“…In rodents, the majority are located in dorsal root ganglia (DRG) in spinal levels lumbar 6 and sacral 1 (L6-S1; Dang et al, 2005;Xu and Gebhart, 2008;Forrest et al, 2013); we refer to these as "sacral" DRG as they are functionally equivalent to neurons found exclusively in sacral levels in humans. Pelvic visceral sensory neurons comprise two major classes, those with lightly myelinated (A-d ) or unmyelinated (C) axons (Dang et al, 2005;Franken et al, 2014;de Groat et al, 2015;Gebhart and Bielefeldt, 2016;Brierley et al, 2018). Many express transient receptor potential (TRP) channels that transduce noxious stimuli, including Trpv1, Trpa1, and Trpm8 (Skryma et al, 2011;Franken et al, 2014;Merrill et al, 2016), which are also expressed in subpopulations of somatic nociceptors (Patapoutian et al, 2009;Julius, 2013).…”