Spin chemistry

Hore, P. J.; Ivanov, Konstantin L.; Wasielewski, Michael R.

doi:10.1063/5.0006547

Cited by 44 publications

(50 citation statements)

References 73 publications

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“…The above-described Radical Pair Mechanism (RPM) is one of the most well-established models in quantum biology; it could give a promising explanation for how migratory birds can navigate by means of Earth’s magnetic field 32 , 33 . The application of RPM has begun to gain momentum in numerous fields of research 34 . Most recently, Smith et al, inspired by the the RPM explanation of avian magnetoreception, have shown that the RPM could play a role in xenon-induced anesthesia, which exhibits isotopic dependence 35 .…”

Section: Introductionmentioning

confidence: 99%

Entangled radicals may explain lithium effects on hyperactivity

Zadeh-Haghighi

Simon

2021

Sci Rep

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It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium’s effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain’s cognitive processes.

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Section: Introductionmentioning

confidence: 99%

Entangled radicals may explain lithium effects on hyperactivity

Zadeh-Haghighi

Simon

2021

Sci Rep

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“…The above-described Radical Pair Mechanism (RPM) is one of the most well-established models in quantum biology; it could give a promising explanation for how migratory birds can navigate by means of Earth's magnetic field 32,33 . The application of RPM has begun to gain momentum in numerous fields of research 34 . Most recently, Smith et al, inspired by the the RPM explanation of avian magnetoreception, have shown that the RPM could play a role in xenon-induced anesthesia, which exhibits isotopic dependence 35 .…”

Section: Introductionmentioning

confidence: 99%

Entangled radicals may explain lithium effects on hyperactivity

Zadeh-Haghighi

Simon

2021

Preprint

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It is known that bipolar disorder and its lithium treatment involve the modulation of oxidative stress. Moreover, it has been observed that lithium's effects are isotope-dependent. Based on these findings, here we propose that lithium exerts its effects by influencing the recombination dynamics of a naturally occurring radical pair involving oxygen. We develop a simple model inspired by the radical-pair mechanism in cryptochrome in the context of avian magnetoreception and xenon-induced anesthesia. Our model reproduces the observed isotopic dependence in the lithium treatment of hyperactivity in rats. It predicts a magnetic-field dependence of the effectiveness of lithium, which provides one potential experimental test of our hypothesis. Our findings show that Nature might harness quantum entanglement for the brain's cognitive processes.

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“…Radical pairs play an pivotal role in a variety of biological functions, including, for instance, enzyme catalysis and associated cell metabolic process enabled by coenzyme B 12 which has displayed interesting magnetic effects [78]. Our work therefore provides an important framework to understand the advantages that quantum coherence may provide in a variety of biological and chemical process involving radical pair dynamics [79].…”

Section: Discussionmentioning

confidence: 88%

Basis-independent system-environment coherence is necessary to detect magnetic field direction in an avian-inspired quantum magnetic sensor

Le,

Olaya-Castro

2020

Preprint

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Advancing our understanding of non-trivial quantum effects in biomolecular complexes operating in physiological conditions requires the precise characterisation of the non-classicalities that may be present in such systems as well as asserting whether such features are required for robust function.Here we consider an avian-inspired quantum magnetic sensor composed of two radicals with a third "scavenger" radical under the influence of a collisional environment that allows to capture a variety of decoherence processes. We show that basis-independent coherence, in which the initial systemenvironment state is non-maximally mixed, is necessary for optimal performance of the quantum magnetic sensor, and appears to be sufficient in particular situations. We discuss how such nonmaximally mixed initial states may be common for a variety of biomolecular scenarios. Our results therefore suggest that a small degree of coherence-regardless of basis-is likely to be a quantum resource for biomolecular systems operating at the interface between the quantum and classical domains.

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Spin chemistry

Cited by 44 publications

References 73 publications

Entangled radicals may explain lithium effects on hyperactivity

Entangled radicals may explain lithium effects on hyperactivity

Entangled radicals may explain lithium effects on hyperactivity

Basis-independent system-environment coherence is necessary to detect magnetic field direction in an avian-inspired quantum magnetic sensor

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