Spinal and Cerebral Integration of Noxious Inputs in Left-handed Individuals

Northon, Stéphane; Deldar, Zoha; Piché, Mathieu

doi:10.1007/s10548-021-00864-y

Cited by 5 publications

(6 citation statements)

References 136 publications

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“…The results show that bilateral stimulation leads to a greater increase in pain perception when the hands are in the near compared with the far position, consistent with the effect on the P2 and previous studies (Lautenbacher et al, 2007;Quevedo & Coghill, 2007). The results may also explain why bilateral noxious stimuli increased pain when applied on both feet (close from each other), but not on both hands (70 cm apart) or on a foot and a hand (Northon et al, 2019(Northon et al, , 2021a(Northon et al, , 2021bRustamov et al, 2019). Although this should be examined in future studies, it could be speculated that this effect is related to perceptual fusion and to the overlap in the limb-centered peripersonal space of each limb .…”

Section: Effects Of Limb Position On the Interaction Of Bilateral Noxious Inputssupporting

confidence: 90%

“…Of the 27 participants, 25 were right-handed, one was ambidextrous, and one was left-handed. These two non-right-handed participants were included in the study because it was shown that pain as well as cerebral responses and integration are comparable between right-and lefthanded individuals (Northon et al, 2021b).…”

Section: Participantsmentioning

confidence: 99%

“…Consistent with these findings, several participants of the present study (30%) showed decreased N2 and P2 amplitude or no change, for bilateral compared with unilateral stimulation, although the group effect showed significantly increased N2 and P2 amplitude. Notwithstanding, the most common effect of bilateral compared with unilateral noxious stimulation (electrical or laser) on event-related potentials is an increase of the N2 and P2 (laser) as well as the N100 (electrical), but not the P260 (electrical) (Northon et al, 2019(Northon et al, , 2021a(Northon et al, , 2021bRustamov et al, 2019). Considering the view that event-related potentials are not specific to pain but mostly reflect a multimodal salience detection system (Iannetti et al, 2008), the results suggest that the integration of bilateral noxious inputs may serve to generate a F I G U R E 4 Lateralized event-related potentials.…”

Section: Increased Pain-related Brain Responses For Bilateral Stimulationmentioning

confidence: 99%

“…To provide a better estimate of potential bodily threat as well as defensive behaviors that are adapted to the context and the environment, the cerebral cortex integrates sensory inputs from different sources and modalities (Tabor et al, 2017). It has been shown that bilateral noxious inputs interact in the brain, leading to increased or decreased vertex evoked potential amplitude (Northon et al, 2019(Northon et al, , 2021a(Northon et al, , 2021bRustamov et al, 2019). However, the factors that determine or influence this modulation remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…This may modulate the integration of bilateral noxious inputs in the brain to generate a better representation of the physical threat, as the distance between hands affects the likelihood that both stimuli originate from a common source. This may partly explain why bilateral noxious stimuli applied on the feet (near from each other), but not on the hands (inter-limb distance of 70 cm) increase pain and pain-related brain activity compared with unilateral stimulation (Northon et al, 2019(Northon et al, , 2021a(Northon et al, , 2021bRustamov et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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Effects of spatial attention and limb position on the cortical interaction of bilateral noxious inputs

2021

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Bilateral noxious inputs interact in the brain to provide a better representation of physical threat. In the present study, we investigated the effects of spatial attention and limb position on this interaction. Painful laser stimuli were applied randomly on the right hand or on both hands, while varying spatial attention (focal or overall) and limb position (hands near or far from each other). Pain perception and laser-evoked potentials (N1, N2, P2) were compared between conditions in 27 healthy volunteers. Compared with unilateral stimulation, bilateral stimulation increased pain (p = .004), the N2 (p = .0015) and P2 (p < .001) amplitude. The effects on pain and the P2 were greater when hands were in the near compared with the far position (p < .05). The effect on pain was also greater for overall compared with focal pain rating (p = .003). In addition, the N1 amplitude was greater for bilateral stimulation when hands were in the far compared with the near position (p = .01). These results show that increased brain responses and pain for bilateral compared with unilateral noxious stimulation are modulated differentially by spatial attention and limb position. This suggests that the integration of noxious inputs occurs through partially independent pain-related processes, that it is modulated by limb position, and that it is partially independent of pain perception. We propose that this is necessary to produce coordinated, flexible and adapted defensive responses.

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