Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition

Nie, Chuanxiong; Stadtmüller, Marlena; Yang, Hua; Xia, Yi; Wolff, Thorsten; Cheng, Chong; Haag, Rainer

doi:10.1021/acs.nanolett.0c01723

Cited by 51 publications

(47 citation statements)

References 44 publications

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“…Two concepts must be carefully designed and integrated to construct the bionic nanosystem with LCK action. i) Developing the spiky nanostructures to enhance the interactions between nanomaterials and pathogenic bacteria; [ 11,12 ] meanwhile, the spiky structure must be mesoporous to load and release bactericidal substances. [ 13 ] ii) Second, developing an efficient and robust bactericidal system without using any antibiotics.…”

Section: Figurementioning

confidence: 99%

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

et al. 2021

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Nature has created an efficient sterilization model, i.e., the in situ bacterial capture and killing process via bacteriophages. The bacteriophage is a virus with a unique spiny tail foot; in general, it can capture bacteria and subsequently release nucleic acid to achieve replication and kill bacteria. We define this two-steps process as the localized "capture and killing" (LCK) action. Therefore, it is believed that this bioinspired LCK action may provide massive possibilities for developing efficient disinfection strategies as alternatives to conventional clinical antibiotic treatments. Two concepts must be carefully designed and integrated to construct the bionic nanosystem with LCK action. i) Developing the spiky nanostructures to enhance the interactions between nanomaterials and pathogenic bacteria; [11,12] meanwhile, the spiky structure must be mesoporous to load and release bactericidal substances. [13] ii) Second, developing an efficient and robust bactericidal system without using any antibiotics. [14-18] Compared to many traditional bactericidal molecules, antibacterial strategies based on reactive oxygen species (ROS) have been intensively studied. [19] Due to its short life cycle, ROS can only cause irreversible damage to substances immediately around it. This spatially confined activity helps to develop targeted applications as well as guarantee excellent biocompatibility during usage. [20,21] Moreover, the molecular weight of ROS is very Besides the pandemic caused by the coronavirus outbreak, many other pathogenic microbes also pose a devastating threat to human health, for instance, pathogenic bacteria. Due to the lack of broad-spectrum antibiotics, it is urgent to develop nonantibiotic strategies to fight bacteria. Herein, inspired by the localized "capture and killing" action of bacteriophages, a virus-like peroxidase-mimic (V-POD-M) is synthesized for efficient bacterial capture (mesoporous spiky structures) and synergistic catalytic sterilization (metalorganic-framework-derived catalytic core). Experimental and theoretical calculations show that the active compound, MoO 3 , can serve as a peroxocomplex-intermediate to reduce the free energy for catalyzing H 2 O 2 , which mainly benefits the generation of •OH radicals. The unique virus-like spikes endow the V-POD-M with fast bacterial capture and killing abilities (nearly 100% at 16 µg mL-1). Furthermore, the in vivo experiments show that V-POD-M possesses similar disinfection treatment and wound skin recovery efficiencies to vancomycin. It is suggested that this inexpensive, durable, and highly reactive oxygen species (ROS) catalytic active V-POD-M provides a promising broad-spectrum therapy for nonantibiotic disinfection. The global pandemic caused by the outbreak of coronavirus has aroused tremendous attention across broad scientific communities. Besides the coronavirus pandemic, many other pathogenic microbes also pose a devastating threat to human health. For instance, pathogenic bacteria have infected millions of people and caused almos...

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Section: Figurementioning

confidence: 99%

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

et al. 2021

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“…Based on the complex topology of spherical influenza virus particles, including the presence of protruding glycoproteins, Nie et al fabricated spiky silica nanoparticles that exhibited improved adhesion to the virus particles, as compared to smooth silica nanoparticles (Figure 2e). [39] The spike dimensions were optimized so that the nanoparticle spikes could fit well in between the glycoprotein protrusions ( Figure 2f,g). Notably, however, the spiky silica nanoparticles had low aqueous dispersibility, so they were initially coated with polyethylene glycol (PEG) but did not inhibit influenza virus infection of canine kidney-derived MDCK-II cells in vitro.…”

Section: Pristine Nanomaterialsmentioning

confidence: 99%

“…Reproduced with permission. [39] Copyright 2020, American Chemical Society. such, stopping these virus-cell binding interactions via competitive inhibitors can prevent infection and various classes of sulfonated polysaccharides have been explored, including heparin [43] and heparin-like molecules [44] along with metal complexes of sulfonated molecules, and exhibit antiviral activity in vitro.…”

Section: Sulfonated Nanoparticlesmentioning

confidence: 99%

Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines

Jackman

Yoon

Ouyang

et al. 2020

Adv Funct Materials

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The ongoing coronavirus disease 2019 (COVID-19) pandemic highlights the importance of developing effective virus targeting strategies to treat and prevent viral infections. Since virus particles are nanoscale entities, nanomaterial design strategies are ideally suited to create advanced materials that can interact with and mimic virus particles. In this progress report, the latest advances in biomimetic nanomaterials are critically discussed for combating viral infections, including in the areas of nanomaterial-enhanced viral replication inhibitors, biomimetic virus particle capture schemes, and nanoparticle vaccines. Particular focus is placed on nanomaterial design concepts and material innovations that can be readily developed to thwart future viral threats. Pertinent nanomaterial examples from the COVID-19 situation are also covered along with discussion of human clinical trial efforts underway that might lead to next-generation antiviral therapies and vaccines.

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“…Nie et al [ 118 ] developed heteromultivalent inhibitors of IAV engaging both HA and neuraminidase (NA). In another very recent study, the authors developed ‘spiky’ nanostructures with a topology that matched that of IAV [ 119 ]. They could show that spiky nanoparticles bind better to the IAV virion than smooth nanoparticles.…”

Section: Nanomedicine: Bio-mimicking Particlesmentioning

confidence: 99%

No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19

Jones

Monopoli

Campagnolo

et al. 2020

Nanomedicine (Lond.)

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There is an urgent need for safe and effective approaches to combat COVID-19. Here, we asked whether lessons learned from nanotoxicology and nanomedicine could shed light on the current pandemic. SARS-CoV-2, the causative agent, may trigger a mild, self-limiting disease with respiratory symptoms, but patients may also succumb to a life-threatening systemic disease. The host response to the virus is equally complex and studies are now beginning to unravel the immunological correlates of COVID-19. Nanotechnology can be applied for the delivery of antiviral drugs or other repurposed drugs. Moreover, recent work has shown that synthetic nanoparticles wrapped with host-derived cellular membranes may prevent virus infection. We posit that nanoparticles decorated with ACE2, the receptor for SARS-CoV-2, could be exploited as decoys to intercept the virus before it infects cells in the respiratory tract. However, close attention should be paid to biocompatibility before such nano-decoys are deployed in the clinic.

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Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition

Cited by 51 publications

References 44 publications

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

Bioinspired Spiky Peroxidase‐Mimics for Localized Bacterial Capture and Synergistic Catalytic Sterilization

Biomimetic Nanomaterial Strategies for Virus Targeting: Antiviral Therapies and Vaccines

No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19

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