Spike Activity and Genome Instability in Neurons of the Amygdaloid Complex in Rats of Selected Strains with Contrasting Nervous System Arousability in Normal Conditions and Stress

Sivachenko, Ivan B.; Pavlova, M. B.; Vaido, A. I.; Shiryaeva, N. V.; Panteleev, S. S.; Dyuzhikova, N. A.; Lyubashina, O. A.

doi:10.1007/s11055-021-01115-0

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…However, such selection can modulate the excitability of the central nervous system. It is shown that spontaneous and induced neuronal activity in the amygdala of LT and HT rats differs just like the threshold value of peripheral n. tibialis (Sivachenko et al, 2021).…”

Section: Resultsmentioning

confidence: 96%

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Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

Shcherbinina

Vaido

Khlebaeva

et al. 2022

BioComm

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Changes of genome stability in hippocampal cells of male rats with hereditary high and low thresholds of nervus tibialis response to electric stimuli (HT and LT strains, respectively) were studied in unstressed and stressed animals. HT and LT originated from Wistar strain, males of which were also used as a control. The comet assay was used after prolonged emotional painful stressor action. There were no interstrain differences in the spontaneous percentage of DNA in comet tails (tDNA). However, the prolonged emotional pain stressor induced genome instability differently in animals of different strains. The highest level of DNA damage in hippocampal cells was shown in highly sensitive animals of LT strain. Males of Wistar strain had intermediate levels of tDNA, while HT animals had the lowest stress reactivity.

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Section: Resultsmentioning

confidence: 96%

“…The latter may be involved in the initiation and maintenance of pathological states. Moreover, this may or may not be related to inherited features of the animal's nervous system (Pavlova et al, 2020;Sivachenko et al, 2021).…”

Section: Resultsmentioning

confidence: 99%

Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

Shcherbinina

Vaido

Khlebaeva

et al. 2022

BioComm

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“…In this case, it can be hypothesized that a constitutively higher TNF level in the cortex and its lower level in the amygdala in LT animals as compared to HT animals contribute to a higher excitability of the former. Experimental verification of this hypothesis appears promising due to the fact that a higher background spiking activity of amygdala neurons has previously been found in highly excitable LT rats compared to the HT strain [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Long-Term Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

Shalaginova

Tuchina

Turkin

et al. 2023

J Evol Biochem Phys

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Stress plays an important role in the pathogenesis of anxiety and depressive disorders. Neuroinflammation is considered as one of the mechanisms by which stress alters the molecular and cellular plasticity in the nervous tissue and thus entails CNS dysfunction. The contribution of genetically determined features of the nervous system to the development of post-stress neuroinflammation has not been sufficiently studied. In this study, the dynamics of post-stress changes in mRNA levels of the il-1 β and tnf genes encoding proinflammatory cytokines interleukin-1 beta (IL-1β) and tumor necrosis factor (TNF) were evaluated in the blood and brain of two rat strains with high and low excitability thresholds of the nervous system (HT and LT, respectively). Changes in IL-1β and TNF mRNA levels were assessed by real-time PCR 24 h, 7, 24 and 60 days after long-term long-term emotional and painful stress in the blood and three brain structures involved in the development of post-stress pathology (prefrontal cortex, hippocampus, amygdala). In highly excitable LT rats, IL-1β mRNA level in the hippocampus and amygdala increased compared to the control 24 days after stress termination, while in low-excitable HT animals, an increase in the level of IL-1β mRNA was only detected in the hippocampus at the same time point. TNF mRNA level did not change in any of the rat strains at any of the post-stress time points. Genetically determined excitability of the nervous system is a promising marker of individual stress vulnerability, as manifested in post-stress disorders associated with developmental and time-course features of neuroinflammation.

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The Effect of Prolonged Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

Shalaginova,

Tuchina,

Turkin

et al. 2023

Rossijskij fiziologičeskij žurnal im. I.M. Sečenova

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Stress plays an important role in the pathogenesis of anxiety and depressive disorders. Neuroinflammation is considered as one of the mechanisms by which stress alters the molecular and cellular plasticity in the nervous tissue, which leads to a violation of the functions of the central nervous system. The contribution of genetically determined features of the nervous system to the development of post-stress neuroinflammation has not been sufficiently studied. In this study, the dynamics of poststress changes in the mRNA levels of the il1ß and tnf genes of proinflammatory cytokines interleukin-1-beta (IL-1ß) and tumor necrosis factor (TNF) in the blood and in the brain in two rat strains with high and low excitability thresholds of the nervous system (HT and LT) was evaluated. Changes in IL-1ß and TNF mRNA levels were assessed by real-time PCR 24 h, 7, 24 and 60 days after prolonged emotional and painful stress in the blood and three brain structures involved in the development of post-stress pathology (prefrontal cortex, hippocampus, amygdala). In highly excitable rats of the LT strain, the level of IL-1ß mRNA in the hippocampus and amygdala increased compared to the control 24 days after the end of stress, in low-excitable animals of the HT strain, an increase in the level of IL-1ß mRNA was detected only in the hippocampus at the same time. The TNF mRNA level did not change in any of the strains at any of the time points after stress. Genetically determined excitability of the nervous system is a promising marker of individual vulnerability to stress, manifested in post-stress disorders associated with the characteristics of the formation and dynamics of neuroinflammation.

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Spike Activity and Genome Instability in Neurons of the Amygdaloid Complex in Rats of Selected Strains with Contrasting Nervous System Arousability in Normal Conditions and Stress

Cited by 3 publications

References 24 publications

Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

Genome response of hippocampal cells to stress in male rats with different excitability of the nervous system

The Effect of Long-Term Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

The Effect of Prolonged Emotional and Painful Stress on the Expression of Proinflammatory Cytokine Genes in Rats with High and Low Excitability of the Nervous System

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