Spinal cerebrospinal fluid volume in healthy elderly individuals

Abstract

The amount of spinal cerebrospinal fluid (CSF) could be of importance for the understanding of CSF dynamics, CSF biomarker analyses as well as for the amount and effect of anaesthesia using intrathecally administered drugs. However, knowledge of spinal CSF volumes is scarce. The main purpose of this article is to present data on spinal CSF volumes. In total, 22 healthy individuals aged between 64 and 76 years underwent MR imaging with a 3D balanced turbo field echo pulse sequence, which provided high contrast between spinal cord, CSF and the extradural surroundings. The entire spinal CSF volume, the cervical, thoracic, and lumbosacral CSF volumes and the spinal cord volume were calculated. The total spinal CSF volume was 81 ± 13 ml (range 52-103 ml). The amount of CSF in the cervical region was 19 ± 4 ml, in the thoracic region 38 ± 8 and in the lumbosacral region 25 ± 7 ml. There was no difference between genders nor was there any correlation with height. The volume of the spinal cord was 20 ± 3 ml. The results present new magnetic resonance imaging-based data on the spinal CSF volume in healthy elderly individuals.

Cerebrospinal fluid volume analysis for hydrocephalus diagnosis and clinical research

“…The reason is not only due to the difference of the methods, but also because of different data and image resolutions. Results on the spinal subarachnoid space confirms the assumption in [6] that the spinal subarachnoid volume assessment is important to discriminate between hydrocephalus patients, i.e. communicating and non-communicating hydrocephalus classes.…”

“…The obtained volumes of the cerebrospinal fluid spaces are summarized in Table 1 where they are matched with previous results from the literature [3,4,5,6,7] for healthy adults, communicating and non-communicating hydrocephalus classes. In Table 1, results vary slightly depending on the articles.…”

“…a specific case of communicating hydrocephalus in [5]. Nevertheless, all of them are restricted to the intracranial region, while it is assumed that the spinal subarachnoid space volume may also provide some information in hydrocephalus analysis [6]. Images reveal most cerebral structures, which do not facilitate segmentation of the fluid itself in a routine way.…”

Cerebrospinal fluid CXCL13 in Lyme neuroborreliosis and asymptomatic HIV infection

“…One subgroup consisted of 18 patients with neurological symptoms such as headache, vertigo and radiculitic pain, where an underlying organic neurological disease had been ruled out and where CSF sampling had been undertaken as part of the investigations. The other subgroup consisted of 21 subjects with no neurological disease or symptoms who had undergone lumbar puncture for CSF sampling as part of a research project unrelated to this study [15]. In accordance with Swedish regulations, informed consent was obtained from all participants prior to inclusion of their CSF and blood samples into the biobank from which the samples then were retrieved.…”

The Connected Steady State Model and the Interdependence of the CSF Proteome and CSF Flow Characteristics

“…For the volume of CSF, we ignore the cranial SAS volume and for the remaining volume of the CSF system we set V CSF = 100 ml (Akdogan et al, 2010; Edsbagge et al, 2011). For reasons of simplification we interpret the CSF system as a tube with constant diameter and further assume that the CSF bulk flow velocity ( V BF ) equals the CSF production rate of 0.3 ml/min along the whole flow path so that $V_{BF}=\frac{0.3\frac{ml}{min}*50cm}{100ml}=0.015\frac{cm}{min}=0.0025\frac{cm}{sec}$.…”