Spinal 5-HT5A receptors mediate 5-HT-induced antinociception in several pain models in rats

Muñoz-Islas, Enriqueta; Vidal‐Cantú, Guadalupe C.; Bravo‐Hernández, Mariana; Cervantes-Durán, Claudia; Quiñonez-Bastidas, Geovanna Nallely; Pineda-Farías, Jorge Baruch; Barragán-Iglesias, Paulino; Granados‐Soto, Vinicio

doi:10.1016/j.pbb.2014.02.001

Cited by 41 publications

(23 citation statements)

References 56 publications

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“…Whilst 5-CT has highest affinity with the rat 5-HT5AR it also agonizes 5-HT1R and 5-HT7R families (Nelson, 2004). However, the lack of overlap in activity of 5-CT and the specific 5-HT5AR antagonist, SB699551 (Muñoz-Islas et al, 2014), coupled with the gene expression differences suggests that it is the 5-HT5AR that is responsible for the differences observed in 5-HT-mediated inhibition of food consumption. The lack of a demonstrable difference between the groups in 5-HT2CR action is consistent with the suggestion that it is the 5-HT5AR that is the main subtype affected in the offspring of dams fed a low protein diet during the postnatal period.…”

Section: Discussionmentioning

confidence: 99%

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

et al. 2020

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Background: Though it is well established that neonatal nutrition plays a major role in lifelong offspring health, the mechanisms underpinning this have not been well defined. Early postnatal accelerated growth resulting from maternal nutritional status is associated with increased appetite and body weight. Likewise, slow growth correlates with decreased appetite and body weight. Food consumption and food-seeking behaviour are directly modulated by central serotonergic (5-hydroxytryptamine, 5-HT) pathways. This study examined the effect of a rat maternal postnatal low protein (PLP) diet on 5-HT receptor mediated food intake in offspring. Methods: Microarray analyses, in situ hybridization or laser capture microdissection of the ARC followed by RT-PCR were used to identify genes up-or down-regulated in the arcuate nucleus of the hypothalamus (ARC) of 3-month-old male PLP rats. Third ventricle cannulation was used to identify altered sensitivity to serotonin receptor agonists and antagonists with respect to food intake. Results: Male PLP offspring consumed less food and had lower growth rates up to 3 months of age compared to Control offspring from dams fed a normal diet. 97 genes were upregulated (including the 5-HT5A receptor (5-HT5AR) and 149 downregulated genes in PLP rats compared to Controls. The former obesity medication fenfluramine and the 5-HT receptor agonist 5-Carboxamidotryptamine (5-CT) significantly suppressed food intake in both groups, but the PLP offspring were more sensitive to d-fenfluramine and 5-CT compared to Controls. The effect of 5-CT was antagonized by the 5-HT5AR antagonist SB699551. 5-CT also reduced NPY-induced hyperphagia in both Control and PLP rats but was more effective in PLP offspring. Conclusions: Postnatal low protein programming of growth in rats enhances the central effects of serotonin on appetite by increasing hypothalamic 5-HT5AR expression and sensitivity. These 4 findings provide insight into the possible mechanisms through which a maternal low protein diet during lactation programs reduced growth and appetite in offspring.

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Section: Discussionmentioning

confidence: 99%

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

et al. 2020

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“…In the cerebral cortex of rodents, 5-HT5 receptor stimulation induces an inward rectifying outward current that is suppressed by blockers of Kir3 channels (Goodfellow et al, 2012). The 5-HT5 receptor has been involved in pain (Munoz-Islas et al, 2014), cognitive deficits in a rat model of schizophrenia (Avila-Rojas et al, 2015;Nikiforuk et al, 2016) and in the acoustic startle circuits (Curtin et al, 2013).…”

Section: -Ht5a Receptormentioning

confidence: 99%

Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes

Marin

Bécamel

Chaumont‐Dubel

et al. 2020

Handbook of Behavioral Neuroscience

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HAL is a multidisciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…93 Furthermore, an animal pain model suggests that spinal neuron 5-HT 5A receptors are involve in 5-HT-induced analgesia in rats. 94 …”

Section: Serotonin and Painmentioning

confidence: 99%

The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance

Özdemir

2017

Int J Basic Clin Pharmacol

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Continuous treatment with opioid analgesics, such as morphine, leads to the development of ant nociceptive tolerance in patients. Although a lot of information about antinociceptive, the pathophysiological mechanisms of tolerance to opioid analgesia are not yet completely understood. Proposed mechanisms for opioid analgesic tolerance comprise down-regulation of opioid receptors, reduction of sensitivity G-proteins, altered intracellular signalling pathway including nitric oxide, adenyl cyclase, and protein kinase C. Numerous physiological and behavioural studies have shown an interaction of the serotonergic system and opioid antinociception. The serotonin (5-HT) receptor system is a necessary component of the spinal and midbrain pain modulation circuit mediating opioid analgesia. Various types of serotonin receptors demonstrate different effects on morphine analgesia. Systemic administration of opioids rise 5-HT levels in the spinal cord dorsal horn and contribute to opioid analgesia in the normal state but reduce that in neuropathic pain via spinal 5-HT3 receptors. Spinal and supraspinal serotonergic neurons may also play a pathophysiological role in the development of morphine analgesic tolerance. Serotonin receptor subtypes show different effects on opioid tolerance. This review paper focus on the current understanding of the role of serotonin receptor systems in opioid analgesia and tolerance.

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Spinal 5-HT5A receptors mediate 5-HT-induced antinociception in several pain models in rats

Cited by 41 publications

References 56 publications

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

Developmental programming of appetite and growth in male rats increases hypothalamic serotonin (5-HT)5A receptor expression and sensitivity

Classification and signaling characteristics of 5-HT receptors: toward the concept of 5-HT receptosomes

The pathophysiological role of serotonin receptor systems in opioid analgesia and tolerance

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