Spina bifida and parental occupation in a Swedish register-based study

Blatter, B.M.; Roeleveld, Nel

doi:10.5271/sjweh.164

Cited by 19 publications

(8 citation statements)

References 23 publications

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“…The general trend refers merely to occupational rather than to environmental exposure that was not often assessed (Table 4). Main risk factors include parental occupational exposure to pesticides, with agricultural workers/people living in farms been significantly exposed (Blatter and Roeleveld, 1996; Blatter et al, 2000; Fear et al, 2007; Lacasana et al, 2006; Makelarski et al, 2014). The significance of maternal or paternal environmental/occupational exposure was debated.…”

Section: Neural Tube Defectsmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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Human pesticide exposure can occur both occupationally and environmentally during manufacture and after the application of indoor and outdoor pesticides, as well as through consumption via residues in food and water. There is evidence from experimental studies that numerous pesticides, either in isolation or in combination, act as endocrine disruptors, neurodevelopmental toxicants, immunotoxicants, and carcinogens. We reviewed the international literature on this subject for the years between 1990 and 2017. The studies were considered in this review through MEDLINE and WHO resources. Out of the n = 1817 studies identified, n = 94 were reviewed because they fulfilled criteria of validity and addressed associations of interest. Epidemiological studies have provided limited evidence linking pre- and post-natal exposure to pesticides with cancers in childhood, neurological deficits, fetal death, intrauterine growth restriction, preterm birth, and congenital abnormalities (CAs). In this review, the potential association between pesticide exposure and the appearance of some human CAs (including among others musculoskeletal abnormalities; neural tube defects; urogenital and cardiovascular abnormalities) was investigated. A trend towards a positive association between environmental or occupational exposure to some pesticides and some CAs was detected, but this association remains to be substantiated. Main limitations of the review include inadequate exposure assessment and limited sample size. Adequately powered studies with precise exposure assessments such as biomonitoring, are warranted to clarify with certainty the potential association between pesticide exposure and human CAs.

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Section: Neural Tube Defectsmentioning

confidence: 99%

Association of pesticide exposure with human congenital abnormalities

Kalliora

Mamoulakis

Vasilopoulos

et al. 2018

Toxicology and Applied Pharmacology

102

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“…Studies of parental occupation and the occurrence of NTDs (42–46) found increased odds ratios associated with both paternal and maternal occupations, including welding, transport, painting (paternal), cleaning, healthcare occupations (nursing, dentistry), and agriculture.…”

Section: Maternal Factors Affecting Ntd Prevalencementioning

confidence: 99%

Epidemiology of Neural Tube Defects

2003

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Summary: Neural tube defects (NTDs)-malformations secondary to abnormal neural tube closure between the third and fourth weeks of gestational age-have a complex and imperfectly understood etiology in which both genetic and environmental factors appear to be involved. A number of specific chromosomal or single-gene disorders, presumably not affected by environmental influences, are associated with the development of NTDs, but such syndromal cases account for a small proportion of NTDs in live-born infants. Analysis of recurrence patterns within families and of twin-concordance data provides evidence of a genetic influence in nonsyndromal cases, but factors such as socioeconomic status and geographic area (independent of race or ethnicity) are also associated with variations in the incidence of NTDs. The prevalence at birth of both anencephaly and spina bifida has decreased, but the advent of antenatal diagnosis and elective termination of affected pregnancies has undermined the reliability of birth prevalence rate as an estimate of incidence. Some occupational and other exposures, including maternal use of antiepileptic drugs (AEDs), are associated with increased risk for NTDs. Among women who have had an NTD-affected pregnancy, recurrence risk is markedly higher than the risk for a first NTD-affected pregnancy in the general population. There is strong evidence, overall, for a protective effect of adequate folate consumption. In some high-risk groups, however, such as women taking AEDs, folate supplementation has not been proven to reduce NTD risk.

