data from a single patient are insufficient for the purposes of comparison.…”

Section: Discussionsupporting

confidence: 92%

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Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis

Marliani¹,

Clementi²,

Riccioli³

et al. 2009

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Brain proton MR spectroscopy ( 1 H-MR spectroscopy) is a useful technique for evaluating neuronal/axonal damage and demyelization in multiple sclerosis (MS). Because MS disability is frequently related to spinal cord lesions, potential markers for MS stage differentiation and severity would require in vivo quantification of spinal integrity. However, few spectroscopy studies have investigated cervical disease due to technical difficulties. The present study used 3T 1 H-MR spectroscopy to measure the main metabolites in cervical spinal cord plaques of a group in patients with relapsing-remitting MS (RRMS) and compared them with metabolite measurements in healthy volunteers.

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Section: Discussionsupporting

confidence: 92%

“…38 Moreover, the occurrence and the characteristics of spinal cord abnormalities are largely independent of brain lesions. 22,41 Although the sensitivity of spinal cord MR imaging is high, the relation between MR imaging and clinical findings remains poor.…”

Section: Discussionmentioning

confidence: 99%

Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis

Marliani¹,

Clementi²,

Riccioli³

et al. 2009

AJNR Am J Neuroradiol

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“…Spinal MRI is invaluable in identifying the presence of myelitis and allowing for classification into TM and LM. LM is a characteristic finding in NMO/NMOSD and its presence may be used to differentiate from myelitis in classic MS, which rarely extends beyond a single vertebral segment (33). Longitudinal cord involvement has been reported in SLE and SS as well (7,8,14,17,22,23,30,34,35).…”

Section: Discussionmentioning

confidence: 99%

Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis

Kolfenbach

Horner

Ferucci

et al. 2011

Arthritis Care & Research

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“…Nevertheless, asymptomatic cord lesions are found in 30-40% of patients with CIS, and a similar prevalence has been reported in patients with RIS. 19,116,117 Spinal cord MRI is more challenging than brain imaging in patients with MS. The spinal cord is a thin and mobile structure, and these factors make acquisition of high-quality images challenging.…”

Section: Follow-up and Longitudinal Scansmentioning

confidence: 99%

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

et al. 2015

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| The clinical use of MRI in patients with multiple sclerosis (MS) has advanced markedly over the past few years. Technical improvements and continuously emerging data from clinical trials and observational studies have contributed to the enhanced performance of this tool for achieving a prompt diagnosis in patients with MS. The aim of this article is to provide guidelines for the implementation of MRI of the brain and spinal cord in the diagnosis of patients who are suspected of having MS. These guidelines are based on an extensive review of the recent literature, as well as on the personal experience of the members of the MAGNIMS (Magnetic Resonance Imaging in MS) network. We address the indications, timing, coverage, reporting and interpretation of MRI studies in patients with suspected MS. Our recommendations are intended to help radiologists and neurologists standardize and optimize the use of MRI in clinical practice for the diagnosis of MS.

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Spinal cord abnormalities in recently diagnosed MS patients

Abstract: Spinal cord abnormalities are prevalent in patients with early-stage MS, have distinct morphologic characteristics, and help to determine dissemination in space at time of diagnosis.

Cited by 274 publications

References 28 publications

Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis

Quantitative Cervical Spinal Cord 3T Proton MR Spectroscopy in Multiple Sclerosis

Neuromyelitis optica spectrum disorder in patients with connective tissue disease and myelitis

MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis—clinical implementation in the diagnostic process

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