“…While ADH can be detected immunocytochemically in brain (Buhler et al, 1983), activity studies conclude that the dominant class of enzyme in brain is the low-affinity Class III ADH, which is likely to be ineffective at ethanol concentrations found in tissues (Giri et al, 1989). Ethanol metabolized in astrocytes has been reported by others (Fonseca et al, 2001;Jin, Cao, et al, 2021), and studies have shown that astrocyte metabolism also underlies behavioral effects of ethanol (Jin, Cao, et al, 2021;Jin, Cinar, et al, 2021), but we will focus here on its metabolism in neurons. Recent results from Sun and colleagues (Sun et al, 2023) agree with previous findings (Howard et al, 2003), that CYP2E1 is uniquely induced in pyramidal neurons of the prefrontal cortex upon chronic ethanol exposure.…”