Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins

Lantéri-Minet, Michel; Isnardon, P.; Pommery, J. de; Menétrey, D.

doi:10.1016/0306-4522(93)90439-m

Cited by 142 publications

(78 citation statements)

References 74 publications

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“…This approach has been successfully used in the ENS (K irchgessner et al, 1992;Parr and Sharkey, 1994b;Miampamba et al, 1997;Ritter et al, 1997), as it has in the spinal cord (Traub et al, 1992;Lantéri-Minet et al, 1993). In general, I EG expression is a feature of neurons in a high state of activity and is usually observed when intense or prolonged stimulation is applied.…”

Section: Abstract: Neuropeptide Y; Somatostatin; Prevertebral Ganglimentioning

confidence: 99%

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

1999

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Activation of neurons in the inferior mesenteric ganglion (IMG) was assessed using c-fos, JunB, and c-Jun expression in the guinea pig IMG and colonic myenteric plexus during mechanosensory stimulation and acute colitis in normal and capsaicin-treated animals. Intracolonic saline or 2% acetic acid was administered, and mechanosensory stimulation was performed by passage of a small (0.5 cm) balloon either 4 or 24 hr later. Lower doses of capsaicin or vehicle were used to activate primary afferent fibers during balloon passage. c-Jun did not respond to any of the stimuli in the study. c-fos and JunB were absent from the IMG and myenteric plexus of untreated and saline-treated animals. Acetic acid induced acute colitis by 4 hr, which persisted for 24 hr, but c-fos was found only in enteric glia in the myenteric plexus and was absent from the IMG.Balloon passage induced c-fos and JunB in only a small subset of IMG neurons and no myenteric neurons. However, balloon passage induced c-fos and JunB in IMG neurons (notably those containing somatostatin) and the myenteric plexus of acetic acid-treated animals. After capsaicin treatment, c-fos and JunB induction by balloon passage was inhibited in the IMG, but there was enhanced c-fos expression in the myenteric plexus. c-fos and JunB induction by balloon stimulation was also mimicked by acute activation of capsaicin-sensitive nerves. These data suggest that colitis enhances reflex activity of the IMG by a mechanism that involves activation of both primary afferent fibers and the myenteric plexus.

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Section: Abstract: Neuropeptide Y; Somatostatin; Prevertebral Ganglimentioning

confidence: 99%

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

1999

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“…Previous literature supports the role of lamina X in a number of acute and chronic pain conditions including visceral, inflammatory and muscle [1,5,11]. For example, following noxious visceral stimulation the expression of immediate early genes in spinal cord neurons increased, which included lamina X [11].…”

Section: Spinothalamic Neurons and P-nr1mentioning

confidence: 88%

“…For example, following noxious visceral stimulation the expression of immediate early genes in spinal cord neurons increased, which included lamina X [11]. In sheep with footrot, alpha 2 -adrenoreceptor binding increased in lamina I, II, and X [1].…”

Section: Spinothalamic Neurons and P-nr1mentioning

confidence: 99%

Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model

Bement

Sluka

2007

Neuroscience Letters

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Activation of the cAMP pathway is an important mediator of chronic muscle pain. This study examined phosphorylation of the transcription factor cAMP-response-element-binding protein (p-CREB) and the NR1 subunit of the NMDA receptor (p-NR1) in the spinal cord. Bilateral mechanical hyperalgesia of the paw was induced by administering two injections of acidic saline, 5 d apart, into the gastrocnemius muscle of male Sprague Dawley rats. The proportion of spinothalamic neurons that expressed p-NR1 or p-CREB did not change in the dorsal horn 24 hours after the second intramuscular acid injection compared with animals that received pH 7.2 injections. This lack of change in spinothalamic neurons in the dorsal horn may be due to increases in individual spinothalamic neurons or increases in non-spinothalamic neurons. There was an increase in the proportion of spinothalamic neurons expressing p-NR1 in lamina X. These findings suggest that there are region-specific changes in spinothalamic neurons that express p-NR1 and lamina X may play an important role in the modulation of chronic muscle pain.

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“…Indeed, inflammation is well known to sensitise afferent fibers to pain (Bueno and Fioramonti, 1999) and IBS symptoms have been observed after infectious diarrhoea (Gwee et al, 1996) and in patients with inflammatory bowel diseases (IBD) in remission (Isgard et al, 1983). Intraperitoneal (ip) injection of acetic acid (AA) is a well known noxious chemical somato-visceral stimulus in rats (Koster et al, 1959;Menetrey et al, 1989;Hammond et al, 1992;Lanteri-Minet et al, 1993) as evidenced by the presence of abdominal contractions (Koster et al, 1959;Pairet et al, 1989;Rivière et al, 1993Rivière et al, , 1994.…”

Section: Introductionmentioning

confidence: 99%

Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat

Sinniger

Mouchet²,

Bonaz

2005

Life Sciences

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To cite this version:Valérie Sinniger, Patrick Mouchet, Bruno Bonaz. Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.. Life Sciences, Elsevier, 2005, 77 (23) EFFECT OF NOR-TRIMEBUTINE ON NEURONAL ACTIVATION INDUCED BY A NOXIOUS STIMULUS OR AN ACUTE COLONIC INFLAMMATION IN THE RATValérie Sinniger(1,2), Patrick Mouchet (1), and Bruno Bonaz (1,2) ABSTRACTNor-trimebutine is the main metabolite of trimebutine which is used in the treatment of patients with irritable bowel syndrome. Nor-trimebutine has a blocking activity on sodium channel and a potent local anaesthetic effect. These properties were used to investigate the effect of nortrimebutine on spinal neuronal activation induced by models of noxious somato-visceral stimulus and acute colonic inflammation. Nor-trimebutine was administered subcutaneously in rats 30 min

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Spinal and hindbrain structures involved in visceroception and visceronociception as revealed by the expression of Fos, Jun and Krox-24 proteins

Cited by 142 publications

References 74 publications

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

Immediate-Early Gene Expression in the Inferior Mesenteric Ganglion and Colonic Myenteric Plexus of the Guinea Pig

Co-localization of p-CREB and p-NR1 in spinothalamic neurons in a chronic muscle pain model

Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat

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