Spike initiation in a hippocampal interneuron model

Saraga, Fernanda; Skinner, Frances K.

doi:10.1016/s0925-2312(02)00835-4

Cited by 1 publication

(1 citation statement)

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“…A tonic input into a distal dendrite will always evoke a spike that is first seen in the soma and which then back‐propagates into the dendritic tree. A tonic input into the soma can produce either an antidromic (back‐propagating) spike that originates in the soma or an orthodromic (forward‐propagating) spike that originates in the distal dendrite depending on the amount of current injected (Saraga & Skinner, 2003). We tested our ‘spike initiation due to proximal or distal synaptic input’ results in a Case 2 model that contained an axon with 1.5 times the somatic sodium and potassium channels.…”

Section: Resultsmentioning

confidence: 99%

Active dendrites and spike propagation in multicompartment models of oriens‐lacunosum/moleculare hippocampal interneurons

Saraga

Zhang

et al. 2003

The Journal of Physiology

107

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It is well known that interneurons are heterogeneous in their morphologies, biophysical properties, pharmacological sensitivities and electrophysiological responses, but it is unknown how best to understand this diversity. Given their critical roles in shaping brain output, it is important to try to understand the functionality of their computational characteristics. To do this, we focus on specific interneuron subtypes. In particular, it has recently been shown that long‐term potentiation is induced specifically on oriens‐lacunosum/moleculare (O‐LM) interneurons in hippocampus CA1 and that the same cells contain the highest density of dendritic sodium and potassium conductances measured to date. We have created multi‐compartment models of an O‐LM hippocampal interneuron using passive properties, channel kinetics, densities and distributions specific to this cell type, and explored its signalling characteristics. We found that spike initiation depends on both location and amount of input, as well as the intrinsic properties of the interneuron. Distal synaptic input always produces strong back‐propagating spikes whereas proximal input could produce both forward‐ and back‐propagating spikes depending on the input strength. We speculate that the highly active dendrites of these interneurons endow them with a specialized function within the hippocampal circuitry by allowing them to regulate direct and indirect signalling pathways within the hippocampus.

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Section: Resultsmentioning

confidence: 99%