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“…Because exposure usually involves more than one chemical class or agent and may occur under a wide variety of circumstances, human epidemiologic studies must be interpreted with care. However, if the above results [Taskinen et al, 1989;Brender and Suarez, 1990;Schnitzer et al, 1995;Blatter and Roeleveld, 1996; Blatter et al, 1997;Irgens et al, 2000] are valid, then preventive measures should be taken to avoid exposures to organic solvents, by both males as well as females.We present a meta-analysis to summarize the impact of paternal exposure to organic solvents with respect to several important pregnancy outcomes including SA and MMs. …”

mentioning

confidence: 97%

“…These compounds have been shown to increase the risk of MMs significantly (ORs ¼ 1.64, CI 95% : 1.16-2.30, N ¼ 7,036) [McMartin et al, 1998]. Several studies have indicated that paternal exposure to organic solvents may be associated with an increased risk of ß 2004 Wiley-Liss, Inc. [Taskinen et al, 1989;Brender and Suarez, 1990;Blatter and Roeleveld, 1996; Blatter et al, 1997;Irgens et al, 2000]. Results of individual studies differ considerably [Daniell and Vaughan, 1988;Taskinen et al, 1989;Lindbohm et al, 1991] and the actual risk remains uncertain.…”

mentioning

confidence: 99%

Paternal organic solvent exposure and adverse pregnancy outcomes: A meta-analysis

et al. 2004

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Background Organic solvents are widely used, but conflicting reports exist concerning paternal exposure and adverse pregnancy outcomes. We conducted a meta-analysis to assess the risks of spontaneous abortions (SAs) and major malformations (MMs) after paternal exposure to organic solvents. Methods Medline, Toxline, Reprotox, and Embase from 1966 to 2003 were searched. Two independent reviewers searched for cohort and case-control studies in any language on adult human males exposed chronically to any organic solvent. Two non-blinded independent extractors used a standardized form for data extraction; disagreements were resolved through consensus discussion. Results Forty-seven studies were identified; 32 exclusions left 14 useable studies. Overall random effects odds ratios and 95% confidence intervals (CI 95% ) were 1. KEY WORDS: paternal exposure; organic solvent; adverse pregnancy outcome; spontaneous abortion; major malformations; meta-analysis INTRODUCTIONOrganic solvents are volatile liquids that belong to a structurally diverse group of chemicals having a low molecular weight and dissolve other organic substances such as lipids and high molecular weight compounds. Presently, they are being widely used in both the work and home environment. Usually, incidental exposure can take place around the house, while extensive exposure mostly occurs in the workplace. The use of organic solvents is widespread; they are utilized in a variety of occupations such as painting, dry-cleaning, printing, and various jobs within the chemical industry. Thus, many employees are exposed extensively to organic solvents.Substantial research has been done into the relationship between maternal exposure to organic solvents and spontaneous abortion (SA) or other adverse pregnancy outcomes such as major malformations (MMs). These compounds have been shown to increase the risk of MMs significantly (ORs ¼ 1.64, CI 95% : 1.16-2.30, N ¼ 7,036) [McMartin et al., 1998].Several studies have indicated that paternal exposure to organic solvents may be associated with an increased risk of ß 2004 Wiley-Liss, Inc. [Taskinen et al., 1989;Brender and Suarez, 1990;Blatter and Roeleveld, 1996; Blatter et al., 1997;Irgens et al., 2000]. Results of individual studies differ considerably [Daniell and Vaughan, 1988;Taskinen et al., 1989;Lindbohm et al., 1991] and the actual risk remains uncertain.One possible mechanism associated with adverse pregnancy outcomes due to paternal exposure to organic solvents is a direct effect on sperm DNA, producing mutations or chromosomal abnormalities. Alternately, there could be indirect effects by transmission of agents to the mother via the seminal fluid, and maternal exposure to agents brought home by the father [Olshan et al., 1991].Organic solvents are comprised of many different chemical compounds or classes of compounds. Because exposure usually involves more than one chemical class or agent and may occur under a wide variety of circumstances, human epidemiologic studies must be interpreted with care. However, ...

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Spina bifida and parental occupation in a Swedish register-based study

Cited by 19 publications

References 23 publications

Association of pesticide exposure with human congenital abnormalities

Association of pesticide exposure with human congenital abnormalities

Epidemiology of Neural Tube Defects

Paternal organic solvent exposure and adverse pregnancy outcomes: A meta-analysis

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